Skip to main content

Sleep in the Elderly

  • Chapter
  • First Online:
  • 1354 Accesses

Abstract

Sleep complaints are highly prevalent in older adults, and typically present to the primary care clinician. They are associated with potentially catastrophic consequences, such as injuries from falls and motor vehicle accidents. Typical changes in sleep associated with age include delayed sleep onset, frequent awakenings, and a phase shift to earlier sleep and earlier awakening. Some primary sleep disorders are more common in older adults, such as restless legs syndrome and sleep-disordered breathing. In most cases, the cause of sleep complaints is multifactorial, involving primary sleep disorders, comorbid medical and psychiatric illnesses, and the effects of medications and polypharmacy. Whenever possible, treatment of insomnia in older adults should include treatment of contributing factors, adjustment of current medications, and non-pharmacologic measures, such as exercise. Medications to treat insomnia should be selected and used judiciously, utilizing the lowest effective doses. The evaluation and treatment of sleep disturbances requires special considerations in the growing population of individuals with dementia. When sleep complaints are successfully addressed, there is often an increase in quality of life, both for the patient and family members/caregivers.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

AD:

Alzheimer’s disease

BLT:

Bright light therapy

CBT:

Cognitive behavioral therapy

EEG:

Electroencephalography

EPESE:

Established populations for epidemiologic studies of the elderly

HEDIS:

Health plan employer data information set

LBD:

Lewy body dementia

OTC:

Over the counter

PDD:

Parkinson’s disease dementia

PLMS:

Periodic limb movements of sleep

PSQI:

Pittsburgh sleep quality index

RBD:

REM sleep behavior disorder

REM:

Rapid eye movement

RLS:

Restless legs syndrome

SDB:

Sleep disordered breathing

References

  1. U.S. Census Bureau. 2010 Census briefs: the older population: 2010. C2010BR-09. November, 2011. Report no.: Contract no.: C2010BR-09.

    Google Scholar 

  2. U.S. Census Bureau. The next four decades. The older population in the United States: 2010 to 2050. Population Estimates and Projections. pp 25–1138

    Google Scholar 

  3. Colwill JM, Cultice JM, Kruse RL. Will generalist physician supply meet demands of an increasing and aging population? Health Aff (Millwood). 2008;27(3):w232–41. Epub 2008/05/01.

    Article  Google Scholar 

  4. Monjan AA. Sleep in Aging. In: Pandi-Perumal DLSR, editor. Sleep disorders: their impact on public health. Abingdon: Informa Healthcare; 2007. p. 59–65.

    Google Scholar 

  5. Foley DJ, Monjan AA, Brown SL, Simonsick EM, Wallace RB, Blazer DG. Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep. 1995;18(6):425–32. Epub 1995/07/01.

    PubMed  CAS  Google Scholar 

  6. Foley DJ, Monjan A, Simonsick EM, Wallace RB, Blazer DG. Incidence and remission of insomnia among elderly adults: an epidemiologic study of 6,800 persons over three years. Sleep. 1999;22 Suppl 2:S366–72. Epub 1999/07/08.

    PubMed  Google Scholar 

  7. Blackwell T, Yaffe K, Ancoli-Israel S, Schneider JL, Cauley JA, Hillier TA, et al. Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci. 2006;61(4):405–10. Epub 2006/04/14.

    Article  PubMed  Google Scholar 

  8. Roth T, Ancoli-Israel S. Daytime consequences and correlates of insomnia in the United States: results of the 1991 National Sleep Foundation Survey. II. Sleep. 1999;22 Suppl 2:S354–8. Epub 1999/07/08.

    PubMed  Google Scholar 

  9. Dam TT, Ewing S, Ancoli-Israel S, Ensrud K, Redline S, Stone K. Association between sleep and physical function in older men: the osteoporotic fractures in men sleep study. J Am Geriatr Soc. 2008;56(9):1665–73. Epub 2008/09/02.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Ford DE, Kamerow DB. Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? J Am Med Assoc. 1989;262(11):1479–84.

