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Molecular Genetics of Dysregulated pH Homeostasis pp 123–133Cite as

Extracellular Acidosis and Cancer

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Abstract

Solid tumours acidify their interstitial fluid by a number of diverse processes that result in net proton export. These include activity of monocarbonate and bicarbonate transporters, V-type ATPases, carbonic anhydrases and voltage-gated proton channels. The acidic extracellular microenvironment influences the activity of cancer, vascular endothelial and immune cells such that tumour growth is promoted although the exact signalling pathways are still only poorly understood. This chapter addresses how changes in extracellular proton concentration can affect cells in cancerous tissue.

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Authors and Affiliations

  1. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, England

    Maike D. Glitsch

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  1. Maike D. Glitsch
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Correspondence to Maike D. Glitsch .

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Editors and Affiliations

  1. Department of Molecular Genetics and Microbiology, Duke Center for Genomic and Computational Biology, Durham, North Carolina, USA

    Jen-Tsan Ashley Chi

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Glitsch, M. (2014). Extracellular Acidosis and Cancer. In: Chi, JT. (eds) Molecular Genetics of Dysregulated pH Homeostasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1683-2_7

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