Abstract
Borderline personality disorder (BPD) is often misdiagnosed as a mood disorder, especially bipolar disorder. Mood disorder diagnostic variants that broaden the definitions of disorders often lead in clinical practice to the inappropriate use of medications, to a proliferation of medication changes, and sometimes to extensive and harmful polypharmacy aimed at addressing clinical problems that may well be the result of BPD, occurring either alone or as a comorbid condition. Examining the longitudinal course of BPD and comorbid mood disorders and their interactions over time may shed light not only on the disorder of primary importance but also, as a result, on the need to recognize and treat BPD with psychotherapy in order to achieve optimal outcomes in such cases. Results of four large-scale studies of the naturalistic, interactive course of personality disorders and mood disorders are reviewed in this chapter. The results indicate a strong interaction between BPD and major depressive disorder (MDD), suggesting overlapping psychopathologies and etiologies and weaker evidence for relationships between BPD and bipolar disorder. Research and clinical implications of these findings are discussed.
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References
Ruggero CJ, Zimmerman M, Chelminski I, Young D. Borderline personality disorder and the misdiagnosis of bipolar disorder. J Psychiatr Res. 2010;44:405–8.
Zimmerman M, Ruggero CJ, Chelminski I, Young D. Psychiatric diagnoses in patients previously diagnosed with bipolar disorder. J Clin Psychiatry. 2010;71:26–31.
Benazzi F. Bipolar II, disorder: epidemiology, diagnosis, and management. CNS Drugs. 2007;21:727–40.
Akiskal HS, Bourgeois ML, Angst J, Post R, Moller H, Hirschfield R. Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. J Affect Disord. 2000;59 Suppl 1:S5–30.
Akiskal HS, Pinto O. The evolving bipolar spectrum: prototypes I, II, III, and IV. Psychiatr Clin North Am. 1999;22:517–34.
Judd LL, Akiskal HS, Maser JD, Zeller PJ, Endicott J, Coryell W, et al. A prospective 12-year study of subsyndromal and syndromal depressive symptoms in unipolar major depressive disorders. Arch Gen Psychiatry. 1998;55:694–700.
Zimmerman M. Would broadening the diagnostic criteria for bipolar disorder do more harm than good? Implications from longitudinal studies of subthreshold conditions. J Clin Psychiatry. 2012;73:437–43.
Skodol AE, Stout RL, McGlashan TH, Grilo CM, Gunderson JG, Shea MT, et al. Co-occurrence of mood and personality disorders: a report from the Collaborative Longitudinal Personality Disorders Study (CLPS). Depress Anxiety. 1999;10:175–82.
Leichsenring F, Leibing E. The effectiveness of psychodynamic therapy and cognitive behavior therapy in the treatment of personality disorders: a meta-analysis. Am J Psychiatry. 2003;160:1223–32.
Leichsenring F, Rabung S. Effectiveness of long-term psychodynamic psychotherapy: a meta-analysis. JAMA. 2008;300:1551–65.
Matusiewicz AK, Hopwood CJ, Banducci AN, Lejuez CW. The effectiveness of cognitive behavioral therapy for personality disorders. Psychiatr Clin North Am. 2010;33:657–85.
Gunderson JG, Shea MT, Skodol AE, McGlashan TH, Morey LC, Stout RL, et al. The Collaborative Longitudinal Personality Disorders Study. I: development, aims, design, and sample characteristics. J Pers Disord. 2000;14:300–15.
Skodol AE, Shea MT, McGlashan TH, Gunderson JG, Morey LC, Sanislow CA, et al. The Collaborative Longitudinal Personality Disorders Study (CLPS): overview and implications. J Pers Disord. 2005;19:487–504.
Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR. The McLean study of adult development (MSAD): overview and implications of the first six years of prospective follow-up. J Pers Disord. 2005;19:505–23.
Grant BF, Stinson FS, Dawson DA, Chou SP, Ruan WJ, Pickering RP. Prevalence and co-occurrence of 12-month alcohol and drug use disorders and personality disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry. 2004;61:361–8.
Grant BF, Goldstein RB, Chou SP, Huang B, Stinson FS, Dawson DA, et al. Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Mol Psychiatry. 2009;14:1051–66.
Cohen P, Crawford TN, Johnson JG, Kasen S. The children in the community study of developmental course of personality disorder. J Pers Disord. 2005;19:466–86.
Zanarini MC, Frankenburg FR, Sickel AE, Yong L. The diagnostic interview for DSM-IV personality disorders (DIPD-IV). Belmont: McLean Hospital; 1996.
First MB, Gibbon M, Spitzer RL, Williams JBW. Structured clinical interview for DSM-IV Axis I disorders – patient version (SCID-I/P). New York: Biometrics Research Department, New York State Psychiatric Institute; 1996.