    Article  CAS  Google Scholar 

  11. Dew MA, Hoch CC, Buysse DJ, Monk TH, Begley AE, Houck PR, et al. Healthy older adults' sleep predicts all-cause mortality at 4 to 19 years of follow-up. Psychosom Med. 2003;65(1):63–73. Epub 2003/01/30.

    Article  PubMed  Google Scholar 

  12. Newman AB, Spiekerman CF, Enright P, Lefkowitz D, Manolio T, Reynolds CF, et al. Daytime sleepiness predicts mortality and cardiovascular disease in older adults. The Cardiovascular Health Study Research Group. J Am Geriatr Soc. 2000;48(2):115–23. Epub 2000/02/22.

    PubMed  CAS  Google Scholar 

  13. Robillard R, Prince F, Filipini D, Carrier J. Aging worsens the effects of sleep deprivation on postural control. PLoS One. 2011;6(12):e28731. Epub 2011/12/14.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  14. Brassington GS, King AC, Bliwise DL. Sleep problems as a risk factor for falls in a sample of community-dwelling adults aged 64–99 years. J Am Geriatr Soc. 2000;48(10):1234–40. Epub 2000/10/19.

    PubMed  CAS  Google Scholar 

  15. Stone KL, Ancoli-Israel S, Blackwell T, Ensrud KE, Cauley JA, Redline S, et al. Actigraphy-measured sleep characteristics and risk of falls in older women. Arch Intern Med. 2008;168(16):1768–75. Epub 2008/09/10.

    Article  PubMed  Google Scholar 

  16. Alamgir H, Muazzam S, Nasrullah M. Unintentional falls mortality among elderly in the United States: time for action. Injury. 2012;43(12):2065–71. Epub 2012/01/24.

    Article  PubMed  Google Scholar 

  17. Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep. 2004;27(7):1255–73. Epub 2004/12/14.

    PubMed  Google Scholar 

  18. Dijk DJ, Duffy JF, Czeisler CA. Age-related increase in awakenings: impaired consolidation of nonREM sleep at all circadian phases. Sleep. 2001;24(5):565–77. Epub 2001/08/02.

    PubMed  CAS  Google Scholar 

  19. Zepelin H, McDonald CS, Zammit GK. Effects of age on auditory awakening thresholds. J Gerontol. 1984;39(3):294–300. Epub 1984/05/01.

    Article  PubMed  CAS  Google Scholar 

  20. Foley DJ, Vitiello MV, Bliwise DL, Ancoli-Israel S, Monjan AA, Walsh JK. Frequent napping is associated with excessive daytime sleepiness, depression, pain, and nocturia in older adults: findings from the National Sleep Foundation '2003 Sleep in America' Poll. Am J Geriatr Psychiatry. 2007;15(4):344–50. Epub 2007/03/27.

    Article  PubMed  Google Scholar 

  21. Campbell SS, Murphy PJ, Stauble TN. Effects of a nap on nighttime sleep and waking function in older subjects. J Am Geriatr Soc. 2005;53(1):48–53. Epub 2005/01/26.

    Article  PubMed  Google Scholar 

  22. Monk TH, Buysse DJ, Carrier J, Billy BD, Rose LR. Effects of afternoon "siesta" naps on sleep, alertness, performance, and circadian rhythms in the elderly. Sleep. 2001;24(6):680–7. Epub 2001/09/19.

    PubMed  CAS  Google Scholar 

  23. Tamaki M, Shirota A, Tanaka H, Hayashi M, Hori T. Effects of a daytime nap in the aged. Psychiatry Clin Neurosci. 1999;53(2):273–5. Epub 1999/08/25.

    Article  PubMed  CAS  Google Scholar 

  24. Gammack JK. Light therapy for insomnia in older adults. Clin Geriatr Med. 2008;24(1):139–49. Viii, Epub 2007/11/24.

    Article  PubMed  Google Scholar 

  25. Kennaway DJ, Lushington K, Dawson D, Lack L, van den Heuvel C, Rogers N. Urinary 6-sulfatoxymelatonin excretion and aging: new results and a critical review of the literature. J Pineal Res. 1999;27(4):210–20. Epub 1999/11/07.

