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Lipoproteins: A Source of Cardiac Lipids

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Cardiac Energy Metabolism in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 11))

Abstract

Lipids are the major substrate for cardiac ATP production and they are derived from adipose tissue or lipoprotein triglycerides. Lipoproteins are synthesized in the liver and they obtain their mature form following interaction with enzymes that are present in the circulation. Lipoprotein-derived fatty acids are released by lipoprotein lipase and are then taken up by cardiomyocytes either passively or via fatty acid receptors, such as CD36. Uptake of remnant lipoproteins via cardiomyocyte lipoprotein receptors is also possible. Besides fatty acids, other hydrophobic molecules such as cholesteryl esters, retinyl esters and vitamins are delivered by lipoproteins to the heart. While lipids are important for normal cardiac function, excessive lipid uptake, also known as lipotoxicity, may lead to cardiac abnormalities. This chapter focuses on the role of lipoproteins in providing fatty acids and other essential lipids to the heart in healthy conditions as well as in cardiac disease.

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Authors and Affiliations

  1. Department of Pharmacology, Center for Translational Medicine, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, PA, 19140, USA

    Konstantinos Drosatos

  2. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Langone Medical Center, 522 First Avenue, New York, NY, 10016, USA

    Ira J. Goldberg M.D.

Authors
  1. Konstantinos Drosatos
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  2. Ira J. Goldberg M.D.
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Correspondence to Ira J. Goldberg M.D. .

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  1. Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

    Gary D. Lopaschuk

  2. University of Manitoba, Institute of Cardiovascular Sciences, St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Drosatos, K., Goldberg, I.J. (2014). Lipoproteins: A Source of Cardiac Lipids. In: Lopaschuk, G., Dhalla, N. (eds) Cardiac Energy Metabolism in Health and Disease. Advances in Biochemistry in Health and Disease, vol 11. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1227-8_2

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