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Neuroinflammation and Neurodegeneration pp 291–308Cite as

Congenital Cytomegalovirus Disease

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Abstract

Of the myriad of congenitally and perinatally acquired infections that can impair the neurodevelopment of the infant, cytomegalovirus (CMV) is the most important. In the developed world, congenital CMV infection occurs in approximately 1 % of all pregnancies. Long-term neurodevelopmental disabilities include developmental delay, cerebral palsy, seizure disorders, and sensorineural hearing loss. This chapter summarizes the epidemiology and impact of congenital CMV on brain development. Hypotheses regarding the pathophysiology of CNS injury are reviewed. Prospects for intervention are also summarized.

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Authors and Affiliations

  1. Department of Pediatrics, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, 3-214 MTRF, 2001 6th Street SE, Minneapolis, MN, 55455, USA

    Mark R. Schleiss M.D.

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  1. Mark R. Schleiss M.D.
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Correspondence to Mark R. Schleiss M.D. .

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  1. Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA

    Phillip K. Peterson

  2. Department of Biochemistry Department of Molecular Biology, University of Miami School of Medicine, Miami, Florida, USA

    Michal Toborek

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Schleiss, M.R. (2014). Congenital Cytomegalovirus Disease. In: Peterson, P., Toborek, M. (eds) Neuroinflammation and Neurodegeneration. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1071-7_14

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