    Article  PubMed  CAS  Google Scholar 

  26. van Coevorden A, Mockel J, Laurent E, Kerkhofs M, L'Hermite-Baleriaux M, Decoster C, et al. Neuroendocrine rhythms and sleep in aging men. Am J Physiol. 1991;260(4 Pt 1):E651–61. Epub 1991/04/01.

    PubMed  Google Scholar 

  27. Pandi-Perumal SR, Zisapel N, Srinivasan V, Cardinali DP. Melatonin and sleep in aging population. Exp Gerontol. 2005;40(12):911–25. Epub 2005/09/27.

    Article  PubMed  CAS  Google Scholar 

  28. Crowley K. Sleep and sleep disorders in older adults. Neuropsychol Rev. 2011;21(1):41–53. Epub 2011/01/13.

    Article  PubMed  Google Scholar 

  29. Roepke SK, Ancoli-Israel S. Sleep disorders in the elderly. Indian J Med Res. 2010;131:302–10. Epub 2010/03/24.

    PubMed  Google Scholar 

  30. Ancoli-Israel S, Kripke DF, Klauber MR, Mason WJ, Fell R, Kaplan O. Sleep-disordered breathing in community-dwelling elderly. Sleep. 1991;14(6):486–95. Epub 1991/12/01.

    PubMed  CAS  PubMed Central  Google Scholar 

  31. Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, et al. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med. 2002;162(8):893–900. Epub 2002/04/23.

    Article  PubMed  Google Scholar 

  32. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328(17):1230–5. Epub 1993/04/29.

    Article  PubMed  CAS  Google Scholar 

  33. Newman AB, Foster G, Givelber R, Nieto FJ, Redline S, Young T. Progression and regression of sleep-disordered breathing with changes in weight: the Sleep Heart Health Study. Arch Intern Med. 2005;165(20):2408–13. Epub 2005/11/17.

    Article  PubMed  Google Scholar 

  34. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999–2000. JAMA. 2002;288(14):1723–7. Epub 2002/10/09.

    Article  PubMed  Google Scholar 

  35. Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005;365(9464):1046–53. Epub 2005/03/23.

    Article  PubMed  Google Scholar 

  36. Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med. 2005;172(11):1447–51. Epub 2005/09/06.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353(19):2034–41. Epub 2005/11/12.

    Article  PubMed  CAS  Google Scholar 

  38. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Nieto FJ, et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med. 2001;163(1):19–25. Epub 2001/02/24.

    Article  PubMed  CAS  Google Scholar 

  39. Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA. 2003;290(14):1906–14. Epub 2003/10/09.

    Article  PubMed  CAS  Google Scholar 

  40. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000;283(14):1829–36. Epub 2000/04/19.

    Article  PubMed  CAS  Google Scholar 

  41. Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378–84. Epub 2000/05/11.

    Article  PubMed  CAS  Google Scholar 

  42. Worsnop CJ, Naughton MT, Barter CE, Morgan TO, Anderson AI, Pierce RJ. The prevalence of obstructive sleep apnea in hypertensives. Am J Respir Crit Care Med. 1998;157(1):111–5. Epub 1998/01/28.

    Article  PubMed  CAS  Google Scholar 

  43. Quan SF, Wright R, Baldwin CM, Kaemingk KL, Goodwin JL, Kuo TF, et al. Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study. Sleep Med. 2006;7(6):498–507. Epub 2006/07/04.

    Article  PubMed  Google Scholar 

  44. Milligan SA, Chesson AL. Restless legs syndrome in the older adult: diagnosis and management. Drugs Aging. 2002;19(10):741–51. Epub 2002/10/23.

    Article  PubMed  CAS  Google Scholar 

  45. Phillips B, Young T, Finn L, Asher K, Hening WA, Purvis C. Epidemiology of restless legs symptoms in adults. Arch Intern Med. 2000;160(14):2137–41. Epub 2000/07/25.

