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Perinatal Programming of Neurodevelopment pp 75–100Cite as

Prenatal Stress and Adult Drug-Seeking Behavior: Interactions with Genes and Relation to Nondrug-Related Behavior

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Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 10))

Abstract

Addiction inflicts large personal, social, and economic burdens, yet its etiology is poorly defined and effective treatments are lacking. As with other neuropsychiatric disorders, addiction is characterized by a core set of symptoms and behaviors that are believed to be influenced by complex gene–environment interactions. Our group focuses on the interaction between early stress and genetic background in determining addiction vulnerability. Prior work by our group and others has indicated that a history of prenatal stress (PNS) in rodents elevates adult drug seeking in a number of behavioral paradigms. The focus of the present chapter is to summarize work in the area of PNS and addiction models as well as our recent studies of PNS on drug seeking in different strains of mice as a strategy to dissect gene–environment interactions underlying cocaine addiction vulnerability. These studies indicate that ability of PNS to elevate adult cocaine seeking is strain dependent. Further, PNS also alters other nondrug behaviors in a fashion that is dependent on different strains and independent from the strain dependence of drug seeking. Thus, it appears that the ability of PNS to alter behavior related to different psychiatric conditions is orthogonal, with similar nonspecific susceptibility to prenatal stress across genetic backgrounds but with the genetic background determining the specific nature of the PNS effects. Finally, the advent of recombinant inbred mouse strains is allowing us to determine the genetic bases of these gene–environment interactions. Understanding these effects will have broad implications to determining the nature of vulnerability to addiction and perhaps other disorders.

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Acknowledgments

This work was supported by National Institute on Drug Abuse (NIDA) grant DA-027525 and a National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award to TEK.

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The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Psychological and Brain Sciences, University of California, 93106-9660, Santa Barbara, CA, USA

    Tod E. Kippin, Jaonnalee C. Campbell, Kyle Ploense, Chris P. Knight & Jared Bagley

  2. Neuroscience Research Institute, University of California, 93106-9660, Santa Barbara, CA, USA

    Tod E. Kippin

  3. The Institute for Collaborative Biotechnology, University of California, 93106-9660, Santa Barbara, CA, USA

    Tod E. Kippin

  4. Center for Neuropharmacology and Neuroscience, Albany Medical College, MC-136, 47 New Scotland Avenue, 12208, Albany, NY, USA

    Jaonnalee C. Campbell

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  1. Tod E. Kippin
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  2. Jaonnalee C. Campbell
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Correspondence to Tod E. Kippin .

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  1. Facultad de Medicina Inst de Biologia Celular y Neurociecias, Universidad de Buenos Aires, Buenos Aires, Argentina

    Marta C. Antonelli

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Kippin, T., Campbell, J., Ploense, K., Knight, C., Bagley, J. (2015). Prenatal Stress and Adult Drug-Seeking Behavior: Interactions with Genes and Relation to Nondrug-Related Behavior. In: Antonelli, M. (eds) Perinatal Programming of Neurodevelopment. Advances in Neurobiology, vol 10. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1372-5_5

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