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Nicotinic Receptors pp 137–167Cite as

Presynaptic Nicotinic Acetylcholine Receptors and the Modulation of Circuit Excitability

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Part of the book series: The Receptors ((REC,volume 26))

Abstract

Cholinergic modulation of circuit excitability by activation of nicotinic acetylcholine receptors (nAChRs) is involved in essential aspects of motivated behaviors, attention, and affect. In this review we focus entirely on the contribution of presynaptic nAChRs to the regulation and dysregulation of synapses and circuits in the CNS. In particular we highlight recent insights into the regulation of presynaptic nAChR targeting and advances into discerning the mechanisms by which presynaptic nAChRs regulate neurotransmitter release and synaptic transmission in the brain.

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Authors and Affiliations

  1. Department of Neurobiology and Behavior, Center for Brain and Spinal Cord Research, Stony Brook University, 100 Nicolls Road, Stony Brook, NY, 11794, USA

    Chongbo Zhong M.D. Ph.D., Gretchen Y. López-Hernández Ph.D., David A. Talmage Ph.D. & Lorna W. Role Ph.D.

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  1. Chongbo Zhong M.D. Ph.D.
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  2. Gretchen Y. López-Hernández Ph.D.
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  3. David A. Talmage Ph.D.
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Correspondence to Chongbo Zhong M.D. Ph.D. .

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  1. Department of Neurobiology SHEL 1006, University of Alabama at Birmingham, Birmingham, Alabama, USA

    Robin A.J. Lester

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Zhong, C., López-Hernández, G.Y., Talmage, D.A., Role, L.W. (2014). Presynaptic Nicotinic Acetylcholine Receptors and the Modulation of Circuit Excitability. In: Lester, R. (eds) Nicotinic Receptors. The Receptors, vol 26. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1167-7_7

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