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The Role of Lymphadenectomy in the Management of Urothelial Carcinoma of the Upper Urinary Tract

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Upper Tract Urothelial Carcinoma

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Abstract

Lymphadenectomy is considered as an integral part of radical surgery for urologic malignancies. Many studies have been conducted to confirm its benefit in improving staging accuracy or survival, including in patients with renal cell carcinoma, prostate cancer, and urothelial carcinoma of the bladder. In renal cell carcinoma, the European Organization for Research and Treatment of Cancer (EORTC) randomized phase 3 Trial 30881 failed to show any therapeutic benefit of lymphadenectomy. However, this trial has been criticized for enrolling patient at a low risk of lymph node metastases. Other studies have supported the hypothesis that lymphadenectomy may be beneficial in patients with high-risk renal cell carcinoma.

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Acknowledgments

The authors thank Ms. Elizabeth Kiritani for the English correction of this manuscript. We also thank and Ms. Noriko Hata for secretarial work.

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Authors and Affiliations

  1. Department of Urology, Tokyo Women’s Medical University 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Tsunenori Kondo MD

  2. Urology Service, Memorial Sloan-Kettering Cancer Center, 353 E. 68th Street, New York, NY, 10065, USA

    Bernard H. Bochner MD, FACS

  3. Urologic Oncology, Institute of Urology, University of Southern California, Los Angeles, CA, USA

    Siamak Daneshmand MD

  4. Division of Urology, Department of Surgery and Division of Urology, Department of Surgical Oncology, Mount Sinai Hospital, Princess Margaret Cancer Centre/University Health Network and University of Toronto, Toronto, ON, Canada

    Alexandre R. Zlotta MD, PhD, FRCSC

Authors
  1. Tsunenori Kondo MD
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  2. Bernard H. Bochner MD, FACS
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  3. Siamak Daneshmand MD
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  4. Alexandre R. Zlotta MD, PhD, FRCSC
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Corresponding author

Correspondence to Alexandre R. Zlotta MD, PhD, FRCSC .

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Editors and Affiliations

  1. Department of Urology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria

    Shahrokh F. Shariat

  2. Department of Urology, Paris Descartes University, Paris, France

    Evanguelos Xylinas

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Kondo, T., Bochner, B.H., Daneshmand, S., Zlotta, A.R. (2015). The Role of Lymphadenectomy in the Management of Urothelial Carcinoma of the Upper Urinary Tract. In: Shariat, S., Xylinas, E. (eds) Upper Tract Urothelial Carcinoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1501-9_7

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