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Nonmelanoma Skin Cancers

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Surgical Oncology

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Abstract

Nonmelanoma skin cancers are a group of heterogeneous cutaneous tumors that range from some of the most common human malignancies to extremely rare variants. Surgery remains the primary modality for treating these skin cancers, and the initial evaluation and diagnostic biopsy dictate subsequent treatment. Nonsurgical treatments are evolving and have been applied with mixed success. The identification of specific genetic mutations and critical cellular signaling pathways has generated excitement for novel targeting agents that have shown clinical efficacy.

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Abbreviations

5-FU:

5-fluorouracil

AJCC:

American Joint Committee on Cancer

AK:

Actinic keratosis

AS:

Angiosarcoma

BCC:

Basal cell carcinoma

CCI:

Crude cumulative incidence

CK-20:

Cytokeratin 20

CLL:

Chronic lymphocytic leukemia

DFSP:

Dermatofibrosarcoma protuberans

ED&C:

Electrodesiccation and curettage

EMPD:

Extramammary Paget’s disease

EPC:

Eccrine porocarcinoma

MCC:

Merkel cell carcinoma

MCV:

Merkel cell polyomavirus

MPD:

Mammary Paget’s disease

NCCN:

National Comprehensive Cancer Network

NMSC:

Nonmelanoma skin cancer

PDT:

Photodynamic therapy

PTCH1:

Patched 1 gene

RT:

Radiation therapy

SCC:

Squamous cell carcinoma

SEER:

Surveillance epidemiology and end results

SLNB:

Sentinel lymph node biopsy

TTF-1:

Thyroid transcription factor 1

UV:

Ultraviolet light

References

  1. Kasper M, Jaks V, Hohl D, Toftgard R. Basal cell carcinoma – molecular biology and potential new therapies. J Clin Invest. 2012;122(2):455–63. Epub 2012/02/02.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  2. Hogan DJ, To T, Gran L, Wong D, Lane PR. Risk factors for basal cell carcinoma. Int J Dermatol. 1989;28(9):591–4. Epub 1989/11/01.

    Article  PubMed  CAS  Google Scholar 

  3. Roewert-Huber J, Lange-Asschenfeldt B, Stockfleth E, Kerl H. Epidemiology and aetiology of basal cell carcinoma. Br J Dermatol. 2007;157 Suppl 2:47–51. Epub 2007/12/11.

    Article  PubMed  CAS  Google Scholar 

  4. de Zwaan SE, Haass NK. Genetics of basal cell carcinoma. Australas J Dermatol. 2010;51(2):81–92; quiz 3–4; Epub 2010/06/16.

    Article  PubMed  Google Scholar 

  5. Dourmishev LA, Rusinova D, Botev I. Clinical variants, stages, and management of basal cell carcinoma. Indian Dermatol Online J. 2013;4(1):12–7. Epub 2013/02/27.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Saldanha G, Fletcher A, Slater DN. Basal cell carcinoma: a dermatopathological and molecular biological update. Br J Dermatol. 2003;148(2):195–202. Epub 2003/02/18.

    Article  PubMed  CAS  Google Scholar 

  7. Edge SB, Byrd DR, Compton CC, et al. Cutaneous squamous cell carcinoma and other cutaneous carcinomas. In: AJCC cancer staging manual. 7th ed. New York: Springer; 2010. p. 523–6.

    Google Scholar 

  8. Gulleth Y, Goldberg N, Silverman RP, Gastman BR. What is the best surgical margin for a Basal cell carcinoma: a meta-analysis of the literature. Plast Reconstr Surg. 2010;126(4):1222–31. Epub 2010/10/05.

    Article  PubMed  CAS  Google Scholar 

  9. Avril MF, Auperin A, Margulis A, Gerbaulet A, Duvillard P, Benhamou E, et al. Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study. Br J Cancer. 1997;76(1):100–6. Epub 1997/01/01.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  10. Stockfleth E. The paradigm shift in treating actinic keratosis: a comprehensive strategy. J Drugs Dermatol: JDD. 2012;11(12):1462–7. Epub 2013/02/05.

    PubMed  CAS  Google Scholar 

  11. Rowe DE, Carroll RJ, Day Jr CL. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol. 1992;26(6):976–90. Epub 1992/06/11.

    Article  PubMed  CAS  Google Scholar 

  12. Brodland DG, Zitelli JA. Surgical margins for excision of primary cutaneous squamous cell carcinoma. J Am Acad Dermatol. 1992;27(2 Pt 1):241–8. Epub 1992/08/01.

    Article  PubMed  CAS  Google Scholar 

  13. Samarasinghe V, Madan V. Nonmelanoma skin cancer. J Cutan Aesthet Surg. 2012;5(1):3–10. Epub 2012/05/05.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Kwon S, Dong ZM, Wu PC. Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma: clinical experience and review of literature. World J Surg Oncol. 2011;9:80. Epub 2011/07/21.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Veness MJ. High-risk cutaneous squamous cell carcinoma of the head and neck. J Biomed Biotechnol. 2007;2007(3):80572. Epub 2007/06/02.

