Abstract
Gastroesophageal reflux disease (GERD) and its many manifestations are common in North America and Europe. Although less common in Asia, Middle East, Caribbean, and African countries, its prevalence is increasing in these regions as well. Although the incidence of new cases is relatively low, the disease persists over long periods of time, thereby leading to an overall high prevalence. Risk factors include age, gender, ethnicity, obesity, physiologic/anatomic conditions, and lifestyle. GERD is an economic burden to patients, healthcare systems, employers, and society. Barrett’s esophagus is one of the more serious consequences of GERD. Its primary importance is as a risk factor for esophageal adenocarcinoma. Although prevalence and incidence of Barretts is difficult to determine, it is probably more common than initially believed. Risk factors are similar to GERD, although diet may play an additional role.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Sobieraj DM, Coleman SM, Coleman CI. US prevalence of upper gastrointestinal symptoms: A systematic review. Am J Mang Care. 2011;17:e449–45.
Watson DI, Lally CJ. Prevalence of symptoms and use of medication for gastroesophageal reflux disease in an Australian community. World J Surg. 2009;33:88–94.
Fedorak RN, Veldhuyzen van Zanten S, Bridges R. Canadian Digestive Health Foundation Public Impact Series: gastroesophageal reflux disease in Canada: incidence, prevalence, and direct and indirect economic impact. Can J Gastroenterol. 2010;24:431–4.
Yuen E, Romney M, Toner RW, et al. Prevalence, knowledge and care patterns for gastro-oesophageal reflux disease in United States minority populations. Aliment Pharmacol Ther. 2010;32:645–54.
Gisbert JP, Cooper A, Karagiannis D, et al. Consultation rates and characteristics of gastro-oesophagel reflux disease in primary care: a European observational study. Eur J Gen Pract. 2009;15:154–60.
Fletcher KC, Goutte M, Slaughter JC, et al. Significance and degree of reflux in patients with primary extraesophageal symptoms. Laryngoscope. 2011;121:2561–5.
Ford AC, Suares NC, Talley NJ. Meta-analysis: the epidemiology of noncardiac chest pain in the community. Aliment Pharmacol Ther. 2011;34:172–80.
Jaspersen D, Kulig M, Labenz J, et al. Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD study. Aliment Pharmacol Ther. 2003;17:1515–20.
Fass R, Dickman R. Clinical consequences of silent gastroesophageal reflux disease. Curr Gastroenterol Rep. 2006;8:195–201.
Goh K-L, Shiaw-Hooi H. Silent gastroesophageal disease: clinical implications of an unknown disease. J Gastroenterol Hepatol. 2011;26:941–2.
Wang PC, Hsu CS, Tseng TC, et al. Male sex, hiatus hernia, and Helicobacter pylori infection associated with asymptomatic erosive esophagitis. J Gastroenterol Hepatol. 2012;27:586–91.
Ronkainen J, Talley NJ, Storskrubb T, et al. Erosive esophagitis is a risk factor for Barrett’s esophagus: a community-based endoscopic follow-up study. Am J Gastroenterol. 2011;106:1946–52.
Labenz J, Nocon M, Lind T, et al. Prospective follow-up data from the ProGERD study suggest that GERD is not a categorical disease. Am J Gastroenterol. 2006;101:2457–62.
Malfertheiner P, Nocon M, Vieth M, et al. Evolution of gastro-oesophageal reflux disease over 5 years under routine medical care—the ProGERD study. Aliment Pharmacol Ther. 2012; 35:154–64.
El-Serag H, Hill C, Jones R. Systematic review: the epidemiology of gastro-oesophageal reflux disease in primary care, using the UK General Practice Research Database. Aliment Pharmacol Ther. 2009;29:470–80.
Armstrong D. Systematic review: persistence and severity in gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2008;28:841–53.
Hansen JM, Wildner-Christensen M, Schaffalizky de Muckadell OB. Gastroesophageal reflux symptoms in a Danish population: a prospective follow-up analysis of symptoms, quality of life, and health-care use. Am J Gastroenterol. 2009;104:2394–403.
