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Restless Legs and PLMD

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Abstract

Restless legs syndrome (RLS) is a neurologic condition that involves an urge to move legs typically accompanied by symptoms of “creeping,” “crawling,” “tingling,” or “aching”. Symptoms can occasionally involve the arms or torso as well. One of the central aspects of the condition is that these dysesthesias occur more often at rest and in the evening, and are temporarily improved with movement. The relief with movement is often immediate. This can cause initiation and maintenance insomnia resulting in excessive daytime sleepiness.

The prevalence of RLS is approximately 10 % and the prevalence of moderate to severe sufferers is approximately 3 %. The condition is diagnosed primarily by history and has multiple treatment options, ranging from lifestyle changes, medication adjustment, and medication treatment.

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References

  1. Allen RP, Earley CJ. Restless legs syndrome: a review of clinical and pathophysiologic features. J Clin Neurophysiol. 2001;18(2):128–47.

    Article  PubMed  CAS  Google Scholar 

  2. Ekbom K, Ulfberg J. Restless legs syndrome. J Intern Med. 2009;266(5):419–31.

    Article  PubMed  CAS  Google Scholar 

  3. Phillips B, et al. Epidemiology of restless legs symptoms in adults. Arch Intern Med. 2000;160(14):2137–41.

    Article  PubMed  CAS  Google Scholar 

  4. Phillips B, et al. Prevalence and correlates of restless legs syndrome: results from the 2005 National Sleep Foundation Poll. Chest. 2006;129(1):76–80.

    Article  PubMed  Google Scholar 

  5. Lavigne GJ, Montplaisir JY. Restless legs syndrome and sleep bruxism: prevalence and association among Canadians. Sleep. 1994;17(8):739–43.

    PubMed  CAS  Google Scholar 

  6. Earley CJ, et al. The treatment of restless legs syndrome with intravenous iron dextran. Sleep Med. 2004;5(3):231–5.

    Article  PubMed  Google Scholar 

  7. Earley CJ, et al. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology. 2000;54(8):1698–700.

    Article  PubMed  CAS  Google Scholar 

  8. Schmidauer C, et al. Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome. Ann Neurol. 2005;58(4):630–4.

    Article  PubMed  Google Scholar 

  9. Godau J, et al. Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome. Mov Disord. 2007;22(2):187–92.

    Article  PubMed  Google Scholar 

  10. Allen RP, Earley CJ. Defing the pherotype of the resthese legs sychrome (RLS) using a of symptom onset. Sleep Med. 2000;1(1)11–19.

    Google Scholar 

  11. Allen RP, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4(2):101–19.

    Article  PubMed  Google Scholar 

  12. Kemlink D, et al. Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13. Neurogenetics. 2008;9(2):75–82.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  13. Levchenko A, et al. Autosomal-dominant locus for Restless Legs Syndrome in French-Canadians on chromosome 16p12.1. Mov Disord. 2009;24(1):40–50.

    Article  PubMed  Google Scholar 

  14. Winkelmann J, et al. Genome wide associate study indenfies novel reflects legs systome susceptbadly loci on 2p14 and 16q12.1. Plos Gnet 2011;7(7). Epub 2011 July 14.

    Google Scholar 

  15. Stefanssan H, et al. A genetic using factor for periodic lab rements in slep. N Engl J Med. 2007;357(7):639:47.

    Google Scholar 

  16. Manconi M, et al. Restless legs syndrome and pregnancy. Neurology. 2004;63(6):1065–9.

    Article  PubMed  CAS  Google Scholar 

  17. Wetter TC, et al. Polysomnographic sleep measures in patients with uremic and idiopathic restless legs syndrome. Mov Disord. 1998;13(5):820–4.

    Article  PubMed  CAS  Google Scholar 

  18. Yasuda T, et al. Restless legs syndrome treated successfully by kidney transplantation—a case report. Clin Transpl. 1986;138.

    Google Scholar 

  19. Yunus MB, Aldag JC. Restless legs syndrome and leg cramps in fibromyalgia syndrome: a controlled study. BMJ. 1996;312(7042):1339.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  20. Weinstock LB, et al. Crohn's disease is associated with restless legs syndrome. Inflamm Bowel Dis. 2010;16(2):275–9.

    Article  PubMed  Google Scholar 

  21. Gjevre JA, Taylor Gjevre RM. Restless legs syndrome as a comorbidity in rheumatoid arthritis. Autoimmune Dis. 2013;2013:352782.

    PubMed  PubMed Central  Google Scholar 

  22. Allen RP, et al. Factor analysis of the International Restless Legs Syndrome Study Group’s scale for restless legs severity. Sleep Med. 2003;4(2):133–5.

    Article  PubMed  Google Scholar 

  23. Walters AS, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003;4(2):121–32.

    Article  PubMed  Google Scholar 

  24. Silber MH, et al. An algorithm for the management of restless legs syndrome. Mayo Clin Proc. 2004;79(7):916–22.

    Article  PubMed  Google Scholar 

  25. Wang J, et al. Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: a randomized, double-blind, placebo-controlled study. Sleep Med. 2009;10(9):973–5.

    Article  PubMed  Google Scholar 

  26. Bayard M, et al. Bupropion and restless legs syndrome: a randomized controlled trial. J Am Board Fam Med. 2011;24(4):422–8.

    Article  PubMed  Google Scholar 

  27. Garcia-Borreguero D, et al. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group. Sleep Med. 2013;14(7):675–84.

    Article  PubMed  Google Scholar 

  28. Allen RP, et al. Restless legs syndrome (RLS) augmentation associated with dopamine agonist and levodopa usage in a community sample. Sleep Med. 2011;12(5):431–9.

    Article  PubMed  Google Scholar 

  29. Inoue Y, et al. Efficacy, safety and risk of augmentation of rotigotine for treating restless legs syndrome. Prog Neuropsychopharmacol Biol Psychiatry. 2013;40:326–33.

    Article  PubMed  CAS  Google Scholar 

  30. Garcia-Borreguero D, Williams AM. Dopaminergic augmentation of restless legs syndrome. Sleep Med Rev. 2010;14(5):339–46.

    Google Scholar 

  31. Danoff SK, et al. Pleuropulmonary disease due to pergolide use for restless legs syndrome. Chest. 2001;120(1):313–6.

    Google Scholar 

  32. Cornelius JR, et al. Impulse control disorders with the use of dopaminergic agents in restless legs syndrome: a case-control study. Sleep. 2010;33(1):81–7.

    Google Scholar 

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Correspondence to Clete A. Kushida M.D., Ph.D. .

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© 2014 Springer Science+Business Media New York

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Verma, N., Kushida, C.A. (2014). Restless Legs and PLMD. In: Pagel, J., Pandi-Perumal, S. (eds) Primary Care Sleep Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1185-1_30

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  • DOI: https://doi.org/10.1007/978-1-4939-1185-1_30

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  • Publisher Name: Springer, New York, NY

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