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Subunit Vaccine Delivery pp 347–369Cite as

Transcutaneous Immunization

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Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Transcutaneous immunization (TCI) is a relatively new and promising minimally invasive technique for vaccination. It involves topical delivery of vaccines to immune cells residing in the skin. The skin is the largest immune organ (total surface area of 1.8 m2) and contains a diverse array of immune cells including Langerhans cells (LCs) and dermal dendritic cells (DDCs). This creates the potential for TCI to be an excellent alternative to traditional vaccination methods. Due to the promise of this approach numerous preclinical animal studies and limited human studies have been carried out utilizing TCI (some of which will be summarized in this review) and it is surely only a matter of time until such products reach the market.

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Authors and Affiliations

  1. School of Pharmacy, University of Otago, 56, Dunedin, 9054, New Zealand

    Teerawan Rattanapak & Sarah Hook

  2. Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark

    Camilla Foged

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  1. Teerawan Rattanapak
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  2. Camilla Foged
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  3. Sarah Hook
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Correspondence to Sarah Hook .

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  1. Department of Pharmacy, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark

    Camilla Foged

  2. University of Copenhagen, Copenhagen, Denmark

    Thomas Rades

  3. Pharmacy School, Aston University, School of Life and Health Sciences, Birmingham, United Kingdom

    Yvonne Perrie

  4. Division of Health Sciences, University of Otago, School of Pharmacy, Dunedin, New Zealand

    Sarah Hook

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Rattanapak, T., Foged, C., Hook, S. (2015). Transcutaneous Immunization. In: Foged, C., Rades, T., Perrie, Y., Hook, S. (eds) Subunit Vaccine Delivery. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1417-3_18

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