Ageing reference
Menon S, Trudgill N. Risk factors in the aetiology of hiatus hernia: a meta-analysis. Eur J Gastroenterol Hepatol. 2011;23:133–8.
Chen Z, Thompson SK, Jamieson GG, et al. Effect of sex on symptoms associated with gastroesophageal reflux. Arch Surg. 2011; 146:1164–9.
Kang JY. Systematic review: geographical and ethnic differences in gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2004;20:705–17.
Friedenberg FK, Rai J, Vanar V, et al. Prevalence and risk factors for gastroesophageal reflux disease in an impoverished minority population. Obes Res Clin Pract. 2010;4:e261–369.
Lagergren J. Influence of obesity on the risk of esophageal disorders. Nat Rev Gastroenterol Hepatol. 2011;8:340–7.
Sonnenberg A. Effects of environment and lifestyle on gastroesophageal reflux disease. Dig Dis. 2011;29:229–34.
Gao L, Weck MN, Rothenbacher D, Brenner H. Body mass index, chronic atrophic gastritis and heartburn: a population-based study among 8936 older adults from Germany. Aliment Pharmacol Ther. 2010;32:296–302.
Lofdahl HE, Lane A, Lu Y, et al. Increased population prevalence of reflux and obesity in the United Kingdom compare with Sweden: a potential explanation for the difference in incidence of esophageal adenocarcinoma. Eur J Gastroenterol Hepatol. 2011;23:128–32.
Savarino E, Zentilin P, Marabotto E, et al. Overweight is a risk factor for both erosive and non-erosive reflux disease. Dig Liver Dis. 2011;43:940–5.
Fujiwara Y, Kubo M, Kohata Y, et al. Cigarette smoking and its association with overlapping gastroesophageal reflux disease, functional dyspepsia or irritable bowel syndrome. Intern Med. 2011; 50:2443–7.
Gaddam S, Maddur H, Wani S, et al. Risk factors for nocturnal reflux in a large GERD cohort. J Clin Gastroenterol. 2011; 45:764–8.
Martin-Merino E, Ruigomez A, Garcia-Rodriguez LA, et al. Depression and treatment with antidepressants are associated with the development of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2010;31:1132–40.
Imagama S, Hasegawa Y, Wakao N, et al. Influence of lumbar kyphosis and back muscle strength on the symptoms of gastroesophageal reflux disease in middle-aged and elderly people. Eur Spine J. 2012; Feb 28 [Epub ahead of print]
Kim N, Lee SW, Baik GH, et al. Effect of Helicobacter pylori eradication on the development of reflux esophagitis and gastroesophageal reflux symptoms: a nationwide multi-center prospective study. Gut Liver. 2011;5:437–46.
Li J, Brackbill RM, Stellman SD, et al. Gastroesophageal reflux symptoms and comorbid asthma and posttraumatic stress disorder following the 9/11 terrorist attacks on World Trade Center in New York City. Am J Gastroenterol. 2011;106:1933–41.
Velanovich V. The effects of chronic pain syndromes and psycho-emotional disorders on symptomatic and quality of life outcomes of antireflux surgery. J Gastrointest Surg. 2003;7:53–8.
Wagner JS, DiBonaventura MD, Balu S, Buchner D. The burden of diurnal and nocturnal gastroesophageal reflux disease symptoms. Expert Rev Pharmacoecon Outcomes Res. 2011;11:739–49.
Gisbert JP, Cooper A, Karagiannis D, et al. Impact of gastroesophageal reflux disease on work absenteeism, presenteeism and productivity in daily life: a European observational study. Health Qual Life Outcomes. 2009;7:90.
Wahlqvist P, Karlsson M, Johnson D, et al. Relationship between symptom load of gastro-oesophageal reflux disease and health-related quality of life, work productivity, resource utilization and concomitant diseases: survey of a US cohort. Aliment Pharmacol Ther. 2008;27:960–70.
