Abstract
Nonrenal solid organ transplantation is often complicated by acute kidney injury (AKI); it occurs in about one in four recipients of either liver or cardiac transplants in the perioperative period and is associated with increased morbidity, mortality, and length of hospital stay. A unique set of risk factors associates with kidney and electrolyte disorders among end-stage liver disease patients and liver transplant recipients. A slightly different set of perioperative factors determines the risk of AKI after cardiac transplant. There is also some degree of commonality across all of these patients in terms of long-term risk of chronic kidney disease, effects of calcineurin inhibitors on the kidney, and considerations for kidney transplantation. In this review, we discuss clinical approaches to diagnosis and management of renal issues in liver and cardiac transplantation. We discuss challenges in the measurement of renal function, the spectrum of renal injury over short and long term, and clinically relevant aspects of renal replacement therapy including transplantation.
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Srinivas, T.R., Flechner, S.M. (2015). The Kidney in Nonrenal Solid Organ Transplantation: Liver and Heart. In: Thakar, C., Parikh, C. (eds) Perioperative Kidney Injury. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1273-5_14
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DOI: https://doi.org/10.1007/978-1-4939-1273-5_14
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