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Lasso Peptide Bioengineering and Bioprospecting

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Lasso Peptides

Part of the book series: SpringerBriefs in Microbiology ((BRIEFSMICROBIOL))

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Abstract

Lasso peptides are ribosomally synthesized, post-translationally modified peptides produced by bacteria. They share an interlocked topology, consisting of a macrolactam ring at the N-terminus and a C-terminal tail that is threaded through the ring and is firmly trapped inside. This compact and constrained structure gives high stability to lasso peptides, which can thus be applied as a molecular framework for developing bioactive peptides. The chemical and genetic diversity of lasso peptides is revealed by mining microbial genomes. This chapter will present concepts and advances on lasso peptide engineering as well as information gained from genome-mining studies. To conclude, perspectives in the lasso peptide research will be discussed.

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Authors and Affiliations

  1. Laboratory of Communication Molecules and Adaptation of Microorganisms, Muséum National d’Histoire Naturelle CNRS, Paris, France

    Yanyan Li, Séverine Zirah & Sylvie Rebuffat

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  1. Yanyan Li
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  2. Séverine Zirah
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  3. Sylvie Rebuffat
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Correspondence to Yanyan Li .

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© 2015 Yanyan Li, Séverine Zirah and Sylvie Rebuffat

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Li, Y., Zirah, S., Rebuffat, S. (2015). Lasso Peptide Bioengineering and Bioprospecting. In: Lasso Peptides. SpringerBriefs in Microbiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1010-6_5

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