    Article  PubMed  CAS  Google Scholar 

  46. Berger K, Luedemann J, Trenkwalder C, John U, Kessler C. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med. 2004;164(2):196–202. Epub 2004/01/28.

    Article  PubMed  Google Scholar 

  47. Ohayon MM, Roth T. Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J Psychosom Res. 2002;53(1):547–54. Epub 2002/07/20.

    Article  PubMed  Google Scholar 

  48. Hoque R, Chesson Jr AL. Pharmacologically induced/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis. J Clin Sleep Med. 2010;6(1):79–83. Epub 2010/03/03.

    PubMed  PubMed Central  Google Scholar 

  49. Birrer RB, Vemuri SP. Depression in later life: a diagnostic and therapeutic challenge. Am Fam Physician. 2004;69(10):2375–82. Epub 2004/06/01.

    PubMed  Google Scholar 

  50. Perlis ML, Smith LJ, Lyness JM, Matteson SR, Pigeon WR, Jungquist CR, et al. Insomnia as a risk factor for onset of depression in the elderly. Behav Sleep Med. 2006;4(2):104–13. Epub 2006/04/04.

    Article  PubMed  Google Scholar 

  51. Ancoli-Israel S, Ayalon L, Salzman C. Sleep in the elderly: normal variations and common sleep disorders. Harv Rev Psychiatry. 2008;16(5):279–86. Epub 2008/09/23.

    Article  PubMed  Google Scholar 

  52. Morin CM, Culbert JP, Schwartz SM. Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy. Am J Psychiatry. 1994;151(8):1172–80. Epub 1994/08/01.

    PubMed  CAS  Google Scholar 

  53. Murtagh DR, Greenwood KM. Identifying effective psychological treatments for insomnia: a meta-analysis. J Consult Clin Psychol. 1995;63(1):79–89. Epub 1995/02/01.

    Article  PubMed  CAS  Google Scholar 

  54. Engle-Friedman M, Bootzin RR, Hazlewood L, Tsao C. An evaluation of behavioral treatments for insomnia in the older adult. J Clin Psychol. 1992;48(1):77–90. Epub 1992/01/01.

    Article  PubMed  CAS  Google Scholar 

  55. Friedman L, Bliwise DL, Yesavage JA, Salom SR. A preliminary study comparing sleep restriction and relaxation treatments for insomnia in older adults. J Gerontol. 1991;46(1):1–8. Epub 1991/01/01.

    Article  Google Scholar 

  56. Lichstein KL, Johnson RS. Relaxation for insomnia and hypnotic medication use in older women. Psychol Aging. 1993;8(1):103–11. Epub 1993/03/01.

    Article  PubMed  CAS  Google Scholar 

  57. Morin CM, Azrin NH. Behavioral and cognitive treatments of geriatric insomnia. J Consult Clin Psychol. 1988;56(5):748–53. Epub 1988/10/01.

    Article  PubMed  CAS  Google Scholar 

  58. Morin CM, Kowatch RA, Barry T, Walton E. Cognitive-behavior therapy for late-life insomnia. J Consult Clin Psychol. 1993;61(1):137–46. Epub 1993/02/01.

    Article  PubMed  CAS  Google Scholar 

  59. Chesson Jr AL, Anderson WM, Littner M, Davila D, Hartse K, Johnson S, et al. Practice parameters for the nonpharmacologic treatment of chronic insomnia. An American Academy of Sleep Medicine report Standards of Practice Committee of the American Academy of Sleep Medicine. Sleep. 1999;22(8):1128–33. Epub 2000/01/05.

    PubMed  Google Scholar 

  60. Campbell SS, Dawson D, Anderson MW. Alleviation of sleep maintenance insomnia with timed exposure to bright light. J Am Geriatr Soc. 1993;41(8):829–36. Epub 1993/08/01.

    PubMed  CAS  Google Scholar 

  61. Murphy PJ, Campbell SS. Enhanced performance in elderly subjects following bright light treatment of sleep maintenance insomnia. J Sleep Res. 1996;5(3):165–72. Epub 1996/09/01.

