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Maternal Helminth Infections

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How Helminths Alter Immunity to Infection

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 828))

Abstract

Chronic helminth infections are highly prevalent in many parts of the world and a considerable infection rate during pregnancy has been reported. It is becoming clear that the development of the fetal immune system and the immune responses to homologous and possibly even heterologous antigens later in life is already determined in utero. The contributing factors and mechanisms are still under investigation. However, studies have demonstrated that maternal helminth infection can influence susceptibility to a homologous infection during childhood without previous fetomaternal transmission of the infectious agent itself during pregnancy. Whether this is caused e.g. by chronic maternal immune responses (cells or cytokines) such as immuneregulation or transmission of helminth derived antigen/proteins, and furthermore which developmental stage of the offspring’s immune system is affected by such factors e.g. in an epigenetic manner and finally, what clinical implications these results have regarding vaccination strategies, needs to be investigated in the future.

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Authors and Affiliations

  1. Department of Parasitology, Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, Trogerstrasse 30, 81675, Munich, Germany

    Kathrin Straubinger & Clarissa Prazeres da Costa

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  1. Kathrin Straubinger
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  2. Clarissa Prazeres da Costa
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Correspondence to Clarissa Prazeres da Costa .

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  1. Division of Immunology/IIDM, University of Cape Town, Cape Town, South Africa

    William Horsnell

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Straubinger, K., Prazeres da Costa, C. (2014). Maternal Helminth Infections. In: Horsnell, W. (eds) How Helminths Alter Immunity to Infection. Advances in Experimental Medicine and Biology, vol 828. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1489-0_2

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