Effects of Bariatric Surgery on Non-metabolic Disease

  • John B. Dixon


This chapter provides an overview of the effect of bariatric surgery on a range of obesity-related comorbidities that may not be considered strictly metabolic or inflammatory. This is an arbitrary distinction because there will very likely be metabolic–inflammatory components to all obesity-related comorbidity and physical–weight–pressure-generated effects even in those considered to be metabolic–inflammatory. The chapter focuses on comorbidity beyond type 2 diabetes, lipid disorders, and their effect on cardiovascular risk. Obesity comorbidity should have the following consistent features: the condition should increase in prevalence with increasing obesity, there should be plausible mechanisms that link obesity with the comorbid condition, and there should be an improvement or attenuation of the disease progression in association with weight loss. It is important to consider these criteria carefully as we need to be able to provide our obese patients with realistic expectations about conditions that are likely to improve and possibly even go into remission, and those that may not, following bariatric surgery.


Obstructive Sleep Apnea Bariatric Surgery Gastric Bypass Stress Urinary Incontinence Sleeve Gastrectomy 
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  1. 1.
    Dixon AE, Pratley RE, Forgione PM, Kaminsky DA, Whittaker-Leclair LA, Griffes LA, et al. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J Allergy Clin Immunol. 2011;128(3):508–15.e1–2.PubMedCrossRefPubMedCentralGoogle Scholar
  2. 2.
    Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569–78.PubMedCrossRefGoogle Scholar
  3. 3.
    Sjostrom L, Gummesson A, Sjostrom CD, Narbro K, Peltonen M, Wedel H, et al. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 2009;10(7):653–62.PubMedCrossRefGoogle Scholar
  4. 4.
    Sugerman HJ. Effects of increased intra-abdominal pressure in severe obesity. Surg Clin North Am. 2001;81(5):1063–75, vi.PubMedCrossRefGoogle Scholar
  5. 5.
    Sugerman HJ, Felton 3rd WL, Sismanis A, Kellum JM, DeMaria EJ, Sugerman EL. Gastric surgery for pseudotumor cerebri associated with severe obesity. Ann Surg. 1999;229(5):634–40; discussion 640–632.PubMedCrossRefPubMedCentralGoogle Scholar
  6. 6.
    Bond DS, Vithiananthan S, Nash JM, Thomas JG, Wing RR. Improvement of migraine headaches in severely obese patients after bariatric surgery. Neurology. 2011;76(13):1135–8.PubMedCrossRefPubMedCentralGoogle Scholar
  7. 7.
    Erlinger S. Gallstones in obesity and weight loss. Eur J Gastroenterol Hepatol. 2000;12(12):1347–52.PubMedCrossRefGoogle Scholar
  8. 8.
    Straznicky N, Grassi G, Esler M, Lambert G, Dixon J, Lambert E, et al. European society of hypertension working group on obesity antihypertensive effects of weight loss: myth or reality? J Hypertens. 2010;28:637–43.PubMedCrossRefGoogle Scholar
  9. 9.
    Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724–37.PubMedCrossRefGoogle Scholar
  10. 10.
    Gagliardi AC, Miname MH, Santos RD. Uric acid: a marker of increased cardiovascular risk. Atherosclerosis. 2009;202(1):11–7.PubMedCrossRefGoogle Scholar
  11. 11.
    Krishnan E, Lienesch D, Kwoh CK. Gout in ambulatory care settings in the United States. J Rheumatol. 2008;35(3):498–501.PubMedGoogle Scholar
  12. 12.
    Sjostrom L, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Carlsson B, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.PubMedCrossRefGoogle Scholar
  13. 13.
    Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005–23.PubMedCrossRefGoogle Scholar
  14. 14.
    Dixon JB. Surgical treatment for obesity and its impact on non-alcoholic steatohepatitis. Clin Liver Dis. 2007;11(1):141–54.PubMedCrossRefGoogle Scholar
  15. 15.
    Wluka AE, Lombard CB, Cicuttini FM. Tackling obesity in knee osteoarthritis. Nat Rev Rheumatol. 2013;9:225–35.PubMedCrossRefGoogle Scholar
  16. 16.
    Dixon JB, Dixon ME, O’Brien PE. Quality of life after lap-band placement: influence of time, weight loss, and comorbidities. Obes Res. 2001;9(11):713–21.PubMedCrossRefGoogle Scholar
  17. 17.
    Gill RS, Al-Adra DP, Shi X, Sharma AM, Birch DW, Karmali S. The benefits of bariatric surgery in obese patients with hip and knee osteoarthritis: a systematic review. Obes Rev. 2011;12(12):1083–9.PubMedCrossRefGoogle Scholar
  18. 18.
    Maggard MA, Yermilov I, Li Z, Maglione M, Newberry S, Suttorp M, Hilton L, Santry HP, Morton JM, Livingston EH, Shekelle PG. Pregnancy and fertility following bariatric surgery: a systematic review. JAMA. 2008;300(19):2286–96.PubMedCrossRefGoogle Scholar
  19. 19.
    Greenburg DL, Lettieri CJ, Eliasson AH. Effects of surgical weight loss on measures of obstructive sleep apnea: a meta-analysis. Am J Med. 2009;122(6):535–42.PubMedCrossRefGoogle Scholar
  20. 20.
    Marik PE. The malignant obesity hypoventilation syndrome (mohs). Obes Rev. 2012;13(10):902–9.PubMedCrossRefGoogle Scholar
  21. 21.
    Woodard G, Ahmed S, Podelski V, Hernandez-Boussard T, Presti J, Morton JM. Effect of Roux-en-Y gastric bypass on testosterone and prostate-specific antigen. Br J Surg. 2012;99(5):693–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Clinical Obesity ResearchBaker IDI Heart and Diabetes InstituteMelbourneAustralia

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