Toghanian S, Johnson DA, Stalhammar NO, Zerbib F. Burdent of gastro-oesophageal reflux disease in patients with persistent and intense symptoms despite proton pump inhibitor therapy: a post hoc analysis of the 2007 National Health and Wellness Survey. Clin Drug Investig. 2011;31:703–15.
Darba J, Kaskens L, Plans P, et al. Epidemiology and societal costs of gastroesophageal reflux disease and Barrett’s syndrome in Germany, Italy and Spain. Expert Rev Pharmacoecon Outcomes Res. 2011;11:225–32.
Gerson L, McLaughlin T, Balu S, et al. Variation of health-care resource utilization according to GERD-associated complications. Dis Esophagus 2012; Jan 31 [Epub ahead of print]
Jayadevappa R, Chhatre S, Weiner M. Gastro-oesophageal acid-related disease, co-morbidity and medical care cost. Chronic Illn. 2008;4:209–18.
Thukkani N, Sonnenberg A. The influence of environmental risk factors in hospitalization for gastro-oesophageal reflux disease-related diagnoses in the United States. Aliment Pharmacol Ther. 2010;31:852–61.
Gosselin A, Luo R, Lohouses H, et al. The impact of proton pump inhibitor compliance on health-care resource utilization and costs in patients with gastroesophageal reflux disease. Value Health. 2009;12:34–9.
Raman A, Sternbach J, Babajide A, et al. When does testing for GERD become cost effective in an integrated health network? Surg Endosc. 2010;24:1245–9.
Epstein D, Bojke L, Sculpher MJ, The REFLUX trial group. Laparoscopic fundoplication compared with medical management for gastro-oesophageal reflux disease: cost effectiveness study. BMJ. 2009;339:b2576.
Wang KK, Sampliner RE, Practice Parameters Committee of the American College of Gastroenterology. Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett’s esophagus. Am J Gastroenterol. 2008;103:788–97.
Spechler SJ. Clinical practice. Barrett’s esophagus. N Engl J Med. 2002;346:836–42.
Ronkainen J, Aro P, Storskrubb T, et al. Prevalence of Barrett’s esophagus in the general population: an endoscopic study. Gastroenterology. 2005;129:1825–31.
Westhoff B, Brotze S, Weston A, et al. The frequency of Barrett’s esophagus in high-risk patients with chronic GERD. Gastrointest Endosc. 2005;61:226–31.
Dickman R, Kim JL, Camargo L, et al. Correlation of gastroesophageal reflux disease symptom characteristics with long-segment Barrett’s esophagus. Dis Esophagus. 2006;19:360–5.
Cameron AJ. Epidemiology of Barrett’s esophagus and adenocarcinoma. Dis Esophagus. 2002;15:106–8.
Guardino JM, Khandwala F, Lopez R, et al. Barrett’s esophagus at a tertiary care center: association of age on incidence and prevalence of dysplasia and adenocarcinoma. Am J Gastroenterol. 2006;101:2187–93.
Cook MB, Shaheen NJ, Anderson LA, et al. Cigarette smoking increases risk of Barrett’s esophagus: An analysis of the Barrett’s and Esophageal Adenocarcinoma Consortium. Gastroenterology 2012; Jan 11 [Epub ahead of print]
Kubo A, Block G, Queensberry Jr CP, et al. Effects of dietary fiber, fats, and meat intakes on the risk of Barrett’s esophagus. Nutr Cancer. 2009;61:607–16.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer New York
About this chapter
Cite this chapter
Velanovich, V. (2015). Epidemiology and Socioeconomics of Reflux Disease. In: Swanstrom, L., Dunst, C. (eds) Antireflux Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1749-5_3
Download citation
DOI: https://doi.org/10.1007/978-1-4939-1749-5_3
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-1748-8
Online ISBN: 978-1-4939-1749-5
eBook Packages: MedicineMedicine (R0)