    PubMed  PubMed Central  Google Scholar 

  16. Fink-Puches R, Soyer HP, Hofer A, Kerl H, Wolf P. Long-term follow-up and histological changes of superficial nonmelanoma skin cancers treated with topical delta-aminolevulinic acid photodynamic therapy. Arch Dermatol. 1998;134(7):821–6. Epub 1998/07/29.

    Article  PubMed  CAS  Google Scholar 

  17. Marmur ES, Schmults CD, Goldberg DJ. A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer. Dermatol Surg. 2004;30(2 Pt 2):264–71. Epub 2004/02/12.

    PubMed  Google Scholar 

  18. Morton C, Horn M, Leman J, Tack B, Bedane C, Tjioe M, et al. Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or fluorouracil for treatment of squamous cell carcinoma in situ: results of a multicenter randomized trial. Arch Dermatol. 2006;142(6):729–35. Epub 2006/06/21.

    Article  PubMed  CAS  Google Scholar 

  19. Patel GK, Goodwin R, Chawla M, Laidler P, Price PE, Finlay AY, et al. Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen’s disease): a randomized, double-blind, placebo-controlled trial. J Am Acad Dermatol. 2006;54(6):1025–32. Epub 2006/05/23.

    Article  PubMed  Google Scholar 

  20. Uribe P, Gonzalez S. Epidermal growth factor receptor (EGFR) and squamous cell carcinoma of the skin: molecular bases for EGFR-targeted therapy. Pathol Res Pract. 2011;207(6):337–42. Epub 2011/05/03.

    Article  PubMed  CAS  Google Scholar 

  21. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567–78. Epub 2006/02/10.

    Article  PubMed  CAS  Google Scholar 

  22. Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Penas PF, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol. 2008;58(3):375–81. Epub 2008/02/19.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Agelli M, Clegg LX. Epidemiology of primary Merkel cell carcinoma in the United States. J Am Acad Dermatol. 2003;49(5):832–41. Epub 2003/10/25.

    Article  PubMed  Google Scholar 

  24. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319(5866):1096–100. Epub 2008/01/19.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  25. Scott MP, Helm KF. Cytokeratin 20: a marker for diagnosing Merkel cell carcinoma. Am J Dermatopathol. 1999;21(1):16–20. Epub 1999/02/23.

    Article  PubMed  CAS  Google Scholar 

  26. Allen PJ, Bowne WB, Jaques DP, Brennan MF, Busam K, Coit DG. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clin Oncol. 2005;23(10):2300–9. Epub 2005/04/01.

    Article  PubMed  Google Scholar 

  27. Medina-Franco H, Urist MM, Fiveash J, Heslin MJ, Bland KI, Beenken SW. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol. 2001;8(3):204–8. Epub 2001/04/21.

    Article  PubMed  CAS  Google Scholar 

  28. Mojica P, Smith D, Ellenhorn JD. Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin. Journal Clin Oncol. 2007;25(9):1043–7. Epub 2007/03/21.

    Article  Google Scholar 

  29. Poulsen M, Rischin D, Walpole E, Harvey J, Mackintosh J, Ainslie J, et al. High-risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: a Trans-Tasman Radiation Oncology Group Study–TROG 96:07. J Clin Oncol. 2003;21(23):4371–6. Epub 2003/12/04.

    Article  PubMed  CAS  Google Scholar 

  30. Sanmartin O, Llombart B, Lopez-Guerrero JA, Serra C, Requena C, Guillen C. Dermatofibrosarcoma protuberans. Actas dermo-sifiliograficas. 2007;98(2):77–87. Epub 2007/04/03.

    Article  PubMed  CAS  Google Scholar 

  31. Llombart B, Serra-Guillen C, Monteagudo C, Lopez Guerrero JA, Sanmartin O. Dermatofibrosarcoma protuberans: a comprehensive review and update on diagnosis and management. Semin Diagn Pathol. 2013;30(1):13–28. Epub 2013/01/19.

    Article  PubMed  Google Scholar 

  32. Gloster Jr HM. Dermatofibrosarcoma protuberans. J Am Acad Dermatol. 1996;35(3 Pt 1):355–74; quiz 75–6; Epub 1996/09/01.

    Article  PubMed  Google Scholar 

  33. Malhotra B, Schuetze SM. Dermatofibrosarcoma protuberans treatment with platelet-derived growth factor receptor inhibitor: a review of clinical trial results. Curr Opin Oncol. 2012;24(4):419–24. Epub 2012/04/19.

    Article  PubMed  CAS  Google Scholar 

  34. Monroe AT, Feigenberg SJ, Mendenhall NP. Angiosarcoma after breast-conserving therapy. Cancer. 2003;97(8):1832–40. Epub 2003/04/04.

