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Borderline Personality Disorder and Mood Disorders: Longitudinal Course and Interactions

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Borderline Personality and Mood Disorders

Abstract

Borderline personality disorder (BPD) is often misdiagnosed as a mood disorder, especially bipolar disorder. Mood disorder diagnostic variants that broaden the definitions of disorders often lead in clinical practice to the inappropriate use of medications, to a proliferation of medication changes, and sometimes to extensive and harmful polypharmacy aimed at addressing clinical problems that may well be the result of BPD, occurring either alone or as a comorbid condition. Examining the longitudinal course of BPD and comorbid mood disorders and their interactions over time may shed light not only on the disorder of primary importance but also, as a result, on the need to recognize and treat BPD with psychotherapy in order to achieve optimal outcomes in such cases. Results of four large-scale studies of the naturalistic, interactive course of personality disorders and mood disorders are reviewed in this chapter. The results indicate a strong interaction between BPD and major depressive disorder (MDD), suggesting overlapping psychopathologies and etiologies and weaker evidence for relationships between BPD and bipolar disorder. Research and clinical implications of these findings are discussed.

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References

  1. Ruggero CJ, Zimmerman M, Chelminski I, Young D. Borderline personality disorder and the misdiagnosis of bipolar disorder. J Psychiatr Res. 2010;44:405–8.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Zimmerman M, Ruggero CJ, Chelminski I, Young D. Psychiatric diagnoses in patients previously diagnosed with bipolar disorder. J Clin Psychiatry. 2010;71:26–31.

    Article  PubMed  Google Scholar 

  3. Benazzi F. Bipolar II, disorder: epidemiology, diagnosis, and management. CNS Drugs. 2007;21:727–40.

    Article  PubMed  CAS  Google Scholar 

  4. Akiskal HS, Bourgeois ML, Angst J, Post R, Moller H, Hirschfield R. Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. J Affect Disord. 2000;59 Suppl 1:S5–30.

    Article  PubMed  Google Scholar 

  5. Akiskal HS, Pinto O. The evolving bipolar spectrum: prototypes I, II, III, and IV. Psychiatr Clin North Am. 1999;22:517–34.

    Article  PubMed  CAS  Google Scholar 

  6. Judd LL, Akiskal HS, Maser JD, Zeller PJ, Endicott J, Coryell W, et al. A prospective 12-year study of subsyndromal and syndromal depressive symptoms in unipolar major depressive disorders. Arch Gen Psychiatry. 1998;55:694–700.

    Article  PubMed  CAS  Google Scholar 

  7. Zimmerman M. Would broadening the diagnostic criteria for bipolar disorder do more harm than good? Implications from longitudinal studies of subthreshold conditions. J Clin Psychiatry. 2012;73:437–43.

    Article  PubMed  Google Scholar 

  8. Skodol AE, Stout RL, McGlashan TH, Grilo CM, Gunderson JG, Shea MT, et al. Co-occurrence of mood and personality disorders: a report from the Collaborative Longitudinal Personality Disorders Study (CLPS). Depress Anxiety. 1999;10:175–82.

    Article  PubMed  CAS  Google Scholar 

  9. Leichsenring F, Leibing E. The effectiveness of psychodynamic therapy and cognitive behavior therapy in the treatment of personality disorders: a meta-analysis. Am J Psychiatry. 2003;160:1223–32.

    Article  PubMed  Google Scholar 

  10. Leichsenring F, Rabung S. Effectiveness of long-term psychodynamic psychotherapy: a meta-analysis. JAMA. 2008;300:1551–65.

    Article  PubMed  CAS  Google Scholar 

  11. Matusiewicz AK, Hopwood CJ, Banducci AN, Lejuez CW. The effectiveness of cognitive behavioral therapy for personality disorders. Psychiatr Clin North Am. 2010;33:657–85.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Gunderson JG, Shea MT, Skodol AE, McGlashan TH, Morey LC, Stout RL, et al. The Collaborative Longitudinal Personality Disorders Study. I: development, aims, design, and sample characteristics. J Pers Disord. 2000;14:300–15.

    Article  PubMed  CAS  Google Scholar 

  13. Skodol AE, Shea MT, McGlashan TH, Gunderson JG, Morey LC, Sanislow CA, et al. The Collaborative Longitudinal Personality Disorders Study (CLPS): overview and implications. J Pers Disord. 2005;19:487–504.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR. The McLean study of adult development (MSAD): overview and implications of the first six years of prospective follow-up. J Pers Disord. 2005;19:505–23.

