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The Use of “Omics” to Guide the Selection of Targeted Therapy

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Targeted Therapy of Acute Myeloid Leukemia

Part of the book series: Current Cancer Research ((CUCR))

Abstract

In this book, the role of many different proteins, pathways, or genetic events in affecting the function of leukemic cells, as well as their suitability for therapeutic modulation, is discussed. However, since acute myeloid leukemia (AML) is a very heterogeneous disease, it will be necessary to match the characteristics of individual patients to the selection of the right targeted agent in order to maximize efficacy. In this chapter, we discuss how the application of the numerous molecular profiling arrays that are now available can be utilized to provide the answer to this dilemma. The development of methods to combine data from multiple arrays, termed “integromics” will enable a more sophisticated application of “omic” data that will facilitate the selection of combinations of targeted agents on an individualized basis.

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Acknowledgments

Thanks to Dr. Richard Eric Davis for critical reading and suggestions.

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Authors and Affiliations

  1. Department of Leukemia and Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Box 448, Houston, TX 77030, USA

    Steven M. Kornblau M.D.

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  1. Steven M. Kornblau M.D.
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Correspondence to Steven M. Kornblau M.D. .

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Editors and Affiliations

  1. Dept. Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Michael Andreeff

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Kornblau, S. (2015). The Use of “Omics” to Guide the Selection of Targeted Therapy. In: Andreeff, M. (eds) Targeted Therapy of Acute Myeloid Leukemia. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1393-0_2

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  • DOI: https://doi.org/10.1007/978-1-4939-1393-0_2

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