Abstract
Sleep complaints are highly prevalent in older adults, and typically present to the primary care clinician. They are associated with potentially catastrophic consequences, such as injuries from falls and motor vehicle accidents. Typical changes in sleep associated with age include delayed sleep onset, frequent awakenings, and a phase shift to earlier sleep and earlier awakening. Some primary sleep disorders are more common in older adults, such as restless legs syndrome and sleep-disordered breathing. In most cases, the cause of sleep complaints is multifactorial, involving primary sleep disorders, comorbid medical and psychiatric illnesses, and the effects of medications and polypharmacy. Whenever possible, treatment of insomnia in older adults should include treatment of contributing factors, adjustment of current medications, and non-pharmacologic measures, such as exercise. Medications to treat insomnia should be selected and used judiciously, utilizing the lowest effective doses. The evaluation and treatment of sleep disturbances requires special considerations in the growing population of individuals with dementia. When sleep complaints are successfully addressed, there is often an increase in quality of life, both for the patient and family members/caregivers.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsAbbreviations
- AD:
-
Alzheimer’s disease
- BLT:
-
Bright light therapy
- CBT:
-
Cognitive behavioral therapy
- EEG:
-
Electroencephalography
- EPESE:
-
Established populations for epidemiologic studies of the elderly
- HEDIS:
-
Health plan employer data information set
- LBD:
-
Lewy body dementia
- OTC:
-
Over the counter
- PDD:
-
Parkinson’s disease dementia
- PLMS:
-
Periodic limb movements of sleep
- PSQI:
-
Pittsburgh sleep quality index
- RBD:
-
REM sleep behavior disorder
- REM:
-
Rapid eye movement
- RLS:
-
Restless legs syndrome
- SDB:
-
Sleep disordered breathing
References
U.S. Census Bureau. 2010 Census briefs: the older population: 2010. C2010BR-09. November, 2011. Report no.: Contract no.: C2010BR-09.
U.S. Census Bureau. The next four decades. The older population in the United States: 2010 to 2050. Population Estimates and Projections. pp 25–1138
Colwill JM, Cultice JM, Kruse RL. Will generalist physician supply meet demands of an increasing and aging population? Health Aff (Millwood). 2008;27(3):w232–41. Epub 2008/05/01.
Monjan AA. Sleep in Aging. In: Pandi-Perumal DLSR, editor. Sleep disorders: their impact on public health. Abingdon: Informa Healthcare; 2007. p. 59–65.
Foley DJ, Monjan AA, Brown SL, Simonsick EM, Wallace RB, Blazer DG. Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep. 1995;18(6):425–32. Epub 1995/07/01.
Foley DJ, Monjan A, Simonsick EM, Wallace RB, Blazer DG. Incidence and remission of insomnia among elderly adults: an epidemiologic study of 6,800 persons over three years. Sleep. 1999;22 Suppl 2:S366–72. Epub 1999/07/08.
Blackwell T, Yaffe K, Ancoli-Israel S, Schneider JL, Cauley JA, Hillier TA, et al. Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci. 2006;61(4):405–10. Epub 2006/04/14.
Roth T, Ancoli-Israel S. Daytime consequences and correlates of insomnia in the United States: results of the 1991 National Sleep Foundation Survey. II. Sleep. 1999;22 Suppl 2:S354–8. Epub 1999/07/08.
Dam TT, Ewing S, Ancoli-Israel S, Ensrud K, Redline S, Stone K. Association between sleep and physical function in older men: the osteoporotic fractures in men sleep study. J Am Geriatr Soc. 2008;56(9):1665–73. Epub 2008/09/02.
Ford DE, Kamerow DB. Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? J Am Med Assoc. 1989;262(11):1479–84.
Dew MA, Hoch CC, Buysse DJ, Monk TH, Begley AE, Houck PR, et al. Healthy older adults' sleep predicts all-cause mortality at 4 to 19 years of follow-up. Psychosom Med. 2003;65(1):63–73. Epub 2003/01/30.