Keller MB, Lavori PW, Friedman B, Nielsen E, Endicott J, McDonald-Scott P, et al. The Longitudinal Interval Follow-up Evaluation: a comprehensive method for assessing outcome in prospective longitudinal studies. Arch Gen Psychiatry. 1987;44:540–8.
Katz MM, Klerman GL. Introduction: overview of the clinical studies program. Am J Psychiatry. 1979;136:49–51.
Zanarini MC, Gunderson JG, Frankenburg FR, Chauncey DL. The Revised Diagnostic Interview for Borderlines: discriminating BPD from other Axis II disorders. J Pers Disord. 1989;3:10–8.
Grant BF, Dawson DA, Hasin DS. The alcohol use disorder and associated disabilities interview schedule—DSM-IV version (AUDADIS-IV). 2009.
Grilo CM, Sanislow CA, Shea MT, Skodol AE, Stout RL, Gunderson JG, et al. Two-year prospective naturalistic study of remission from major depressive disorder as a function of personality disorder comorbidity. J Consult Clin Psychol. 2005;73:78–85.
Grilo CM, Stout RL, Markowitz JC, Sanislow CA, Ansell EB, Skodol AE, et al. Personality disorders predict relapse after remission from an episode of major depressive disorder: a six-year prospective study. J Clin Psychiatry. 2010;71:1629–35.
Markowitz JC, Skodol AE, Petkova E, Xie H, Hellerstein DJ, Gunderson JG, et al. Longitudinal comparison of depressive personality disorder and dysthymic disorder. Compr Psychiatry. 2005;46:239–45.
Gunderson JG, Stout RL, Sanislow CA, Shea MT, McGlashan TH, Zanarini MC, et al. New episodes and new onsets of major depression in borderline and other personality disorders. J Affect Disord. 2008;111:40–5.
Gunderson JG, Stout RL, McGlashan TH, Shea MT, Morey LC, Grilo CM, et al. Ten year course of borderline personality disorder: psychopathology and function from the Collaborative Longitudinal Personality Disorders Study. Arch Gen Psychiatry. 2011;68:827–37.
Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR. Axis I comorbidity of borderline personality disorder: description of six-year course and prediction of time-to-remission. Am J Psychiatry. 2004;161:2108–14.
Cohen P, Cohen J. The clinician’s illusion. Arch Gen Psychiatry. 1984;41:1178–82.
Skodol AE, Grilo CM, Keyes KM, Geier T, Grant BF, Hasin DS. Relationship of personality disorders to the course of major depressive disorder in a nationally representative sample. Am J Psychiatry. 2011;168:257–64.
Johnson JG, Cohen P, Kasen S, Brook JS. Personality disorder traits associated with risk for unipolar depression during middle adulthood. Psychiatry Res. 2005;136:113–21.
Johnson JG, Cohen P, Kasen S, Brook JS. Personality disorders evident by early adulthood and risk for eating and weight problems during middle adulthood. Int J Eat Disord. 2006;39:184–92.
Johnson JG, Cohen P, Kasen S, Brook JS. Personality disorder traits evident by early adulthood and risk for anxiety disorders during middle adulthood. J Anxiety Disord. 2006;20:408–26.
Johnson JG, Cohen P, Skodol A, Oldham JM, Kasen S, Brook JS. Personality disorders in adolescence and risk of major mental disorders and suicidality during adulthood. Arch Gen Psychiatry. 1999;56:805–11.
Kasen S, Cohen P, Skodol AE, Johnson JG, Brook JS. Influence of child and adolescent psychiatric disorders on young adult personality disorder. Am J Psychiatry. 1999;156:1529–35.
Kasen S, Cohen P, Skodol AE, Johnson JG, Smailes E, Brook JS. Childhood depression and adult personality disorder: alternative pathways of continuity. Arch Gen Psychiatry. 2001;58:231–6.
Gunderson JG, Weinberg I, Kueppenbender KD, Daversa M, Zanarini MC, Shea MT, et al. Descriptive and longitudinal observations on the relationship of borderline personality disorder (BPD) and bipolar disorders. Am J Psychiatry. 2006;163:1173–8.
Gunderson JG, Stout RL, Shea MT, Keuroghlian AS, Morey LC, Grilo CM, et al. Interactions of borderline personality disorder and mood disorders over ten years. J Clin Psychiatry. In press.
Siever LJ, Davis KL. A psychobiological perspective on the personality disorders. Am J Psychiatry. 1991;148:1647–58.
Widiger TA. Personality and depression: assessment issues. In: Klein MH, Kupfer DJ, editors. Personality and depression: a current view, Mental health and psychopathology. New York: Guilford Press; 1993. p. 77–118.
McCrae RR, Costa PT. A five-factor theory of personality. In: Pervin LA, John OP, editors. Handbook of personality. Theory and research. 2nd ed. New York: Guilford; 1999. p. 139–53.
