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Targeted Therapy of Acute Myeloid Leukemia pp 509–528Cite as

NR4A Orphan Receptors as Drug Targets

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Part of the book series: Current Cancer Research ((CUCR))

Abstract

The orphan receptor NR4Al (Nur77, TR3, NGFI-B) is overexpressed in many different cancer cell lines and tumors, and, in leukemia cells, NR4Al is also more highly expressed than in B- or T-cell. In contrast, we observed the opposite pattern of NR4A2 (Nurrl) expression in these same cells. NR4Al is primarily oncogenic in cancer cell lines and is a target for inhibitors or inactivators and treatment of Jurkat cells with an NR4Al inactivator-induced apoptosis and inhibited cell growth. The in vitro characterization of NR4Al as pro-oncogenic in leukemia cells is in contrast to the tumor suppressor-like activity of NR4Al in transgenic mouse models, and these differences are currently being investigated.

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Acknowledgment

The support of Texas AgriLife and the National Institutes of Health (CA124998) is gratefully appreciated.

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Authors and Affiliations

  1. Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, 77843, College Station, TX, USA

    Stephen Safe

  2. Institute of Biosciences and Technology, Texas A&M Health Science Center, 2121 W. Holcombe Blvd, 77030, Houston, TX, USA

    Stephen Safe & Syng-Ook Lee

  3. Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, 77843, College Station, TX, USA

    Cong Meng & Beiyan Zhou

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  1. Stephen Safe
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  2. Syng-Ook Lee
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  3. Cong Meng
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  4. Beiyan Zhou
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Correspondence to Stephen Safe .

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Editors and Affiliations

  1. Dept. Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Michael Andreeff

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Safe, S., Lee, SO., Meng, C., Zhou, B. (2015). NR4A Orphan Receptors as Drug Targets. In: Andreeff, M. (eds) Targeted Therapy of Acute Myeloid Leukemia. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1393-0_26

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