Newman AB, Spiekerman CF, Enright P, Lefkowitz D, Manolio T, Reynolds CF, et al. Daytime sleepiness predicts mortality and cardiovascular disease in older adults. The Cardiovascular Health Study Research Group. J Am Geriatr Soc. 2000;48(2):115–23. Epub 2000/02/22.
Robillard R, Prince F, Filipini D, Carrier J. Aging worsens the effects of sleep deprivation on postural control. PLoS One. 2011;6(12):e28731. Epub 2011/12/14.
Brassington GS, King AC, Bliwise DL. Sleep problems as a risk factor for falls in a sample of community-dwelling adults aged 64–99 years. J Am Geriatr Soc. 2000;48(10):1234–40. Epub 2000/10/19.
Stone KL, Ancoli-Israel S, Blackwell T, Ensrud KE, Cauley JA, Redline S, et al. Actigraphy-measured sleep characteristics and risk of falls in older women. Arch Intern Med. 2008;168(16):1768–75. Epub 2008/09/10.
Alamgir H, Muazzam S, Nasrullah M. Unintentional falls mortality among elderly in the United States: time for action. Injury. 2012;43(12):2065–71. Epub 2012/01/24.
Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep. 2004;27(7):1255–73. Epub 2004/12/14.
Dijk DJ, Duffy JF, Czeisler CA. Age-related increase in awakenings: impaired consolidation of nonREM sleep at all circadian phases. Sleep. 2001;24(5):565–77. Epub 2001/08/02.
Zepelin H, McDonald CS, Zammit GK. Effects of age on auditory awakening thresholds. J Gerontol. 1984;39(3):294–300. Epub 1984/05/01.
Foley DJ, Vitiello MV, Bliwise DL, Ancoli-Israel S, Monjan AA, Walsh JK. Frequent napping is associated with excessive daytime sleepiness, depression, pain, and nocturia in older adults: findings from the National Sleep Foundation '2003 Sleep in America' Poll. Am J Geriatr Psychiatry. 2007;15(4):344–50. Epub 2007/03/27.
Campbell SS, Murphy PJ, Stauble TN. Effects of a nap on nighttime sleep and waking function in older subjects. J Am Geriatr Soc. 2005;53(1):48–53. Epub 2005/01/26.
Monk TH, Buysse DJ, Carrier J, Billy BD, Rose LR. Effects of afternoon "siesta" naps on sleep, alertness, performance, and circadian rhythms in the elderly. Sleep. 2001;24(6):680–7. Epub 2001/09/19.
Tamaki M, Shirota A, Tanaka H, Hayashi M, Hori T. Effects of a daytime nap in the aged. Psychiatry Clin Neurosci. 1999;53(2):273–5. Epub 1999/08/25.
Gammack JK. Light therapy for insomnia in older adults. Clin Geriatr Med. 2008;24(1):139–49. Viii, Epub 2007/11/24.
Kennaway DJ, Lushington K, Dawson D, Lack L, van den Heuvel C, Rogers N. Urinary 6-sulfatoxymelatonin excretion and aging: new results and a critical review of the literature. J Pineal Res. 1999;27(4):210–20. Epub 1999/11/07.
van Coevorden A, Mockel J, Laurent E, Kerkhofs M, L'Hermite-Baleriaux M, Decoster C, et al. Neuroendocrine rhythms and sleep in aging men. Am J Physiol. 1991;260(4 Pt 1):E651–61. Epub 1991/04/01.
Pandi-Perumal SR, Zisapel N, Srinivasan V, Cardinali DP. Melatonin and sleep in aging population. Exp Gerontol. 2005;40(12):911–25. Epub 2005/09/27.
Crowley K. Sleep and sleep disorders in older adults. Neuropsychol Rev. 2011;21(1):41–53. Epub 2011/01/13.
