Skip to main content

Introduction—Castration Resistant Prostate Cancer: A Rapidly Expanding Clinical State and a Model for New Therapeutic Opportunities

  • Chapter
  • First Online:
Management of Castration Resistant Prostate Cancer

Part of the book series: Current Clinical Urology ((CCU))

  • 893 Accesses

Abstract

There has been a rather impressive growth in the systemic therapeutic options for prostate cancer in a relatively short period of time. In addition, knowledge in the basic biology of prostate cancer growth appears to have reached a significant threshold where translational approaches are more likely to result in significant clinically meaningful advances. This book describes the recent developments in castration resistant disease in laboratory and clinical research. New potential treatments and the rationale behind their selection for testing as well methodological challenges involved are described and discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cooperberg MR, Lubeck DP, Meng MV, et al. The changing face of low-risk prostate cancer: trends in clinical presentation and primary management. J Clin Oncol. 2004;22:2141–9.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Loblaw DA, Virgo KS, Nam R, et al. Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline. J Clin Oncol. 2007;25:1596–605.

    Article  CAS  PubMed  Google Scholar 

  3. Scher HI, Heller G. Clinical states in prostate cancer: towards a dynamic model of disease progression. Urology. 2000;55:323–7.

    Article  CAS  PubMed  Google Scholar 

  4. Makarov DV, Humphreys EB, Mangold LA, et al. The natural history of men treated with deferred androgen deprivation therapy in whom metastatic prostate cancer developed following radical prostatectomy. J Urol. 2008;179:156–61.

    Article  PubMed  Google Scholar 

  5. Smith MR, Saad F, Oudard S, Shore N, Fizazi K, Sieber P, Tombal B, Damiao R, Marx G, Miller K, van Veldhuizen P, Morote J, Ye Z, Dansey R, Goessi C. Denosumab and bone metastasis-Free survival in men with nonmetastatic castration resistant prostate cancer: exploratory analyses by baseline prostate specific antigen doubling time. J Clin Oncol. 2013;31:3800–6.

    Article  PubMed  Google Scholar 

  6. Tangen CM, Hussain MA, Higano CS, Eisenberger MA, Small EJ, Wilding G, Donnelly BJ, Shelhammer PF, Crawford ED, Vogelzang NJ, Powell IJ, Thompson IM. Improved survival trends of men with newly diagnosed M1 prostate cancer; A SWOG phase III trial experience (S8494, S8894 and S9346). J Urol. 2012;188:1164–9.

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mario A. Eisenberger MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Eisenberger, M.A., Saad, F. (2014). Introduction—Castration Resistant Prostate Cancer: A Rapidly Expanding Clinical State and a Model for New Therapeutic Opportunities. In: Saad, F., Eisenberger, M. (eds) Management of Castration Resistant Prostate Cancer. Current Clinical Urology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1176-9_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-1176-9_1

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1175-2

  • Online ISBN: 978-1-4939-1176-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics