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Humanized Mouse Versus Non-human Primate Models of HIV-1 Infection

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Humanized Mice for HIV Research

Abstract

Animal models are critical for biomedical research including human immunodeficiency virus type one (HIV-1). Asian non-human primate (NHP) macaques and humanized mice (hu-mice) are the two best available models of HIV-1 infection of humans. Here, we compare and contrast the pros and cons of NHP and hu-mouse models of HIV-1 infection of humans in general; discuss in detail which model is more relevant in studying HIV-1 transmission and vaccine, and what aspects of these models need to be further improved in order to meet the HIV-1 research need.

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Authors and Affiliations

  1. Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, 4240 Fair Street, 68583-0900, Lincoln, NE, USA

    Qingsheng Li & Charles Wood

Authors
  1. Qingsheng Li
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  2. Charles Wood
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Correspondence to Qingsheng Li .

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA

    Larisa Y. Poluektova

  2. Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

    J. Victor Garcia

  3. Research Center for AIDS Laboratory of Viral Pathogenesis, Kyoto University Institute for Virus Research, Sakyo-ku, Japan

    Yoshio Koyanagi

  4. Division of Hematology, University Hospital Zürich, Zürich, Switzerland

    Markus G. Manz

  5. Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA

    Andrew M. Tager

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Li, Q., Wood, C. (2014). Humanized Mouse Versus Non-human Primate Models of HIV-1 Infection. In: Poluektova, L., Garcia, J., Koyanagi, Y., Manz, M., Tager, A. (eds) Humanized Mice for HIV Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1655-9_17

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