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Effects of Bariatric Surgery on Non-metabolic Disease

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The ASMBS Textbook of Bariatric Surgery

Abstract

This chapter provides an overview of the effect of bariatric surgery on a range of obesity-related comorbidities that may not be considered strictly metabolic or inflammatory. This is an arbitrary distinction because there will very likely be metabolic–inflammatory components to all obesity-related comorbidity and physical–weight–pressure-generated effects even in those considered to be metabolic–inflammatory. The chapter focuses on comorbidity beyond type 2 diabetes, lipid disorders, and their effect on cardiovascular risk. Obesity comorbidity should have the following consistent features: the condition should increase in prevalence with increasing obesity, there should be plausible mechanisms that link obesity with the comorbid condition, and there should be an improvement or attenuation of the disease progression in association with weight loss. It is important to consider these criteria carefully as we need to be able to provide our obese patients with realistic expectations about conditions that are likely to improve and possibly even go into remission, and those that may not, following bariatric surgery.

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References

  1. Dixon AE, Pratley RE, Forgione PM, Kaminsky DA, Whittaker-Leclair LA, Griffes LA, et al. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J Allergy Clin Immunol. 2011;128(3):508–15.e1–2.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569–78.

    Article  PubMed  Google Scholar 

  3. Sjostrom L, Gummesson A, Sjostrom CD, Narbro K, Peltonen M, Wedel H, et al. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 2009;10(7):653–62.

    Article  PubMed  Google Scholar 

  4. Sugerman HJ. Effects of increased intra-abdominal pressure in severe obesity. Surg Clin North Am. 2001;81(5):1063–75, vi.

    Article  PubMed  CAS  Google Scholar 

  5. Sugerman HJ, Felton 3rd WL, Sismanis A, Kellum JM, DeMaria EJ, Sugerman EL. Gastric surgery for pseudotumor cerebri associated with severe obesity. Ann Surg. 1999;229(5):634–40; discussion 640–632.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  6. Bond DS, Vithiananthan S, Nash JM, Thomas JG, Wing RR. Improvement of migraine headaches in severely obese patients after bariatric surgery. Neurology. 2011;76(13):1135–8.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  7. Erlinger S. Gallstones in obesity and weight loss. Eur J Gastroenterol Hepatol. 2000;12(12):1347–52.

    Article  PubMed  CAS  Google Scholar 

  8. Straznicky N, Grassi G, Esler M, Lambert G, Dixon J, Lambert E, et al. European society of hypertension working group on obesity antihypertensive effects of weight loss: myth or reality? J Hypertens. 2010;28:637–43.

    Article  PubMed  CAS  Google Scholar 

  9. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724–37.

    Article  PubMed  CAS  Google Scholar 

  10. Gagliardi AC, Miname MH, Santos RD. Uric acid: a marker of increased cardiovascular risk. Atherosclerosis. 2009;202(1):11–7.

    Article  PubMed  CAS  Google Scholar 

  11. Krishnan E, Lienesch D, Kwoh CK. Gout in ambulatory care settings in the United States. J Rheumatol. 2008;35(3):498–501.

    PubMed  Google Scholar 

  12. Sjostrom L, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Carlsson B, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.

    Article  PubMed  Google Scholar 

  13. Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005–23.

    Article  PubMed  Google Scholar 

  14. Dixon JB. Surgical treatment for obesity and its impact on non-alcoholic steatohepatitis. Clin Liver Dis. 2007;11(1):141–54.

    Article  PubMed  Google Scholar 

  15. Wluka AE, Lombard CB, Cicuttini FM. Tackling obesity in knee osteoarthritis. Nat Rev Rheumatol. 2013;9:225–35.

    Article  PubMed  Google Scholar 

  16. Dixon JB, Dixon ME, O’Brien PE. Quality of life after lap-band placement: influence of time, weight loss, and comorbidities. Obes Res. 2001;9(11):713–21.

    Article  PubMed  CAS  Google Scholar 

  17. Gill RS, Al-Adra DP, Shi X, Sharma AM, Birch DW, Karmali S. The benefits of bariatric surgery in obese patients with hip and knee osteoarthritis: a systematic review. Obes Rev. 2011;12(12):1083–9.

    Article  PubMed  CAS  Google Scholar 

  18. Maggard MA, Yermilov I, Li Z, Maglione M, Newberry S, Suttorp M, Hilton L, Santry HP, Morton JM, Livingston EH, Shekelle PG. Pregnancy and fertility following bariatric surgery: a systematic review. JAMA. 2008;300(19):2286–96.

    Article  PubMed  CAS  Google Scholar 

  19. Greenburg DL, Lettieri CJ, Eliasson AH. Effects of surgical weight loss on measures of obstructive sleep apnea: a meta-analysis. Am J Med. 2009;122(6):535–42.

    Article  PubMed  Google Scholar 

  20. Marik PE. The malignant obesity hypoventilation syndrome (mohs). Obes Rev. 2012;13(10):902–9.

    Article  PubMed  CAS  Google Scholar 

  21. Woodard G, Ahmed S, Podelski V, Hernandez-Boussard T, Presti J, Morton JM. Effect of Roux-en-Y gastric bypass on testosterone and prostate-specific antigen. Br J Surg. 2012;99(5):693–8.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to John B. Dixon MBBS, PhD, FRACGP, FRCP Edin .

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Dixon, J.B. (2015). Effects of Bariatric Surgery on Non-metabolic Disease. In: Nguyen, N., Blackstone, R., Morton, J., Ponce, J., Rosenthal, R. (eds) The ASMBS Textbook of Bariatric Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1206-3_33

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  • DOI: https://doi.org/10.1007/978-1-4939-1206-3_33

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  • Publisher Name: Springer, New York, NY

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  • Online ISBN: 978-1-4939-1206-3

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