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Targeted Therapy of Acute Myeloid Leukemia pp 559–572Cite as

New Heterogeneity of the Leukemic Stem Cells

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Part of the book series: Current Cancer Research ((CUCR))

Abstract

The cancer stem cell (CSC) hypothesis proposes that cancer is propagated by a subpopulation of cells with stem cell properties, namely the ability to proliferate while balancing self-renewal with differentiation, to maintain the cancer. The presence of CSCs provides an explanation for the biological heterogeneity of cells within a cancer. In this chapter, we will focus mostly on acute myeloid leukemia, which was the first described model of CSCs. We will summarize recent data demonstrating a novel complexity of the leukemic stem cells compartment and discuss the potential implications this might have on targeting these cells.

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Author information

Authors and Affiliations

  1. Haematopoietic Stem Cell Laboratory Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, WC2A 3PX, London, UK

    Dominique Bonnet Ph.D.

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  1. Dominique Bonnet Ph.D.
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Correspondence to Dominique Bonnet Ph.D. .

Editor information

Editors and Affiliations

  1. Dept. Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Michael Andreeff

Conclusions

Conclusions

The CSC field has evolved rapidly over the past 2 decades, however it is becoming clear that the CSC or LSC is not a single entity, and more work is required to identify the LSC (or indeed LSCs) in a given patient. It is likely that a functional definition of the LSC will be required, in addition to a combination of surface markers and a characteristic gene expression program, in order to encompass the diversity of LSCs both within and between patients. This heterogeneity poses challenges in developing an effective LSC-directed therapeutic approach.

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Bonnet, D. (2015). New Heterogeneity of the Leukemic Stem Cells. In: Andreeff, M. (eds) Targeted Therapy of Acute Myeloid Leukemia. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1393-0_28

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  • DOI: https://doi.org/10.1007/978-1-4939-1393-0_28

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1392-3

  • Online ISBN: 978-1-4939-1393-0

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