Abstract
Dopamine (3,4-dihydroxyphenethylamine) is a hormone and neurotransmitter of the catecholamine and phenethylamine families which plays a major role in reward-motivated behaviour. Dopaminergic neuromodulation is critical for many forms of memory. Dopaminergic D1/D5-receptor function is required for the induction of the protein synthesis-dependent maintenance of hippocampal late-LTP (L-LTP) through activation of the cAMP/PKA-pathway. This chapter will brief about dopaminergic neuromodulation required for the establishment of L-LTP and its late-associative processes such as synaptic tagging and capture (STC) in CA1 pyramidal neurons and how it varies in the different lamina of the same neurons. In addition we discuss how neuromodulation by dopamine leads to the synthesis of the major plasticity-related protein (PRP), protein kinase Mzeta (PKMĪ¶), and its role in maintaining STC at potentiated synapses.
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Navakkode, S. (2015). Dopaminergic Neuromodulation in Synaptic Tagging and Capture. In: Sajikumar, S. (eds) Synaptic Tagging and Capture. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1761-7_8
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DOI: https://doi.org/10.1007/978-1-4939-1761-7_8
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