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The Role of Microbes in Common Non-Infectious Diseases pp 1–27Cite as

Irritable Bowel Syndrome and Microbial Pathogenesis

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Part of the book series: Emerging Infectious Diseases of the 21st Century ((EIDC,volume 1))

Abstract

Irritable bowel syndrome [IBS] is a common disturbance of the gastrointestinal tract of unknown cause, which is more prevalent in greater developed and affluent societies than poorer, developing regions of the world. Yet underdeveloped or developing countries have much greater incidence of infectious diarrheas, which is a strong risk factor for IBS in westernized societies. The prevalence of IBS in different countries, epidemiological association with sporadic or local outbreak of gastroenteritis, and traveler’s diarrhea are reviewed. Other risk factors and various hypotheses on the pathogenesis of IBS are discussed. Data on the emerging role of disturbances in the gut microbiota and microbiome from clinical studies and animal experimentation are analyzed and critiqued. Moreover, studies on the therapeutic benefit of new antimicrobials and probiotics are reviewed, and directions for future research and clinical trials to establish causality are suggested.

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  1. University of Toronto, Toronto, ON, Canada

    I. W. Fong

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Fong, I.W. (2014). Irritable Bowel Syndrome and Microbial Pathogenesis. In: The Role of Microbes in Common Non-Infectious Diseases. Emerging Infectious Diseases of the 21st Century, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1670-2_1

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