    Article  PubMed  CAS  Google Scholar 

  62. Friedman L, Zeitzer JM, Kushida C, Zhdanova I, Noda A, Lee T, et al. Scheduled bright light for treatment of insomnia in older adults. J Am Geriatr Soc. 2009;57(3):441–52. Epub 2009/02/04.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Suhner AG, Murphy PJ, Campbell SS. Failure of timed bright light exposure to alleviate age-related sleep maintenance insomnia. J Am Geriatr Soc. 2002;50(4):617–23. Epub 2002/05/02.

    Article  PubMed  Google Scholar 

  64. Montgomery P, Dennis J. Bright light therapy for sleep problems in adults aged 60+. Cochrane Database Syst Rev. 2002;2, CD003403. Epub 2002/06/22.

    PubMed  Google Scholar 

  65. Yang PY, Ho KH, Chen HC, Chien MY. Exercise training improves sleep quality in middle-aged and older adults with sleep problems: a systematic review. J Physiother. 2012;58(3):157–63. Epub 2012/08/14.

    Article  PubMed  Google Scholar 

  66. King AC, Pruitt LA, Woo S, Castro CM, Ahn DK, Vitiello MV, et al. Effects of moderate-intensity exercise on polysomnographic and subjective sleep quality in older adults with mild to moderate sleep complaints. J Gerontol A Biol Sci Med Sci. 2008;63(9):997–1004. Epub 2008/10/09.

    Article  PubMed  Google Scholar 

  67. Alzheimer's Association. 2012 Alzheimer's disease facts and figures. Alzheimer Dementia. 2012;8(2):131–68.

    Article  Google Scholar 

  68. Wang C, Collet JP, Lau J. The effect of Tai Chi on health outcomes in patients with chronic conditions: a systematic review. Arch Intern Med. 2004;164(5):493–501. Epub 2004/03/10.

    Article  PubMed  Google Scholar 

  69. Li F, Fisher KJ, Harmer P, Irbe D, Tearse RG, Weimer C. Tai chi and self-rated quality of sleep and daytime sleepiness in older adults: a randomized controlled trial. J Am Geriatr Soc. 2004;52(6):892–900. Epub 2004/05/27.

    Article  PubMed  Google Scholar 

  70. Irwin MR, Olmstead R, Motivala SJ. Improving sleep quality in older adults with moderate sleep complaints: a randomized controlled trial of Tai Chi Chih. Sleep. 2008;31(7):1001–8. Epub 2008/07/26.

    PubMed  PubMed Central  Google Scholar 

  71. DHHS. Physical Activity Guidelines for Americans. Rockville, MD: U.S. Department of Health and Human Services; 2008. p. 2008.

    Google Scholar 

  72. Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 2005; 20(12):1151–8. Epub 2006/01/21.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Almeida Montes LG, Ontiveros Uribe MP, Cortes Sotres J, Heinze MG. Treatment of primary insomnia with melatonin: a double-blind, placebo-controlled, crossover study. J Psychiatry Neurosci. 2003;28(3):191–6. Epub 2003/06/07.

    PubMed  Google Scholar 

  74. American Geriatrics Society. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616–31.

    Article  Google Scholar 

  75. Drug Safety Communication FDA. FDA approves new label changes and dosing for zolpidem products and a recommendation to avoid driving the day after using Ambien CR. 2013. Available from: http://www.fda.gov/Drugs/DrugSafety/ucm352085.htm.

    Google Scholar 

  76. Ancoli-Israel S, Richardson GS, Mangano RM, Jenkins L, Hall P, Jones WS. Long-term use of sedative hypnotics in older patients with insomnia. Sleep Med. 2005;6(2):107–13. Epub 2005/02/18.

    Article  PubMed  Google Scholar 

  77. Roger M, Attali P, Coquelin JP. Multicenter, double-blind, controlled comparison of zolpidem and triazolam in elderly patients with insomnia. Clin Ther. 1993;15(1):127–36. Epub 1993/01/01.