Roepke SK, Ancoli-Israel S. Sleep disorders in the elderly. Indian J Med Res. 2010;131:302–10. Epub 2010/03/24.
Ancoli-Israel S, Kripke DF, Klauber MR, Mason WJ, Fell R, Kaplan O. Sleep-disordered breathing in community-dwelling elderly. Sleep. 1991;14(6):486–95. Epub 1991/12/01.
Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, et al. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med. 2002;162(8):893–900. Epub 2002/04/23.
Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328(17):1230–5. Epub 1993/04/29.
Newman AB, Foster G, Givelber R, Nieto FJ, Redline S, Young T. Progression and regression of sleep-disordered breathing with changes in weight: the Sleep Heart Health Study. Arch Intern Med. 2005;165(20):2408–13. Epub 2005/11/17.
Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999–2000. JAMA. 2002;288(14):1723–7. Epub 2002/10/09.
Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005;365(9464):1046–53. Epub 2005/03/23.
Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med. 2005;172(11):1447–51. Epub 2005/09/06.
Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353(19):2034–41. Epub 2005/11/12.
Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Nieto FJ, et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med. 2001;163(1):19–25. Epub 2001/02/24.
Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA. 2003;290(14):1906–14. Epub 2003/10/09.
Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000;283(14):1829–36. Epub 2000/04/19.
Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378–84. Epub 2000/05/11.
Worsnop CJ, Naughton MT, Barter CE, Morgan TO, Anderson AI, Pierce RJ. The prevalence of obstructive sleep apnea in hypertensives. Am J Respir Crit Care Med. 1998;157(1):111–5. Epub 1998/01/28.
Quan SF, Wright R, Baldwin CM, Kaemingk KL, Goodwin JL, Kuo TF, et al. Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study. Sleep Med. 2006;7(6):498–507. Epub 2006/07/04.
Milligan SA, Chesson AL. Restless legs syndrome in the older adult: diagnosis and management. Drugs Aging. 2002;19(10):741–51. Epub 2002/10/23.
Phillips B, Young T, Finn L, Asher K, Hening WA, Purvis C. Epidemiology of restless legs symptoms in adults. Arch Intern Med. 2000;160(14):2137–41. Epub 2000/07/25.
Berger K, Luedemann J, Trenkwalder C, John U, Kessler C. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med. 2004;164(2):196–202. Epub 2004/01/28.
Ohayon MM, Roth T. Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J Psychosom Res. 2002;53(1):547–54. Epub 2002/07/20.
Hoque R, Chesson Jr AL. Pharmacologically induced/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis. J Clin Sleep Med. 2010;6(1):79–83. Epub 2010/03/03.
Birrer RB, Vemuri SP. Depression in later life: a diagnostic and therapeutic challenge. Am Fam Physician. 2004;69(10):2375–82. Epub 2004/06/01.
Perlis ML, Smith LJ, Lyness JM, Matteson SR, Pigeon WR, Jungquist CR, et al. Insomnia as a risk factor for onset of depression in the elderly. Behav Sleep Med. 2006;4(2):104–13. Epub 2006/04/04.
Ancoli-Israel S, Ayalon L, Salzman C. Sleep in the elderly: normal variations and common sleep disorders. Harv Rev Psychiatry. 2008;16(5):279–86. Epub 2008/09/23.
Morin CM, Culbert JP, Schwartz SM. Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy. Am J Psychiatry. 1994;151(8):1172–80. Epub 1994/08/01.
Murtagh DR, Greenwood KM. Identifying effective psychological treatments for insomnia: a meta-analysis. J Consult Clin Psychol. 1995;63(1):79–89. Epub 1995/02/01.
Engle-Friedman M, Bootzin RR, Hazlewood L, Tsao C. An evaluation of behavioral treatments for insomnia in the older adult. J Clin Psychol. 1992;48(1):77–90. Epub 1992/01/01.
Friedman L, Bliwise DL, Yesavage JA, Salom SR. A preliminary study comparing sleep restriction and relaxation treatments for insomnia in older adults. J Gerontol. 1991;46(1):1–8. Epub 1991/01/01.
Lichstein KL, Johnson RS. Relaxation for insomnia and hypnotic medication use in older women. Psychol Aging. 1993;8(1):103–11. Epub 1993/03/01.
Morin CM, Azrin NH. Behavioral and cognitive treatments of geriatric insomnia. J Consult Clin Psychol. 1988;56(5):748–53. Epub 1988/10/01.
Morin CM, Kowatch RA, Barry T, Walton E. Cognitive-behavior therapy for late-life insomnia. J Consult Clin Psychol. 1993;61(1):137–46. Epub 1993/02/01.
Chesson Jr AL, Anderson WM, Littner M, Davila D, Hartse K, Johnson S, et al. Practice parameters for the nonpharmacologic treatment of chronic insomnia. An American Academy of Sleep Medicine report Standards of Practice Committee of the American Academy of Sleep Medicine. Sleep. 1999;22(8):1128–33. Epub 2000/01/05.
Campbell SS, Dawson D, Anderson MW. Alleviation of sleep maintenance insomnia with timed exposure to bright light. J Am Geriatr Soc. 1993;41(8):829–36. Epub 1993/08/01.
Murphy PJ, Campbell SS. Enhanced performance in elderly subjects following bright light treatment of sleep maintenance insomnia. J Sleep Res. 1996;5(3):165–72. Epub 1996/09/01.
Friedman L, Zeitzer JM, Kushida C, Zhdanova I, Noda A, Lee T, et al. Scheduled bright light for treatment of insomnia in older adults. J Am Geriatr Soc. 2009;57(3):441–52. Epub 2009/02/04.
Suhner AG, Murphy PJ, Campbell SS. Failure of timed bright light exposure to alleviate age-related sleep maintenance insomnia. J Am Geriatr Soc. 2002;50(4):617–23. Epub 2002/05/02.
Montgomery P, Dennis J. Bright light therapy for sleep problems in adults aged 60+. Cochrane Database Syst Rev. 2002;2, CD003403. Epub 2002/06/22.
Yang PY, Ho KH, Chen HC, Chien MY. Exercise training improves sleep quality in middle-aged and older adults with sleep problems: a systematic review. J Physiother. 2012;58(3):157–63. Epub 2012/08/14.
King AC, Pruitt LA, Woo S, Castro CM, Ahn DK, Vitiello MV, et al. Effects of moderate-intensity exercise on polysomnographic and subjective sleep quality in older adults with mild to moderate sleep complaints. J Gerontol A Biol Sci Med Sci. 2008;63(9):997–1004. Epub 2008/10/09.
Alzheimer's Association. 2012 Alzheimer's disease facts and figures. Alzheimer Dementia. 2012;8(2):131–68.
Wang C, Collet JP, Lau J. The effect of Tai Chi on health outcomes in patients with chronic conditions: a systematic review. Arch Intern Med. 2004;164(5):493–501. Epub 2004/03/10.
Li F, Fisher KJ, Harmer P, Irbe D, Tearse RG, Weimer C. Tai chi and self-rated quality of sleep and daytime sleepiness in older adults: a randomized controlled trial. J Am Geriatr Soc. 2004;52(6):892–900. Epub 2004/05/27.
Irwin MR, Olmstead R, Motivala SJ. Improving sleep quality in older adults with moderate sleep complaints: a randomized controlled trial of Tai Chi Chih. Sleep. 2008;31(7):1001–8. Epub 2008/07/26.
DHHS. Physical Activity Guidelines for Americans. Rockville, MD: U.S. Department of Health and Human Services; 2008. p. 2008.
Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 2005; 20(12):1151–8. Epub 2006/01/21.
Almeida Montes LG, Ontiveros Uribe MP, Cortes Sotres J, Heinze MG. Treatment of primary insomnia with melatonin: a double-blind, placebo-controlled, crossover study. J Psychiatry Neurosci. 2003;28(3):191–6. Epub 2003/06/07.
