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Relationship Between Substrate Metabolism and Cardiac Efficiency

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Book cover Cardiac Energy Metabolism in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 11))

Abstract

The heart requires large amounts of energy to sustain its continuous pumping activity, and is highly dependent on an optimal energy substrate metabolism with efficient ATP generation and utilization. As ATP is primarily derived from mitochondrial oxidative phosphorylation, myocardial oxygen consumption (MVO2) can be used to measure the rate of energy expenditure of the heart. Although cardiac efficiency is an ambiguous term, it commonly embraces the relationship between MVO2 and cardiac work. There is close coupling between myocardial oxygen consumption and the factors that determine cardiac work such as wall stress (influenced by pre- and after-load), heart rate and contractile state. Substrate metabolism may also affect myocardial oxygen consumption, and has through this been considered to contribute to the pathogenesis of cardiac dysfunction in several forms of heart disease. Part of the beneficial effect of metabolic therapies may also relate to improvement of cardiac efficiency. The focus in this chapter will therefore be on our current understanding of how myocardial substrate supply and/or utilization contribute to altered cardiac efficiency.

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Acknowledgments

The author would like to thank Truls Myrmel and Terje S. Larsen for feedback on the manuscript, and also Neoma T. Boardman for her linguistic assistance.

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Authors and Affiliations

  1. Cardiovascular Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037, Tromsø, Norway

    Ellen Aasum Ph.D.

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  1. Ellen Aasum Ph.D.
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Correspondence to Ellen Aasum Ph.D. .

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Editors and Affiliations

  1. Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

    Gary D. Lopaschuk

  2. University of Manitoba, Institute of Cardiovascular Sciences, St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Aasum, E. (2014). Relationship Between Substrate Metabolism and Cardiac Efficiency. In: Lopaschuk, G., Dhalla, N. (eds) Cardiac Energy Metabolism in Health and Disease. Advances in Biochemistry in Health and Disease, vol 11. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1227-8_7

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