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The Right Ventricle in Health and Disease pp 455–469Cite as

Animal Models of Chronic Right Ventricular Stress and Failure

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  • 2015 Accesses

Part of the book series: Respiratory Medicine ((RM))

Abstract

Animal models of diseases are of pivotal importance for the investigation of the normal organ function, the pathobiology of frequent and rare disorders as well as for preclinical proof of principle studies. It has been noticed that there are substantial gaps between our knowledge and understanding of left and right heart failure. To a large extent the concepts underlying right ventricular failure (RVF) have been borrowed from models of left heart failure or extrapolated from models of acute RVF. Today, several models of pulmonary hypertension are used by investigators and the aim of this chapter is to review current models of adaptive and maladaptive right ventricular hypertrophy in small and large animals. We discuss the pros and cons of each model depending on the particular disease aspect which the investigator attempts to reproduce, and we make a case for the development of new animal models of chronic RVF.

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Author information

Authors and Affiliations

  1. Department of Immunology, University of Pittsburgh, 3002 E. Broad Street, APT B, Richmond, VA, 23223, USA

    Jose Gomez-Arroyo M.D., Ph.D.

  2. Department of Pulmonary Medicine, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands

    Michiel Alexander de Raaf M.Sc., B.A.Sc. & Harm Jan Bogaard M.D., Ph.D.

  3. Department of Medicine, Virginia Commonwealth University, 1220 E. Brodd Street, Richmond, VA, 23298, USA

    Norbert F. Voelkel M.D.

Authors
  1. Jose Gomez-Arroyo M.D., Ph.D.
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  2. Michiel Alexander de Raaf M.Sc., B.A.Sc.
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  3. Harm Jan Bogaard M.D., Ph.D.
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  4. Norbert F. Voelkel M.D.
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Corresponding author

Correspondence to Jose Gomez-Arroyo M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA

    Norbert F. Voelkel

  2. Pediatric Heart Center, Justus-Liebig University, Giessen, Germany

    Dietmar Schranz

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Gomez-Arroyo, J., de Raaf, M.A., Bogaard, H.J., Voelkel, N.F. (2015). Animal Models of Chronic Right Ventricular Stress and Failure. In: Voelkel, N., Schranz, D. (eds) The Right Ventricle in Health and Disease. Respiratory Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1065-6_22

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  • DOI: https://doi.org/10.1007/978-1-4939-1065-6_22

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1064-9

  • Online ISBN: 978-1-4939-1065-6

  • eBook Packages: MedicineMedicine (R0)

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