Abstract
Morphea (localized scleroderma) is an autoimmune disease characterized by sclerosis of the skin and, in some cases, subcutaneous tissue. It occurs in children and adults. It is distinct from systemic sclerosis, but may nevertheless be associated with significant functional and cosmetic impairment. Morphea has several distinct subtypes, including circumscribed, linear, and generalized, all of which can occur in superficial and deep forms. The linear subtype is more common in children, and the circumscribed is more common in adults. Evaluation is aimed at confirming the diagnosis and clinical subtype, assessing the stage of activity, and determining the potential for/or the presence of morbidity. Therapy includes topical, phototherapy, or systemic treatments and is aimed at halting progression, preventing morbidity, and speeding remission.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Saxton-Daniels S, Jacobe HT. An evaluation of long-term outcomes in adults with pediatric-onset morphea. Arch Dermatol. 2010;146(9):1044–5.
Laxer RM, Zulian F. Localized scleroderma. Curr Opin Rheumatol. 2006;18(6):606–13.
Zwischenberger BA, Jacobe HT. A systematic review of morphea treatments and therapeutic algorithm. J Am Acad Dermatol. 2011;65(5):925–41.
Nezafati KA, Cayce RL, Susa JS, Setiawan AT, Tirkes T, Bendeck SE, Jacobe HT. 14-MHz ultrasonography as an outcome measure in morphea (localized scleroderma). Arch Dermatol. 2011;147(9):1112–5.
Chiu YE, Vora S, Kwon EK, Maheshwari M. A significant proportion of children with morphea en coup de sabre and Parry-Romberg syndrome have neuroimaging findings. Pediatr Dermatol. 2012;29(6):738–48.
Li SC, Torok KS, Pope E, Dedeoglu F, Hong S, Jacobe HT, Egla Rabinovich C, Laxer RM, Higgins GC, Lasky A, Baszis K, Becker M, Campillo S, Cartwright V, Cidon M, Inman CJ, Jerath R, O’Neil KM, Vora S, Zeft A, Wallace CA, Ilowite NT, Fuhlbrigge RC. Development of consensus treatment plans for juvenile localized scleroderma. Arthritis Care Res. 2012;64(8):1175–85.
Zulian F, Martini G, Vallongo C, Vittadello F, Falcini F, Patrizi A, Alessio M, Torre FL, Podda RA, Gerloni V, Cutrone M, Belloni-Fortina A, Paradisi M, Martino S, Perilongo G. Methotrexate treatment in juvenile localized scleroderma: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2011;63(7):1998–2006.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Bangert, C.A., Kim, A., Jacobe, H. (2014). Localized Scleroderma. In: Mayes, M. (eds) A Visual Guide to Scleroderma and Approach to Treatment. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0980-3_2
Download citation
DOI: https://doi.org/10.1007/978-1-4939-0980-3_2
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-0979-7
Online ISBN: 978-1-4939-0980-3
eBook Packages: MedicineMedicine (R0)