    Article  PubMed  Google Scholar 

  15. Grant BF, Stinson FS, Dawson DA, Chou SP, Ruan WJ, Pickering RP. Prevalence and co-occurrence of 12-month alcohol and drug use disorders and personality disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry. 2004;61:361–8.

    Article  PubMed  Google Scholar 

  16. Grant BF, Goldstein RB, Chou SP, Huang B, Stinson FS, Dawson DA, et al. Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Mol Psychiatry. 2009;14:1051–66.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  17. Cohen P, Crawford TN, Johnson JG, Kasen S. The children in the community study of developmental course of personality disorder. J Pers Disord. 2005;19:466–86.

    Article  PubMed  Google Scholar 

  18. Zanarini MC, Frankenburg FR, Sickel AE, Yong L. The diagnostic interview for DSM-IV personality disorders (DIPD-IV). Belmont: McLean Hospital; 1996.

    Google Scholar 

  19. First MB, Gibbon M, Spitzer RL, Williams JBW. Structured clinical interview for DSM-IV Axis I disorders – patient version (SCID-I/P). New York: Biometrics Research Department, New York State Psychiatric Institute; 1996.

    Google Scholar 

  20. Keller MB, Lavori PW, Friedman B, Nielsen E, Endicott J, McDonald-Scott P, et al. The Longitudinal Interval Follow-up Evaluation: a comprehensive method for assessing outcome in prospective longitudinal studies. Arch Gen Psychiatry. 1987;44:540–8.

    Article  PubMed  CAS  Google Scholar 

  21. Katz MM, Klerman GL. Introduction: overview of the clinical studies program. Am J Psychiatry. 1979;136:49–51.

    PubMed  CAS  Google Scholar 

  22. Zanarini MC, Gunderson JG, Frankenburg FR, Chauncey DL. The Revised Diagnostic Interview for Borderlines: discriminating BPD from other Axis II disorders. J Pers Disord. 1989;3:10–8.

    Article  Google Scholar 

  23. Grant BF, Dawson DA, Hasin DS. The alcohol use disorder and associated disabilities interview schedule—DSM-IV version (AUDADIS-IV). 2009.

    Google Scholar 

  24. Grilo CM, Sanislow CA, Shea MT, Skodol AE, Stout RL, Gunderson JG, et al. Two-year prospective naturalistic study of remission from major depressive disorder as a function of personality disorder comorbidity. J Consult Clin Psychol. 2005;73:78–85.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Grilo CM, Stout RL, Markowitz JC, Sanislow CA, Ansell EB, Skodol AE, et al. Personality disorders predict relapse after remission from an episode of major depressive disorder: a six-year prospective study. J Clin Psychiatry. 2010;71:1629–35.

    Article  PubMed  Google Scholar 

  26. Markowitz JC, Skodol AE, Petkova E, Xie H, Hellerstein DJ, Gunderson JG, et al. Longitudinal comparison of depressive personality disorder and dysthymic disorder. Compr Psychiatry. 2005;46:239–45.

    Article  PubMed  Google Scholar 

  27. Gunderson JG, Stout RL, Sanislow CA, Shea MT, McGlashan TH, Zanarini MC, et al. New episodes and new onsets of major depression in borderline and other personality disorders. J Affect Disord. 2008;111:40–5.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Gunderson JG, Stout RL, McGlashan TH, Shea MT, Morey LC, Grilo CM, et al. Ten year course of borderline personality disorder: psychopathology and function from the Collaborative Longitudinal Personality Disorders Study. Arch Gen Psychiatry. 2011;68:827–37.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR. Axis I comorbidity of borderline personality disorder: description of six-year course and prediction of time-to-remission. Am J Psychiatry. 2004;161:2108–14.

    Article  PubMed  Google Scholar 

  30. Cohen P, Cohen J. The clinician’s illusion. Arch Gen Psychiatry. 1984;41:1178–82.

    Article  PubMed  CAS  Google Scholar 

  31. Skodol AE, Grilo CM, Keyes KM, Geier T, Grant BF, Hasin DS. Relationship of personality disorders to the course of major depressive disorder in a nationally representative sample. Am J Psychiatry. 2011;168:257–64.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Johnson JG, Cohen P, Kasen S, Brook JS. Personality disorder traits associated with risk for unipolar depression during middle adulthood. Psychiatry Res. 2005;136:113–21.

