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The Role of Antibody in Parasitic Helminth Infections

  • Erin Logan
  • Alisha Chetty
  • William G. HorsnellEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 828)

Abstract

A wealth of data on the protective immune mechanisms induced following helminth infection exist, but how antibody responses protect against helminth infections is unclear and shows variation between species. Understanding antibody responses to different helminth species is important to support the future development of anti-helminth vaccines that will be robust enough to protect against/inhibit infection (acute or chronic). Both the biological similarities and diversity of helminths highlights the importance of understanding both broad anti-helminth and species-specific host antibody responses. Vaccine development requires knowledge of which molecules would stimulate the most protective antibody responses, and whether certain molecules would be cross-reactive between species to be used for protection against multiple helminth species. Such information may lead to a reduced cost of vaccine development, encouraging effective implementation. The aim of this chapter is to assimilate our current understanding of antibody responses to helminths in mice, livestock and humans, and to discuss their importance in the context of potential vaccine development.

Keywords

Helminth infection Antibody IgG4 IgE Vaccine development 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Erin Logan
    • 2
  • Alisha Chetty
    • 3
  • William G. Horsnell
    • 1
    Email author
  1. 1.Division of Immunology/IIDMUniversity of Cape TownCape TownSouth Africa
  2. 2.Clinical and Laboratory Sciences, Division of Immunology, Health Sciences FacultyUniversity of Cape TownCape TownSouth Africa
  3. 3.Clinical Laboratory ScienceUniversity of Cape TownCape TownSouth Africa

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