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Operative Management of Metastatic Breast Cancer

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Abstract

Worldwide, breast cancer is the second most common malignancy in women. The World Health Organization estimated 3.78 million new cases of breast cancer in 2008 (GLOBOCAN 2008), with an associated 458,000 deaths from the disease during the same time period. The worldwide incidence of breast cancer is increasing as life expectancy lengthens and as non-western societies adopt the lifestyle practices of western society. In the United States, the American Cancer Society estimates 234,580 new breast cancers will be diagnosed and 40,030 deaths will occur in 2013. For women, a new diagnosis of breast cancer in 2013 will represent 29 % of all malignancies diagnosed. Despite the increase in incidence, breast cancer-related mortality has shown a steady decline over the last decade. The decline in mortality can primarily be attributed to two factors: the first is a better understanding of and adherence to screening guidelines, and the second is the advances made in the systemic treatment of breast cancer patients.

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References

  1. GLOBOCAN. Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012.

    Google Scholar 

  2. World Health Organization. Breast cancer: prevention and control. http://www.who.int. Accessed 21 Dec 2012.

  3. Siegel R, Naishadham D, Jemal A. SEER stat fact sheets: breast cancer. Cancer statistics, 2013. CA: Cancer J Clin. 2013;63:11–30.

    Google Scholar 

  4. American Cancer Society. Cancer facts and figures, 2012. http://www.cancer.org. Accessed 21 Dec 2012.

  5. National Cancer Institute. SEER Stat Fact Sheets: Breast Cancer. www.cancer.gov. Accessed 21 Dec 2012.

  6. Flanigan RC, Salmon SE, Blumenstein BA, et al. Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2wb alone for metastatic renal-cell cancer. NEJM. 2001;345:1655–9.

    Article  CAS  PubMed  Google Scholar 

  7. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3(7):730–7.

    Article  CAS  PubMed  Google Scholar 

  8. Li F, Tiede B, Massague J, et al. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res. 2007;17:3–14.

    Article  CAS  PubMed  Google Scholar 

  9. Al-Hajj M, Wicha MS, Benito-Hernandez AB, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 2003;100(7):3983–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Khan SA, Stewart AK, Morrow M. Does aggressive local therapy improve survival in metastatic breast cancer? Surgery. 2002;132(4):620–7.

    Article  PubMed  Google Scholar 

  11. Rapiti E, Verkooijen HM, Blastos G, et al. Complete excision of primary breast tumor improves survival of patients with metastatic breast cancer at diagnosis. J Clin Oncol. 2006;24(18):2743–9.

    Article  PubMed  Google Scholar 

  12. National Cancer Institute. Surveillance, Epidemiology, and End Results (SEER). http://www.seer.cancer.gov/. Accessed 24 Dec 2012.

  13. Gnerlich J, Jeffe DB, Deshpande AD, et al. Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988–2003 SEER data. Ann Surg Oncol. 2007;14(8):2187–94.

    Article  PubMed  Google Scholar 

  14. Babiera GV, Rao R, Fen L, et al. Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor. Ann Surg Oncol. 2006;13(6):776–82.

    Article  PubMed  Google Scholar 

  15. Rao R, Fen L, Kuerer HM, et al. Timing of surgical intervention for the intact primary in stage IV breast cancer patients. Ann Surg Oncol. 2008;15(6):1696–702.

    Article  PubMed  Google Scholar 

  16. Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A. 2011;98(19):10869–74.

    Article  Google Scholar 

  17. Kuran A, Fish K, Shema SJ, et al. Lifetime risks of specific breast cancer subtypes among women in four racial/ethnic groups. Breast Cancer Res. 2010;12:R99.

    Article  Google Scholar 

  18. Blanchard DK, Shetty PB, Hilsenbeck SG, Elledge RM. Association of surgery with improved survival in stage IV breast cancer patients. Ann Surg. 2008;247(5):732–8.

    Article  PubMed  Google Scholar 

  19. Bafford AC, Burstein HJ, Barkley CR, et al. Breast surgery in stage IV breast cancer: impact of staging and patient selection on overall survival. Breast Cancer Res Treat. 2009;115:7–12.

    Article  PubMed  Google Scholar 

  20. Rashan ZM, Bastiaannet E, Portielje JEA, et al. Surgery in metastatic breast cancer: patients with a favorable profile seem to have the most benefit from surgery. Eur J Surg Oncol. 2012;38:52–6.

    Article  Google Scholar 

  21. Nguyen DHA, Truong PT, Alexander C, et al. Can locoregional treatment of the primary tumor improve outcomes for women with stage IV breast cancer at diagnosis? Int J Radiat Oncol. 2012;84(1):39–45.

    Article  Google Scholar 

  22. Hazard HW, Gorla SR, Scholtens D, et al. Surgical resection of the primary tumor, chest wall control, and survival in women with metastatic breast cancer. Cancer. 2008;113(8):2011–9.

    Article  PubMed  Google Scholar 

  23. Dominici L, Najita J, Hughes M, et al. Surgery of the primary tumor does not improve survival in stage IV breast cancer. Breast Cancer Res Treat. 2011;129:459–65.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Eastern Oncology Cooperative Group. Physician and patient education materials for E2108. http://www.ecog.org/general/E2108info.html. Accessed 28 Dec 2012.

  25. Al H, Royle GT. Taylor I. Breast liver metastases – incidence, diagnosis and outcome. J R Soc Med. 1991;84(12):714–6.

    Google Scholar 

  26. Selzner M, Morse M, James J, et al. Liver metastases from breast cancer: long-term survival after curative resection. Surgery. 2000;127:383–9.