    Article  PubMed  Google Scholar 

  33. Johnson JG, Cohen P, Kasen S, Brook JS. Personality disorders evident by early adulthood and risk for eating and weight problems during middle adulthood. Int J Eat Disord. 2006;39:184–92.

    Article  PubMed  Google Scholar 

  34. Johnson JG, Cohen P, Kasen S, Brook JS. Personality disorder traits evident by early adulthood and risk for anxiety disorders during middle adulthood. J Anxiety Disord. 2006;20:408–26.

    Article  PubMed  Google Scholar 

  35. Johnson JG, Cohen P, Skodol A, Oldham JM, Kasen S, Brook JS. Personality disorders in adolescence and risk of major mental disorders and suicidality during adulthood. Arch Gen Psychiatry. 1999;56:805–11.

    Article  PubMed  CAS  Google Scholar 

  36. Kasen S, Cohen P, Skodol AE, Johnson JG, Brook JS. Influence of child and adolescent psychiatric disorders on young adult personality disorder. Am J Psychiatry. 1999;156:1529–35.

    PubMed  CAS  Google Scholar 

  37. Kasen S, Cohen P, Skodol AE, Johnson JG, Smailes E, Brook JS. Childhood depression and adult personality disorder: alternative pathways of continuity. Arch Gen Psychiatry. 2001;58:231–6.

    Article  PubMed  CAS  Google Scholar 

  38. Gunderson JG, Weinberg I, Kueppenbender KD, Daversa M, Zanarini MC, Shea MT, et al. Descriptive and longitudinal observations on the relationship of borderline personality disorder (BPD) and bipolar disorders. Am J Psychiatry. 2006;163:1173–8.

    Article  PubMed  Google Scholar 

  39. Gunderson JG, Stout RL, Shea MT, Keuroghlian AS, Morey LC, Grilo CM, et al. Interactions of borderline personality disorder and mood disorders over ten years. J Clin Psychiatry. In press.

    Google Scholar 

  40. Siever LJ, Davis KL. A psychobiological perspective on the personality disorders. Am J Psychiatry. 1991;148:1647–58.

    PubMed  CAS  Google Scholar 

  41. Widiger TA. Personality and depression: assessment issues. In: Klein MH, Kupfer DJ, editors. Personality and depression: a current view, Mental health and psychopathology. New York: Guilford Press; 1993. p. 77–118.

    Google Scholar 

  42. McCrae RR, Costa PT. A five-factor theory of personality. In: Pervin LA, John OP, editors. Handbook of personality. Theory and research. 2nd ed. New York: Guilford; 1999. p. 139–53.

    Google Scholar 

  43. Clark LA, Watson D, Mineka S. Temperament, personality, and the mood and anxiety disorders. J Abnorm Psychol. 1994;103:103–16.

    Article  PubMed  CAS  Google Scholar 

  44. Skodol AE, Krueger RK, Bender DS, Morey LC, Clark LA, Bell CC, et al. Personality disorders in DSM-5 Section III. Focus. 2013;11:187–203.

    Article  Google Scholar 

  45. Watson D, Walker LM. The long-term stability and predictive validity of trait measures of affect. J Pers Soc Psychol. 1996;70:567–77.

    Article  PubMed  CAS  Google Scholar 

  46. Shea MT, Stout RL, Yen S, Pagano ME, Skodol AE, Morey LC, et al. Associations in the course of personality disorders and axis I disorders over time. J Abnorm Psychol. 2004;113:499–508.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Gunderson JG, Morey LC, Stout RL, Skodol AE, Shea MT, McGlashan TH, et al. Major depressive disorder and borderline personality disorder revisited: longitudinal interactions. J Clin Psychiatry. 2004;65:1049–56.

    Article  PubMed  Google Scholar 

  48. Gunderson JG, Daversa MT, Grilo CM, McGlashan TH, Zanarini MC, Shea MT, et al. Predictors of 2-year outcome for patients with borderline personality disorder. Am J Psychiatry. 2006;163:822–6.

    Article  PubMed  Google Scholar 

  49. Shea MT, Stout RL, Gunderson JG, Morey LC, Grilo CM, McGlashan TH, et al. Short-term diagnostic stability of schizotypal, borderline, avoidant, and obsessive compulsive personality disorders. Am J Psychiatry. 2002;159:2036–41.

