Abstract
The accurate diagnosis of melanocytic neoplasms depends not only on adequate clinical sampling and careful histopathological evaluation, but also on technical variables that affect tissue preservation. Tissues must be examined and processed in a way that allows for diagnosis, margin assessment, and subsequent performance of additional immunohistochemical or molecular studies if necessary. This chapter reviews handling techniques for the most commonly encountered cutaneous melanocytic lesions.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Busam KJ. Molecular pathology of melanocytic tumors. Semin Diagn Pathol. 2013;30:362–74.
Gerami P, Li G, Pouryazdanparast P, et al. A highly specific and discriminatory FISH assay for distinguishing between benign and malignant melanocytic neoplasms. Am J Surg Pathol. 2012;36:808–17.
Jeck WR, Parker J, Carson CC, et al. Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma. Pigment Cell Melanoma Res. 2014;27(4):653–63.
North JP, Garrido MC, Kolaitis NA, Leboit PE, McCalmont TH, Bastian BC. Fluorescence in situ hybridization as an ancillary tool in the diagnosis of ambiguous melanocytic neoplasms: a review of 804 cases. Am J Surg Pathol. 2014;38(6):824–31.
Stevens G, Cockerell CJ. Avoiding sampling error in the biopsy of pigmented lesions. Arch Dermatol. 1996;132:1380–2.
Kerns MJ, Darst MA, Olsen TG, Fenster M, Hall P, Grevey S. Shrinkage of cutaneous specimens: formalin or other factors involved? J Cutan Pathol. 2008;35:1093–6.
Prieto VG, Argenyi ZB, Barnhill RL, et al. Are en face frozen sections accurate for diagnosing margin status in melanocytic lesions? Am J Clin Pathol. 2003;120: 203–8.
Trotter MJ. Melanoma margin assessment. Clin Lab Med. 2011;31:289–300.
NIH Consensus conference. Diagnosis and treatment of early melanoma. JAMA. 1992;268:1314–9.
Ivan D, Prieto VG. An update on reporting histopathologic prognostic factors in melanoma. Arch Pathol Lab Med. 2011;135:825–9.
Kmetz EC, Sanders H, Fisher G, Lang PG, Maize JCS. The role of observation in the management of atypical nevi. South Med J. 2009;102:45–8.
Kolman O, Hoang MP, Piris A, Mihm MCJ, Duncan LM. Histologic processing and reporting of cutaneous pigmented lesions: recommendations based on a survey of 94 dermatopathologists. J Am Acad Dermatol. 2010;63:661–7.
Kunishige JH, Brodland DG, Zitelli JA. Surgical margins for melanoma in situ. J Am Acad Dermatol. 2012;66:438–44.
Scolyer RA, Judge MJ, Evans A, et al. Data set for pathology reporting of cutaneous invasive melanoma: recommendations from the international collaboration on cancer reporting (ICCR). Am J Surg Pathol. 2013;37:1797–814.
Sellheyer K, Bergfeld WF, Stewart E, Roberson G, Hammel J. Evaluation of surgical margins in melanocytic lesions: a survey among 152 dermatopathologists. J Cutan Pathol. 2005;32:293–9.
Shors AR, Kim S, White E, et al. Dysplastic naevi with moderate to severe histological dysplasia: a risk factor for melanoma. Br J Dermatol. 2006;155:988–93.
Tallon B, Snow J. Low clinically significant rate of recurrence in benign nevi. Am J Dermatopathol. 2012;34:706–9.
Weinstein MC, Brodell RT, Bordeaux J, Honda K. The art and science of surgical margins for the dermatopathologist. Am J Dermatopathol. 2012;34:737–45.
Reddy KK, Farber MJ, Bhawan J, Geronemus RG, Rogers GS. Atypical (dysplastic) nevi: outcomes of surgical excision and association with melanoma. JAMA Dermatol. 2013;149:928–34.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
Reed, J.A., Prieto, V.G., Shea, C.R. (2015). Gross Prosection of Melanocytic Lesions. In: Shea, C., Reed, J., Prieto, V. (eds) Pathology of Challenging Melanocytic Neoplasms. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1444-9_1
Download citation
DOI: https://doi.org/10.1007/978-1-4939-1444-9_1
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-1443-2
Online ISBN: 978-1-4939-1444-9
eBook Packages: MedicineMedicine (R0)