American Geriatrics Society. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616–31.
Drug Safety Communication FDA. FDA approves new label changes and dosing for zolpidem products and a recommendation to avoid driving the day after using Ambien CR. 2013. Available from: http://www.fda.gov/Drugs/DrugSafety/ucm352085.htm.
Ancoli-Israel S, Richardson GS, Mangano RM, Jenkins L, Hall P, Jones WS. Long-term use of sedative hypnotics in older patients with insomnia. Sleep Med. 2005;6(2):107–13. Epub 2005/02/18.
Roger M, Attali P, Coquelin JP. Multicenter, double-blind, controlled comparison of zolpidem and triazolam in elderly patients with insomnia. Clin Ther. 1993;15(1):127–36. Epub 1993/01/01.
Roth T, Soubrane C, Titeux L, Walsh JK. Efficacy and safety of zolpidem-MR: a double-blind, placebo-controlled study in adults with primary insomnia. Sleep Med. 2006;7(5):397–406. Epub 2006/07/04.
Scharf M, Erman M, Rosenberg R, Seiden D, McCall WV, Amato D, et al. A 2-week efficacy and safety study of eszopiclone in elderly patients with primary insomnia. Sleep. 2005;28(6):720–7. Epub 2006/02/16.
Dolder C, Nelson M, McKinsey J. Use of non-benzodiazepine hypnotics in the elderly: are all agents the same? CNS Drugs. 2007;21(5):389–405. Epub 2007/04/24.
Information P. SILENOR(R) oral tablets, doxepin oral tablets. San Diego, CA: Somaxon Pharmaceuticals, Inc.; 2010.
Roth T, Seiden D, Sainati S, Wang-Weigand S, Zhang J, Zee P. Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia. Sleep Med. 2006;7(4):312–8. Epub 2006/05/20.
Roth T, Seiden D, Wang-Weigand S, Zhang J. A 2-night, 3-period, crossover study of ramelteon's efficacy and safety in older adults with chronic insomnia. Curr Med Res Opin. 2007;23(5):1005–14. Epub 2007/05/24.
Liu J, Wang LN. Ramelteon in the treatment of chronic insomnia: systematic review and meta-analysis. Int J Clin Pract. 2012;66(9):867–73. Epub 2012/08/18.
Information P. ROZEREM(R) oral tablets, ramelteon oral tablets. Takeda Pharmaceutical Company: Lincolnshire, IL; 2008.
Thies W, Bleiler L. 2013 Alzheimer's disease facts and figures. Alzheimer Dementia. 2013;9(2):208–45. Epub 2013/03/20.
Gaugler JE, Edwards AB, Femia EE, Zarit SH, Stephens MA, Townsend A, et al. Predictors of institutionalization of cognitively impaired elders: family help and the timing of placement. J Gerontol B Psychol Sci Soc Sci. 2000;55(4):P247–55. Epub 2001/10/05.
Pollak CP, Perlick D. Sleep problems and institutionalization of the elderly. J Geriatr Psychiatry Neurol. 1991;4(4):204–10. Epub 1991/10/01.
Roth HL. Dementia and sleep. Neurol Clin. 2012;30(4):1213–48. Epub 2012/10/27.
Stopa EG, Volicer L, Kuo-Leblanc V, Harper D, Lathi D, Tate B, et al. Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia. J Neuropathol Exp Neurol. 1999;58(1):29–39. Epub 1999/02/12.
Onen F, Onen SH. [Sleep rhythm disturbances in Alzheimer's disease]. La Revue de medecine interne / fondee par la Societe nationale francaise de medecine interne. 2003;24(3):165–71. Epub 2003/03/27. Alterations des rythmes du sommeil dans la maladie d'Alzheimer.
