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Ancillary Immunohistochemical Techniques for the Subclassification of Non-small Cell Lung Cancer

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Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology

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Abstract

The majority of NSCLC falls in adenocarcinoma and squamous cell carcinoma, with the remainder including adenosquamous carcinoma, large cell carcinoma, sarcomatoid carcinoma, and salivary gland-type carcinoma. The importance of subclassifying NSCLC in biopsy and cytology material has been discussed in another chapter. While characteristic morphological features are usually evident in well-differentiated adenocarcinoma and squamous cell carcinoma, poorly differentiated carcinoma often requires immunohistochemistry. A number of antibodies are available, but none is absolutely specific for a particular histotype; therefore, a panel of immunohistochemistry markers is recommended. Currently recognized as reliable markers are TTF-1 and napsin A for adenocarcinoma, and p63, p40, and CK5/6 for squamous cell carcinoma. It should also be noted that the lung is the most common location for metastasis, and it is important to keep this possibility in mind.

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  1. Department of Histopathology, The Christie Hospital, Wilmslow Road, Manchester, M20 4BX, UK

    Daisuke Nonaka M.D.

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  1. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

    Andre Luis Moreira

  2. Department of Pathology and Cell Biology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, New York, USA

    Anjali Saqi

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Nonaka, D. (2015). Ancillary Immunohistochemical Techniques for the Subclassification of Non-small Cell Lung Cancer. In: Moreira, A., Saqi, A. (eds) Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1607-8_5

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