Clark LA, Watson D, Mineka S. Temperament, personality, and the mood and anxiety disorders. J Abnorm Psychol. 1994;103:103–16.
Skodol AE, Krueger RK, Bender DS, Morey LC, Clark LA, Bell CC, et al. Personality disorders in DSM-5 Section III. Focus. 2013;11:187–203.
Watson D, Walker LM. The long-term stability and predictive validity of trait measures of affect. J Pers Soc Psychol. 1996;70:567–77.
Shea MT, Stout RL, Yen S, Pagano ME, Skodol AE, Morey LC, et al. Associations in the course of personality disorders and axis I disorders over time. J Abnorm Psychol. 2004;113:499–508.
Gunderson JG, Morey LC, Stout RL, Skodol AE, Shea MT, McGlashan TH, et al. Major depressive disorder and borderline personality disorder revisited: longitudinal interactions. J Clin Psychiatry. 2004;65:1049–56.
Gunderson JG, Daversa MT, Grilo CM, McGlashan TH, Zanarini MC, Shea MT, et al. Predictors of 2-year outcome for patients with borderline personality disorder. Am J Psychiatry. 2006;163:822–6.
Shea MT, Stout RL, Gunderson JG, Morey LC, Grilo CM, McGlashan TH, et al. Short-term diagnostic stability of schizotypal, borderline, avoidant, and obsessive compulsive personality disorders. Am J Psychiatry. 2002;159:2036–41.
White CN, Gunderson JG, Zanarini MC, Hudson JI. Family studies of borderline personality disorder: a review. Harv Rev Psychiatry. 2003;11:8–19.
Zanarini MC, Barison LK, Frankenburg FR, Reich DB, Hudson JI. Family history study of the familial coaggregation of borderline personality disorder with axis I and nonborderline dramatic cluster axis II disorders. J Pers Disord. 2009;8:357–69.
Coryell W, Endicott J, Reich T, Andreasen N, Keller M. A family study of bipolar II disorder. Br J Psychiatry. 1984;145:49–54.
Hadjipavlou G, Mok H, Yatham LN. Pharmacotherapy of bipolar II disorder: a critical review of current evidence. Bipolar Disord. 2004;6:14–25.
Benazzi F. Exploring aspects of DSM-IV interpersonal sensitivity in bipolar II. J Affect Disord. 2000;60:43–6.
Neves FS, Malloy-Diniz LF, Correa H. Suicidal behavior in bipolar disorder: what is the influence of psychiatric comorbidities. J Clin Psychiatry. 2009;70:13–8.
Tondo I, Lepri B, Baldessarini RJ. Suicidal risks among 2826 Sardinian major affective disorder patients. Acta Psychiatr Scand. 2007;116:395–402.
Costa PT, McCrae RR. Stability and change in personality assessment: the revised NEO personality inventory in the year 2000. J Pers Assess. 1997;68:86–94.
Livesley WJ, Jackson DN, Schroeder ML. A study of the factorial structure of personality pathology. J Pers Disord. 1989;3:292–306.
Clark LA. Manual for the schedule for nonadaptive and adaptive personality. Minneapolis: University of Minnesota Press; 1993.
Krueger RF, Derringer J, Markon KE, Watson D, Skodol AE. Initial construction of a maladaptive personality trait model and inventory for DSM-5. Psychol Med. 2012;42:1879–90.
Bender DS, Skodol AE. Borderline personality as a self-other representational disturbance. J Pers Disord. 2007;21:500–17.
Bender DS, Morey LC, Skodol AE. Toward a model for assessing level of personality functioning in DSM-5, part I: a review of theory and methods. J Pers Assess. 2011;93:332–46.
Morey LC, Berghuis H, Bender DS, Verheul R, Krueger RF, Skodol AE. Toward a model for assessing level of personality functioning in DSM-5, part II: empirical articulation of a core dimension of personality pathology. J Pers Assess. 2011;93:347–53.
Morey LC, Bender DS, Skodol AE. Validating the proposed DSM-5 severity indicator for personality disorder. J Nerv Ment Dis. 2013;201:729–35.
Skodol AE, Shea MT, Yen S, White CN, Gunderson JG. Personality disorders and mood disorders: perspectives on diagnosis and classification from studies of longitudinal course and familial association. J Pers Disord. 2010;24:83–108.
Soloff PH, George A, Nathan S, Schulz PM, Cornelius JR, Herring J, et al. Amitriptyline versus haloperidol in borderlines: final outcomes and predictors of response. J Clin Psychopharmacol. 1989;9:238–46.
Feurino L, Silk KR. State of the art in the pharmacologic treatment of borderline personality disorder. Curr Psychiatry Rep. 2011;13:69–75.
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Skodol, A.E. (2015). Borderline Personality Disorder and Mood Disorders: Longitudinal Course and Interactions. In: Choi-Kain, L., Gunderson, J. (eds) Borderline Personality and Mood Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1314-5_10
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