    PubMed  CAS  Google Scholar 

  78. Roth T, Soubrane C, Titeux L, Walsh JK. Efficacy and safety of zolpidem-MR: a double-blind, placebo-controlled study in adults with primary insomnia. Sleep Med. 2006;7(5):397–406. Epub 2006/07/04.

    Article  PubMed  Google Scholar 

  79. Scharf M, Erman M, Rosenberg R, Seiden D, McCall WV, Amato D, et al. A 2-week efficacy and safety study of eszopiclone in elderly patients with primary insomnia. Sleep. 2005;28(6):720–7. Epub 2006/02/16.

    PubMed  Google Scholar 

  80. Dolder C, Nelson M, McKinsey J. Use of non-benzodiazepine hypnotics in the elderly: are all agents the same? CNS Drugs. 2007;21(5):389–405. Epub 2007/04/24.

    Article  PubMed  CAS  Google Scholar 

  81. Information P. SILENOR(R) oral tablets, doxepin oral tablets. San Diego, CA: Somaxon Pharmaceuticals, Inc.; 2010.

    Google Scholar 

  82. Roth T, Seiden D, Sainati S, Wang-Weigand S, Zhang J, Zee P. Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia. Sleep Med. 2006;7(4):312–8. Epub 2006/05/20.

    Article  PubMed  Google Scholar 

  83. Roth T, Seiden D, Wang-Weigand S, Zhang J. A 2-night, 3-period, crossover study of ramelteon's efficacy and safety in older adults with chronic insomnia. Curr Med Res Opin. 2007;23(5):1005–14. Epub 2007/05/24.

    Article  PubMed  CAS  Google Scholar 

  84. Liu J, Wang LN. Ramelteon in the treatment of chronic insomnia: systematic review and meta-analysis. Int J Clin Pract. 2012;66(9):867–73. Epub 2012/08/18.

    Article  PubMed  CAS  Google Scholar 

  85. Information P. ROZEREM(R) oral tablets, ramelteon oral tablets. Takeda Pharmaceutical Company: Lincolnshire, IL; 2008.

    Google Scholar 

  86. Thies W, Bleiler L. 2013 Alzheimer's disease facts and figures. Alzheimer Dementia. 2013;9(2):208–45. Epub 2013/03/20.

    Article  Google Scholar 

  87. Gaugler JE, Edwards AB, Femia EE, Zarit SH, Stephens MA, Townsend A, et al. Predictors of institutionalization of cognitively impaired elders: family help and the timing of placement. J Gerontol B Psychol Sci Soc Sci. 2000;55(4):P247–55. Epub 2001/10/05.

    Article  PubMed  CAS  Google Scholar 

  88. Pollak CP, Perlick D. Sleep problems and institutionalization of the elderly. J Geriatr Psychiatry Neurol. 1991;4(4):204–10. Epub 1991/10/01.

    Article  PubMed  CAS  Google Scholar 

  89. Roth HL. Dementia and sleep. Neurol Clin. 2012;30(4):1213–48. Epub 2012/10/27.

    Article  PubMed  Google Scholar 

  90. Stopa EG, Volicer L, Kuo-Leblanc V, Harper D, Lathi D, Tate B, et al. Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia. J Neuropathol Exp Neurol. 1999;58(1):29–39. Epub 1999/02/12.

    Article  PubMed  CAS  Google Scholar 

  91. Onen F, Onen SH. [Sleep rhythm disturbances in Alzheimer's disease]. La Revue de medecine interne / fondee par la Societe nationale francaise de medecine interne. 2003;24(3):165–71. Epub 2003/03/27. Alterations des rythmes du sommeil dans la maladie d'Alzheimer.

    Google Scholar 

  92. Ayalon L, Ancoli-Israel S, Stepnowsky C, Marler M, Palmer BW, Liu L, et al. Adherence to continuous positive airway pressure treatment in patients with Alzheimer's disease and obstructive sleep apnea. Am J Geriatr Psychiatry. 2006;14(2):176–80. Epub 2006/02/14.