    Article  PubMed  Google Scholar 

  35. Stewart FW, Treves N. Lymphangiosarcoma in postmastectomy lymphedema; a report of six cases in elephantiasis chirurgica. Cancer. 1948;1(1):64–81. Epub 1948/05/01.

    Article  PubMed  CAS  Google Scholar 

  36. Breiteneder-Geleff S, Soleiman A, Kowalski H, Horvat R, Amann G, Kriehuber E, et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol. 1999;154(2):385–94. Epub 1999/02/23.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  37. DeMartelaere SL, Roberts D, Burgess MA, Morrison WH, Pisters PW, Sturgis EM, et al. Neoadjuvant chemotherapy-specific and overall treatment outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement. Head Neck. 2008;30(5):639–46. Epub 2008/01/24.

    Article  PubMed  Google Scholar 

  38. Lloyd J, Flanagan AM. Mammary and extramammary Paget’s disease. J Clin Pathol. 2000;53(10):742–9. Epub 2000/11/07.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  39. Goldblum JR, Hart WR. Perianal Paget’s disease: a histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma. Am J Surg Pathol. 1998;22(2):170–9. Epub 1998/03/21.

    Article  PubMed  CAS  Google Scholar 

  40. Murata Y, Kumano K. Extramammary Paget’s disease of the genitalia with clinically clear margins can be adequately resected with 1 cm margin. Eur J Dermatol: EJD. 2005;15(3):168–70. Epub 2005/05/24.

    PubMed  CAS  Google Scholar 

  41. Moretto P, Nair VJ, Hallani SE, Malone S, Belanger E, Morash C, et al. Management of penoscrotal extramammary Paget disease: case series and review of the literature. Curr Oncol. 2013;20(4):e311–20. Epub 2013/08/02.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  42. Plaza JA, Torres-Cabala C, Ivan D, Prieto VG. HER-2/neu expression in extramammary Paget disease: a clinicopathologic and immunohistochemistry study of 47 cases with and without underlying malignancy. J Cutan Pathol. 2009;36(7):729–33. Epub 2009/06/13.

    Article  PubMed  Google Scholar 

  43. Penneys NS, Ackerman AB, Indgin SN, Mandy SH. Eccrine poroma: two unusual variants. Br J Dermatol. 1970;82(6):613–5. Epub 1970/06/01.

    Article  PubMed  CAS  Google Scholar 

  44. Robson A, Greene J, Ansari N, Kim B, Seed PT, McKee PH, et al. Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol. 2001;25(6):710–20. Epub 2001/06/08.

    Article  PubMed  CAS  Google Scholar 

  45. Lozano Orella JA, Valcayo Penalba A, San Juan CC, Vives Nadal R, Castro Morrondo J, Tunon AT. Eccrine porocarcinoma. Report of nine cases. Dermatol Surg. 1997;23(10):925–8.

    Article  PubMed  CAS  Google Scholar 

  46. Compton C, Byrd D, Garcia-Aguilar J, et al. Cutaneous squamous cell carcinoma and other cutaneous carcinomas. In: Compton C, Byrd D, Garcia-Aguilar J, Kurtzman S, Olawaiye A, Washington M, editors. AJCC cancer staging atlas. 2nd ed. New York: Springer; 2012. p. 357–70.

    Chapter  Google Scholar 

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Author information

Authors and Affiliations

  1. Surgical Oncology, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY, 14263, USA

    Moshim Kukar M.D., Jacqueline Oxenberg D.O. & Joseph Skitzki M.D.

  2. Department of Surgery, Kaleida Health/Buffalo General Med Center, State University of New York at Buffalo, 100 High St., Buffalo, 14203, NY, USA

    Edward Eun Cho M.D., Sc.M.

  3. Dermatology, University of Arizona, 1515 N Campbell Avenue #1907, 245024, Tucson, AZ, 85724, USA

    Nathalie C. Zeitouni M.D.C.M.

Authors
  1. Moshim Kukar M.D.
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  2. Jacqueline Oxenberg D.O.
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  3. Edward Eun Cho M.D., Sc.M.
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  4. Nathalie C. Zeitouni M.D.C.M.
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  5. Joseph Skitzki M.D.
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Corresponding author

Correspondence to Joseph Skitzki M.D. .

Editor information

Editors and Affiliations

  1. Department of Surgery, LSU Health Sciences Center-Shreveport, Shreveport, Louisiana, USA

    Quyen D. Chu

  2. Department of Surgery, Jersey Shore University Medical Center, Neptune, New Jersey, USA

    John F. Gibbs

  3. John C. McDonald Regional Transplant Center, Willis Knighton Health System, Shreveport, Louisiana, USA

    Gazi B. Zibari

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Kukar, M., Oxenberg, J., Cho, E.E., Zeitouni, N.C., Skitzki, J. (2015). Nonmelanoma Skin Cancers. In: Chu, Q., Gibbs, J., Zibari, G. (eds) Surgical Oncology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1423-4_2

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  • DOI: https://doi.org/10.1007/978-1-4939-1423-4_2

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