    Article  PubMed  Google Scholar 

  50. White CN, Gunderson JG, Zanarini MC, Hudson JI. Family studies of borderline personality disorder: a review. Harv Rev Psychiatry. 2003;11:8–19.

    PubMed  Google Scholar 

  51. Zanarini MC, Barison LK, Frankenburg FR, Reich DB, Hudson JI. Family history study of the familial coaggregation of borderline personality disorder with axis I and nonborderline dramatic cluster axis II disorders. J Pers Disord. 2009;8:357–69.

    Article  Google Scholar 

  52. Coryell W, Endicott J, Reich T, Andreasen N, Keller M. A family study of bipolar II disorder. Br J Psychiatry. 1984;145:49–54.

    Article  PubMed  CAS  Google Scholar 

  53. Hadjipavlou G, Mok H, Yatham LN. Pharmacotherapy of bipolar II disorder: a critical review of current evidence. Bipolar Disord. 2004;6:14–25.

    Article  PubMed  CAS  Google Scholar 

  54. Benazzi F. Exploring aspects of DSM-IV interpersonal sensitivity in bipolar II. J Affect Disord. 2000;60:43–6.

    Article  PubMed  CAS  Google Scholar 

  55. Neves FS, Malloy-Diniz LF, Correa H. Suicidal behavior in bipolar disorder: what is the influence of psychiatric comorbidities. J Clin Psychiatry. 2009;70:13–8.

    Article  PubMed  Google Scholar 

  56. Tondo I, Lepri B, Baldessarini RJ. Suicidal risks among 2826 Sardinian major affective disorder patients. Acta Psychiatr Scand. 2007;116:395–402.

    Article  Google Scholar 

  57. Costa PT, McCrae RR. Stability and change in personality assessment: the revised NEO personality inventory in the year 2000. J Pers Assess. 1997;68:86–94.

    Article  PubMed  Google Scholar 

  58. Livesley WJ, Jackson DN, Schroeder ML. A study of the factorial structure of personality pathology. J Pers Disord. 1989;3:292–306.

    Article  Google Scholar 

  59. Clark LA. Manual for the schedule for nonadaptive and adaptive personality. Minneapolis: University of Minnesota Press; 1993.

    Google Scholar 

  60. Krueger RF, Derringer J, Markon KE, Watson D, Skodol AE. Initial construction of a maladaptive personality trait model and inventory for DSM-5. Psychol Med. 2012;42:1879–90.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  61. Bender DS, Skodol AE. Borderline personality as a self-other representational disturbance. J Pers Disord. 2007;21:500–17.

    Article  PubMed  Google Scholar 

  62. Bender DS, Morey LC, Skodol AE. Toward a model for assessing level of personality functioning in DSM-5, part I: a review of theory and methods. J Pers Assess. 2011;93:332–46.

    Article  PubMed  Google Scholar 

  63. Morey LC, Berghuis H, Bender DS, Verheul R, Krueger RF, Skodol AE. Toward a model for assessing level of personality functioning in DSM-5, part II: empirical articulation of a core dimension of personality pathology. J Pers Assess. 2011;93:347–53.

    Article  PubMed  Google Scholar 

  64. Morey LC, Bender DS, Skodol AE. Validating the proposed DSM-5 severity indicator for personality disorder. J Nerv Ment Dis. 2013;201:729–35.

    Article  PubMed  Google Scholar 

  65. Skodol AE, Shea MT, Yen S, White CN, Gunderson JG. Personality disorders and mood disorders: perspectives on diagnosis and classification from studies of longitudinal course and familial association. J Pers Disord. 2010;24:83–108.

    Article  PubMed  Google Scholar 

  66. Soloff PH, George A, Nathan S, Schulz PM, Cornelius JR, Herring J, et al. Amitriptyline versus haloperidol in borderlines: final outcomes and predictors of response. J Clin Psychopharmacol. 1989;9:238–46.

    Article  PubMed  CAS  Google Scholar 

  67. Feurino L, Silk KR. State of the art in the pharmacologic treatment of borderline personality disorder. Curr Psychiatry Rep. 2011;13:69–75.

    Article  PubMed  Google Scholar 

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Skodol, A.E. (2015). Borderline Personality Disorder and Mood Disorders: Longitudinal Course and Interactions. In: Choi-Kain, L., Gunderson, J. (eds) Borderline Personality and Mood Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1314-5_10

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