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Macrophages Govern the Progression and Termination of Inflammation in Atherosclerosis and Metabolic Diseases

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Macrophages: Biology and Role in the Pathology of Diseases

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Abstract

Atherosclerosis is a chronic inflammatory, nonresolving disease of the vasculature driven by persistent accumulation of lipoproteins (LPs) in the matrix beneath the endothelial cell layer of blood vessels. LP deposition leads to the recruitment of monocytes that give rise to macrophages. Macrophages derived from these recruited monocytes can either participate in a pro-resolving tissue restorative program (i.e., early atherogenesis) or a maladaptive, nonresolving inflammatory response that expands the subendothelial layer due to the accumulation of cells, lipid, and matrix (i.e., advanced atherosclerosis). Some advanced lesions form a necrotic core, triggering acute thrombotic vascular disease, including myocardial infarction, stroke, and sudden cardiac death. This book chapter will discuss the complex roles of macrophages in atherosclerosis and metabolic disease and provide insight into novel treatment strategies that can harness macrophages to promote tissue resolution and repair.

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Authors and Affiliations

  1. Department of Medicine, Columbia University, New York, NY, 10032, USA

    Gabrielle Fredman & Ira Tabas

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  1. Gabrielle Fredman
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  2. Ira Tabas
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Correspondence to Gabrielle Fredman .

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Editors and Affiliations

  1. Singapore Immunology Network (SIgN) Biomedical Sciences Institutes, A*STAR, Singapore, Singapore

    Subhra K. Biswas

  2. IRCCS Humanitas Clinical and Research Institute, Humanitas University, Rozzano, Italy

    Alberto Mantovani

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Fredman, G., Tabas, I. (2014). Macrophages Govern the Progression and Termination of Inflammation in Atherosclerosis and Metabolic Diseases. In: Biswas, S., Mantovani, A. (eds) Macrophages: Biology and Role in the Pathology of Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1311-4_18

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