    Article  CAS  PubMed  Google Scholar 

  27. Pocard M, Pouillart P, Asselain B, et al. Hepatic resection in metastatic breast cancer: results and prognostic factors. Eur J Surg Oncol. 2000;26:155–9.

    Article  CAS  PubMed  Google Scholar 

  28. Yoshimoto M, Tada T, Saito M, et al. Surgical treatment of hepatic metastases for breast cancer. Breast Cancer Res. 2000;59(2):177–84.

    Article  CAS  Google Scholar 

  29. Vlastos G, Smith DL, Singletary SE, et al. Long-term survival after an aggressive surgical approach in patients with breast cancer hepatic metastases. Ann Surg Oncol. 2004;11(9):869–74.

    Article  PubMed  Google Scholar 

  30. Adam R, Aloia T, Krissat J, et al. Is liver resection justified for patients with hepatic metastases from breast cancer? Ann Surg Oncol. 2006;244(6):897–907.

    Article  Google Scholar 

  31. Van Walsum GAM, de Ridder JAM, Verhoef C, et al. Resection of liver metastases in patients with breast cancer: survival and prognostic factors. Eur J Surg Oncol. 2012;38:910–7.

    Article  PubMed  Google Scholar 

  32. Liu J, Deng H, Jia W, et al. Comparison of ER/PR and HER2 statuses in primary and paired liver metastatic sites of breast cancer in patients with or without treatment. J Cancer Res Clin Oncol. 2012;138:837–42.

    Article  CAS  Google Scholar 

  33. Martinez SR, Young SE, Giuliano AE, et al. The utility of estrogen receptors, progesterone receptors, and Her-2/neu status to predict survival in patients undergoing hepatic resection for breast cancer metastases. Am J Surg. 2006;191:281–3.

    Article  CAS  PubMed  Google Scholar 

  34. Abbott ED, Brouquet A, Mittendorg EA, et al. Resection of liver metastases from breast cancer: Estrogen receptor status and response to chemotherapy before metastasectomy define outcome. Surgery. 2012;151:710–6.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Rashid OM, Takabe K. The evolution of the role of surgery in the management of breast cancer lung metastasis. J Thorac Dis. 2012;4(4):420–4.

    PubMed Central  PubMed  Google Scholar 

  36. Lanza LA, Nataragan G, Roth JA, et al. Long-term survival after resection of pulmonary metastases from carcinoma of the breast. Ann Thorac Surg. 1992;54:244–8.

    Article  CAS  PubMed  Google Scholar 

  37. McDonald ML, Deschamps C, Illstrup DM, et al. Pulmonary resection for metastatic breast cancer. Ann Thorac Surg. 1994;58:1599–602.

    Article  CAS  PubMed  Google Scholar 

  38. Friedel G, Pastorino U, Ginsberg RJ, et al. Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases. Eur J Cardiothorac Surg. 2002;22:335–44.

    Article  PubMed  Google Scholar 

  39. Tanaka F, Li M, Hanaoka N. Surgery for pulmonary nodules in breast cancer patients. Ann Thorac Surg. 2005;79:1711–5.

    Article  PubMed  Google Scholar 

  40. Rena O, Papalia E, Ruffini E, et al. The role of surgery in the management of solitary pulmonary nodule in breast cancer patients. Eur J Surg Oncol. 2007;33:546–60.

    Article  CAS  PubMed  Google Scholar 

  41. Welter S, Jacobs J, Krbek T, et al. Pulmonary metastases of breast cancer. When is resection indicated? Eur J Cardiothorac Surg. 2008;34(6):1228–34.

    Article  PubMed  Google Scholar 

  42. Nichols FC. Pulmonary metastasectomy. Thorac Surg Clin. 2012;22:91–9. vii.

    Article  PubMed  Google Scholar 

  43. Tsukada Y, Fouad A, Pickren JW, et al. Central nervous system metastasis from breast carcinoma. Autopsy study. Cancer. 1983;52(12):2349–54.

    Article  CAS  PubMed  Google Scholar 

  44. Quigley MR, Fukui O, Chew B, et al. The shifting landscape of metastatic breast cancer to the CNS. Neurosurg Rev. 2013;36(3):377–82.

    Google Scholar 

  45. Patchell RA, Tibbs PA, Walsh JW, et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med. 1990;322:494–500.

    Article  CAS  PubMed  Google Scholar 

  46. Patchell R, Tibbs PA, Regine WF, et al. Post-operative radiation therapy in the treatment of single metastases to the brain. JAMA. 1998;280(17):1485–9.

    Article  CAS  PubMed  Google Scholar 

  47. Rades D, Pluemer A, Beninga T, et al. A boost in addition to whole brain radiotherapy improves patient outcome after resection of 1–2 brain metastases in recursive partitioning analysis class 1 and 2 patients. Cancer. 2007;110(7):1551–9.

    Article  PubMed  Google Scholar 

  48. Rades D, Kueter JD, Gliemroth J, et al. Resection plus whole-brain irradiation versus resection plus whole-brain irradiation plus boost for the treatment of single brain metastasis. Strahlenther Onkol. 2012;188:143–7.

    Article  CAS  PubMed  Google Scholar 

  49. Tsao MN, Lloyd N, Wong RKS, et al. Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases (Review). The Cochrane Collaboration. http://www.thecochranelibrary.com.

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Correspondence to Hannah W. Hazard MD, FACS .

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Hazard, H.W. (2015). Operative Management of Metastatic Breast Cancer. In: Riker, A. (eds) Breast Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1145-5_16

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  • DOI: https://doi.org/10.1007/978-1-4939-1145-5_16

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