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Transcriptional Control of Mitochondrial Biogenesis and Maturation

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Cardiac Energy Metabolism in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 11))

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Abstract

The mitochondrion is the main site for ATP production in the adult heart and comprises up to 40 % of the cardiac myocyte volume. It is now recognized that a complex network of nuclear transcription factors is essential for the coordinated regulation of mitochondrial biogenesis, maturation and function. These transcription factors guide developmental changes in mitochondrial number, structure, and dynamics as well as respond to various physiologic and pathophysiologic cues to meet the energetic needs of the adult heart. The peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) orchestrates the actions of many of these transcription factors to maintain a high level of mitochondrial ATP production. There is increasing evidence that during the development of cardiac hypertrophy and in the failing heart, the activity of this network, including PGC-1, is altered. This review summarizes our current understanding of the perturbations in the gene regulatory pathways that occur during the development of heart failure. An appreciation of the role this regulatory circuitry serves in the regulation of cardiac energy metabolism may guide the development of novel therapeutic targets aimed at the metabolic disturbances that presage heart failure.

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Acknowledgments

This work was supported by NIH grants (R01 DK045416, R01 HL058493, R01 HL101189 [D.P.K.]). We thank Lorenzo Thomas for help with manuscript preparation.

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Authors and Affiliations

  1. Diabetes and Obesity Research Center, Cardiovascular Pathobiology Program, Sanford-Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL, 32827, USA

    Rick B. Vega, Teresa C. Leone & Daniel P. Kelly M.D.

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  1. Rick B. Vega
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  2. Teresa C. Leone
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  3. Daniel P. Kelly M.D.
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Correspondence to Daniel P. Kelly M.D. .

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Editors and Affiliations

  1. Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

    Gary D. Lopaschuk

  2. University of Manitoba, Institute of Cardiovascular Sciences, St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Vega, R.B., Leone, T.C., Kelly, D.P. (2014). Transcriptional Control of Mitochondrial Biogenesis and Maturation. In: Lopaschuk, G., Dhalla, N. (eds) Cardiac Energy Metabolism in Health and Disease. Advances in Biochemistry in Health and Disease, vol 11. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1227-8_6

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