    Article  PubMed  Google Scholar 

  93. Ancoli-Israel S, Palmer BW, Cooke JR, Corey-Bloom J, Fiorentino L, Natarajan L, et al. Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study. J Am Geriatr Soc. 2008;56(11):2076–81. Epub 2008/09/18.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Martinez-Garcia MA, Galiano-Blancart R, Roman-Sanchez P, Soler-Cataluna JJ, Cabero-Salt L, Salcedo-Maiques E. Continuous positive airway pressure treatment in sleep apnea prevents new vascular events after ischemic stroke. Chest. 2005;128(4):2123–9. Epub 2005/10/21.

    Article  PubMed  Google Scholar 

  95. Information P. RAZADYNE (R) ER extended release oral capsules, oral tablets, oral solution, galantamine hBr capsules, oral tablets, oral solution. Titusville, NJ: Ortho-McNeil Neurologics, Inc.; 2007.

    Google Scholar 

  96. Information P. ARICEPT (R) oral tablets, donepezil hydrochloride oral tablets. New York, NY: Eisai Co. Ltd.; 2010.

    Google Scholar 

  97. Information P. EXELON (R) PATCH, transdermal patch, rivastigmine transdermal patch. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2013.

    Google Scholar 

  98. Nieoullon A, Bentue-Ferrer D, Bordet R, Tsolaki M, Forstl H. Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: focus on galantamine*. Curr Med Res Opin. 2008;24(12):3357–67. Epub 2008/11/27.

    Article  PubMed  CAS  Google Scholar 

  99. Information P. NAMENDA (R) oral tablets, solution, memantine hydrochloride oral tablets, solution. St. Louis, MO: Forest Pharmaceuticals, Inc.; 2007.

    Google Scholar 

  100. McCurry SM, Gibbons LE, Logsdon RG, Vitiello M, Teri L. Training caregivers to change the sleep hygiene practices of patients with dementia: the NITE-AD project. J Am Geriatr Soc. 2003;51(10):1455–60. Epub 2003/09/27.

    Article  PubMed  Google Scholar 

  101. McCurry SM, Gibbons LE, Logsdon RG, Vitiello MV, Teri L. Nighttime insomnia treatment and education for Alzheimer's disease: a randomized, controlled trial. J Am Geriatr Soc. 2005;53(5):793–802. Epub 2005/05/10.

    Article  PubMed  Google Scholar 

  102. Forbes D, Culum I, Lischka AR, Morgan DG, Peacock S, Forbes J, et al. Light therapy for managing cognitive, sleep, functional, behavioural, or psychiatric disturbances in dementia. Cochrane Database Syst Rev. 2009;4, CD003946. Epub 2009/10/13.

    PubMed  Google Scholar 

  103. Gehrman PR, Connor DJ, Martin JL, Shochat T, Corey-Bloom J, Ancoli-Israel S. Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. Am J Geriatr Psychiatry. 2009;17(2):166–9. Epub 2009/01/22.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Serfaty M, Kennell-Webb S, Warner J, Blizard R, Raven P. Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr Psychiatry. 2002;17(12):1120–7. Epub 2002/12/04.

    Article  PubMed  Google Scholar 

  105. Singer C, Tractenberg RE, Kaye J, Schafer K, Gamst A, Grundman M, et al. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep. 2003;26(7):893–901. Epub 2003/12/06.

    PubMed  Google Scholar 

  106. Dowling GA, Burr RL, Van Someren EJ, Hubbard EM, Luxenberg JS, Mastick J, et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. J Am Geriatr Soc. 2008;56(2):239–46. Epub 2007/12/12.

    Article  PubMed  PubMed Central  Google Scholar 

  107. Harrington JJ, Lee-Chiong Jr T. Sleep and older patients. Clin Chest Med. 2007;28(4):673–84. v. Epub 2007/10/31.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kerry L. Hildreth M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Hildreth, K.L., Linnebur, S.A., Parnes, B. (2014). Sleep in the Elderly. In: Pagel, J., Pandi-Perumal, S. (eds) Primary Care Sleep Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1185-1_28

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-1185-1_28

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1184-4

  • Online ISBN: 978-1-4939-1185-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics