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Antibody-based Protection Against HIV Infection

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Humanized Mice for HIV Research

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Abstract

The hu-PBL-SCID mouse was among the first animal models to clearly demonstrate the ability of neutralizing antibodies to protect against the HIV challenge in vivo. Conclusions from these early experiments have largely been borne out in more recent studies performed with newer humanized mice models such as Rag-hu, NSG-hu, and BLT that show improved mimicry of human infections. In addition to passive transfer, protection has also been demonstrated for neutralizing antibodies delivered by viral vectors, i.e., vectored immunoprophylaxis. In addition, whereas early studies in hu-PBL-SCID mice showed antibodies to be relatively ineffective in control of established HIV infection because of neutralization escape, recent studies in newer models with cocktails of more potent neutralizing antibodies have shown effective control of virus replication and suppression of escape.

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Acknowledgments

We thank Christina Corbaci for help with graphic design. The authors acknowledge the financial support of the National Institute of Allergy and Infectious Diseases, the Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery; the International AIDS Vaccine Initiative; the Ragon Institute of MGH, MIT, and Harvard; and the Lundbeck Foundation.

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Authors and Affiliations

  1. Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, 92037, La Jolla, CA, USA

    Brian Moldt & Dennis R. Burton

  2. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, 02129, Boston, MA, USA

    Dennis R. Burton

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  1. Brian Moldt
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Correspondence to Brian Moldt .

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Editors and Affiliations

  1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA

    Larisa Y. Poluektova

  2. Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

    J. Victor Garcia

  3. Research Center for AIDS Laboratory of Viral Pathogenesis, Kyoto University Institute for Virus Research, Sakyo-ku, Japan

    Yoshio Koyanagi

  4. Division of Hematology, University Hospital Zürich, Zürich, Switzerland

    Markus G. Manz

  5. Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA

    Andrew M. Tager

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Moldt, B., Burton, D. (2014). Antibody-based Protection Against HIV Infection. In: Poluektova, L., Garcia, J., Koyanagi, Y., Manz, M., Tager, A. (eds) Humanized Mice for HIV Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1655-9_26

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