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The Right Ventricle in Health and Disease pp 265–281Cite as

Cardiac MRI and PET Scanning in Right Ventricular Failure

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Part of the book series: Respiratory Medicine ((RM))

Abstract

Right ventricular (RV) failure is the main determinant of short-term survival in patients with pulmonary arterial hypertension (PAH). The pathophysiology of the development of RV failure has been incompletely understood. Cardiac magnetic resonance imaging (MRI) and positron emission tomography (PET) are advanced, noninvasive imaging techniques that provide in vivo assessment of the RV. These techniques do not only allow global RV morphological and functional evaluation but also enable to study myocardial tissue processes such as perfusion and blood flow, metabolism, neurohormonal activation, and molecular processes such as angiogenesis and apoptosis. Clinical application of advanced imaging techniques have contributed to the discovery of risk factors, monitoring of therapeutic effects, and determination of prognostic factors in patients with PAH. In addition, current and future applications of MRI and PET will likely lead to a better understanding of the pathophysiological pathways that contribute to the development of RV failure. In the near future it can be expected that application of hybrid PET-MRI could be one of the most important developments in order to allow simultaneous, integrated assessment of multiple RV disease processes in vivo.

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Acknowledgements

We would like to thank Dr. Hans Harms for his support of the image collection.

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  1. Department of Physics & Medical Technology, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1007 MB, The Netherlands

    J. Tim Marcus Ph.D.

  2. Department of Pulmonary Medicine, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1007 MB, The Netherlands

    Harm-Jan Bogaard M.D., Ph.D. & Anton Vonk Noordegraaf M.D., Ph.D.

Authors
  1. Mariëlle C. van de Veerdonk
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  2. J. Tim Marcus Ph.D.
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  3. Harm-Jan Bogaard M.D., Ph.D.
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  4. Anton Vonk Noordegraaf M.D., Ph.D.
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Corresponding author

Correspondence to Anton Vonk Noordegraaf M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA

    Norbert F. Voelkel

  2. Pediatric Heart Center, Justus-Liebig University, Giessen, Germany

    Dietmar Schranz

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van de Veerdonk, M.C., Marcus, J.T., Bogaard, HJ., Noordegraaf, A.V. (2015). Cardiac MRI and PET Scanning in Right Ventricular Failure. In: Voelkel, N., Schranz, D. (eds) The Right Ventricle in Health and Disease. Respiratory Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1065-6_12

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  • DOI: https://doi.org/10.1007/978-1-4939-1065-6_12

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1064-9

  • Online ISBN: 978-1-4939-1065-6

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