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Extrasynaptic GABAA Receptors pp 1–14Cite as

Extrasynaptic GABAA Receptors

A Brief Introduction to Extrasynaptic GABAA Receptors and ‘Tonic’ GABAA Receptor-Mediated Inhibition in Physiology and Disease

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Part of the book series: The Receptors ((REC,volume 27))

Abstract

γ-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain and its actions are mediated by two diverse families of neurotransmitter receptors, the ionotropic receptors, known as GABAA receptors, and metabotropic receptors that are classified as GABAB receptors. The classical phasic inhibitory postsynaptic potential (IPSP) is mediated by GABAA receptors that are located in the postsynaptic membrane. However, GABA also produces tonic inhibition through activation of GABAA receptors that are located outside the synapse. These extrasynaptic GABAA receptors respond to low concentrations of GABA to provide more spatially and temporally diffuse inhibition compared to their synaptic counterparts. This book covers the most current knowledge of extrasynaptic GABAA receptor structure, function, cellular distribution and pharmacology and the roles of tonic inhibition in neuronal excitability, physiology and pathophysiology.

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  1. Neuroscience and Mental Health Research Institute, Institute of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, United Kingdom

    Adam C. Errington

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  1. Adam C. Errington
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Correspondence to Adam C. Errington .

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  1. Neuroscience and Mental Health Research Institute, Institute of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, United Kingdom

    Adam C. Errington

  2. Dept. of Physiology & Biochemistry, University of Malta, Msida MSD, Malta

    Giuseppe Di Giovanni

  3. School of Biosciences, Cardiff University, Cardiff, United Kingdom

    Vincenzo Crunelli

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Errington, A. (2014). Extrasynaptic GABAA Receptors. In: Errington, A., Di Giovanni, G., Crunelli, V. (eds) Extrasynaptic GABAA Receptors. The Receptors, vol 27. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1426-5_1

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