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Macrophages: Biology and Role in the Pathology of Diseases pp 425–443Cite as

Tumor-Associated Macrophages

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Abstract

Myeloid cells infiltrating tumor tissues are key promoters of the reactive inflammatory microenvironment. Tumor-associated macrophages (TAM) are functionally conditioned by neoplastic and stromal cells and differentiate into pro-tumoral effectors. TAM promote disease progression by supporting cancer cell survival, proliferation, invasion, angiogenesis, and suppression of adaptive immune responses. Clinical and experimental evidence has shown that high TAM density is mostly associated with poor patient prognosis and resistance to therapies. Targeting of myeloid cells in tumors is considered a promising therapeutic strategy: depletion of TAM or their “re-education” as antitumor effectors is under clinical investigation and hopefully will contribute to the efficacy of conventional anti-cancer treatments.

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Authors and Affiliations

  1. Humanitas Clinical and Research Institute, Rozzano, Milan, Italy

    Antonio Sica & Paola Allavena

  2. DiSCAFF, University of Piemonte Orientale A. Avogadro, Novara, Italy

    Antonio Sica & Laura Straus

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  1. Antonio Sica
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  2. Laura Straus
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  3. Paola Allavena
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Correspondence to Antonio Sica .

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  1. Singapore Immunology Network (SIgN) Biomedical Sciences Institutes, A*STAR, Singapore, Singapore

    Subhra K. Biswas

  2. IRCCS Humanitas Clinical and Research Institute, Humanitas University, Rozzano, Italy

    Alberto Mantovani

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Sica, A., Straus, L., Allavena, P. (2014). Tumor-Associated Macrophages. In: Biswas, S., Mantovani, A. (eds) Macrophages: Biology and Role in the Pathology of Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1311-4_20

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