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Implants as Sustained Release Delivery Devices for Vaccine Antigens

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Subunit Vaccine Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

The focus of this chapter will be on implantable devices for the purpose of vaccine delivery. This area of research has not yet been fully explored, but the most recent literature will be summarized. The chapter will provide some background and historical information on implants. In addition, different ways of manufacturing implants, from small lab-scale to potential large-scale production, will be described. Characterization of the implants will be discussed, with a focus on antigen release as well as degradation/erosion processes. Preclinical studies for assessment of biocompatibility, bioerosion, and in vivo release will be discussed. Finally, an outlook will be given for potential application fields in the future.

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Authors and Affiliations

  1. Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, 81377, Munich, Germany

    Julia Engert

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  1. Julia Engert
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Correspondence to Julia Engert .

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Editors and Affiliations

  1. Department of Pharmacy, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark

    Camilla Foged

  2. University of Copenhagen, Copenhagen, Denmark

    Thomas Rades

  3. Pharmacy School, Aston University, School of Life and Health Sciences, Birmingham, United Kingdom

    Yvonne Perrie

  4. Division of Health Sciences, University of Otago, School of Pharmacy, Dunedin, New Zealand

    Sarah Hook

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Engert, J. (2015). Implants as Sustained Release Delivery Devices for Vaccine Antigens. In: Foged, C., Rades, T., Perrie, Y., Hook, S. (eds) Subunit Vaccine Delivery. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1417-3_12

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