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III.L. Proliferative Diabetic Vitreoretinopathy

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Vitreous

Abstract

This chapter reviews the pathogenesis of proliferative diabetic vitreoretinopathy (PDVR) and presents recommendations for its clinical staging. Although numerous biochemical mediators may be responsible for the pathogenesis of PDVR, there is no consensus about the biochemical pathway(s) responsible for the progression of PDVR. Among the known and most studied mediators is vascular endothelial growth factor (VEGF) [18]. Since the thickened posterior vitreous cortex is one of the main components in proliferative diabetic retinopathy (PDR) causing the subsequent development of retinal proliferations, shrinkage of the diabetic posterior vitreous cortex leads to traction retinal detachment. Although several classifications are described in the literature, the classification suggested herein is important in the clinical assessment of disease severity, the communication about the disease state, and the evaluation of therapy. A new morphological classification of PDVR is presented which emphasizes the role of vitreous, hence the name PDVR. Moreover, this classification reliably predicts the surgical outcome in advanced stages of PDVR.

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Authors and Affiliations

  1. Department of Ophthalmology, Philipps-University, Marburg, Germany

    Peter Kroll MD, Eduardo B. Rodrigues MD & Carsten H. Meyer MD, FEBO, FMH

  2. Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, CH-5000, Brazil

    Eduardo B. Rodrigues MD

  3. Department of Ophthalmology, Pallas Clinic, Aarau, CH-5000, Switzerland

    Carsten H. Meyer MD, FEBO, FMH

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  1. Peter Kroll MD
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  2. Eduardo B. Rodrigues MD
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  3. Carsten H. Meyer MD, FEBO, FMH
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Correspondence to Peter Kroll MD .

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Editors and Affiliations

  1. VMR Institute for Vitreous Macula Retina, Huntington Beach, California, USA

    J. Sebag

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Kroll, P., Rodrigues, E.B., Meyer, C.H. (2014). III.L. Proliferative Diabetic Vitreoretinopathy. In: Sebag, J. (eds) Vitreous. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1086-1_24

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  • DOI: https://doi.org/10.1007/978-1-4939-1086-1_24

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