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Physics of Photodynamic Therapy

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Biomedical Optics in Otorhinolaryngology

Abstract

Photodynamic therapy (PDT) uses light-activated drugs (photosensitizers) for the treatment of neoplastic and non-neoplastic diseases. Administration of the photosensitizer constitutes the first step in the PDT process. Then, following a waiting period (minutes to days) to allow for selective accumulation in the target tissue, the sensitizer is activated via light (usually from a laser) of a wavelength matching a prominent absorption resonance in the red or near-infrared part of the visible spectrum. Absorption of this light by the photosensitizer results in photochemical processes which ultimately produce the cytotoxic species (e.g., singlet molecular oxygen) responsible for the biological damage.

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  1. Department of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, 4505 South Maryland Pkwy., Box 453037, Las Vegas, NV, 89154, USA

    Steen J. Madsen Ph.D.

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  1. Department of Otolaryngology Head and Neck Surgery, Department of Biomedical Engineering, Division of Facial Plastic Surgery, The Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California, USA

    Brian J.-F. Wong

  2. Department of Otorhinolaryngology, Plastic, Head and Neck Surgery, RWTH Aachen University Hospital, Aachen, Germany

    Justus Ilgner

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Madsen, S.J. (2016). Physics of Photodynamic Therapy. In: Wong, BF., Ilgner, J. (eds) Biomedical Optics in Otorhinolaryngology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1758-7_18

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