Ayalon L, Ancoli-Israel S, Stepnowsky C, Marler M, Palmer BW, Liu L, et al. Adherence to continuous positive airway pressure treatment in patients with Alzheimer's disease and obstructive sleep apnea. Am J Geriatr Psychiatry. 2006;14(2):176–80. Epub 2006/02/14.
Ancoli-Israel S, Palmer BW, Cooke JR, Corey-Bloom J, Fiorentino L, Natarajan L, et al. Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study. J Am Geriatr Soc. 2008;56(11):2076–81. Epub 2008/09/18.
Martinez-Garcia MA, Galiano-Blancart R, Roman-Sanchez P, Soler-Cataluna JJ, Cabero-Salt L, Salcedo-Maiques E. Continuous positive airway pressure treatment in sleep apnea prevents new vascular events after ischemic stroke. Chest. 2005;128(4):2123–9. Epub 2005/10/21.
Information P. RAZADYNE (R) ER extended release oral capsules, oral tablets, oral solution, galantamine hBr capsules, oral tablets, oral solution. Titusville, NJ: Ortho-McNeil Neurologics, Inc.; 2007.
Information P. ARICEPT (R) oral tablets, donepezil hydrochloride oral tablets. New York, NY: Eisai Co. Ltd.; 2010.
Information P. EXELON (R) PATCH, transdermal patch, rivastigmine transdermal patch. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2013.
Nieoullon A, Bentue-Ferrer D, Bordet R, Tsolaki M, Forstl H. Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: focus on galantamine*. Curr Med Res Opin. 2008;24(12):3357–67. Epub 2008/11/27.
Information P. NAMENDA (R) oral tablets, solution, memantine hydrochloride oral tablets, solution. St. Louis, MO: Forest Pharmaceuticals, Inc.; 2007.
McCurry SM, Gibbons LE, Logsdon RG, Vitiello M, Teri L. Training caregivers to change the sleep hygiene practices of patients with dementia: the NITE-AD project. J Am Geriatr Soc. 2003;51(10):1455–60. Epub 2003/09/27.
McCurry SM, Gibbons LE, Logsdon RG, Vitiello MV, Teri L. Nighttime insomnia treatment and education for Alzheimer's disease: a randomized, controlled trial. J Am Geriatr Soc. 2005;53(5):793–802. Epub 2005/05/10.
Forbes D, Culum I, Lischka AR, Morgan DG, Peacock S, Forbes J, et al. Light therapy for managing cognitive, sleep, functional, behavioural, or psychiatric disturbances in dementia. Cochrane Database Syst Rev. 2009;4, CD003946. Epub 2009/10/13.
Gehrman PR, Connor DJ, Martin JL, Shochat T, Corey-Bloom J, Ancoli-Israel S. Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. Am J Geriatr Psychiatry. 2009;17(2):166–9. Epub 2009/01/22.
Serfaty M, Kennell-Webb S, Warner J, Blizard R, Raven P. Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr Psychiatry. 2002;17(12):1120–7. Epub 2002/12/04.
Singer C, Tractenberg RE, Kaye J, Schafer K, Gamst A, Grundman M, et al. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep. 2003;26(7):893–901. Epub 2003/12/06.
Dowling GA, Burr RL, Van Someren EJ, Hubbard EM, Luxenberg JS, Mastick J, et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. J Am Geriatr Soc. 2008;56(2):239–46. Epub 2007/12/12.
Harrington JJ, Lee-Chiong Jr T. Sleep and older patients. Clin Chest Med. 2007;28(4):673–84. v. Epub 2007/10/31.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hildreth, K.L., Linnebur, S.A., Parnes, B. (2014). Sleep in the Elderly. In: Pagel, J., Pandi-Perumal, S. (eds) Primary Care Sleep Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1185-1_28
Download citation
DOI: https://doi.org/10.1007/978-1-4939-1185-1_28
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-1184-4
Online ISBN: 978-1-4939-1185-1
eBook Packages: MedicineMedicine (R0)