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Astroglial Connexins as Elements of Sleep-Wake Cycle Regulation and Dysfunction

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Pathological Potential of Neuroglia

Abstract

Sleep is fundamental for survival of animals and humans. Minor perturbations in sleep duration or timing can lead to cognitive impairments. Patients with sleep disorders suffer from high health risks and poor quality of life. Mechanisms of sleep function and their dysfunction are still far from being understood and concepts based on novel hypotheses are required. Discovery of dynamic neuronal-glial interaction has offered the opportunity to perceive sleep-wake cycle from another angle. Here, we summarize data indicating how astrocytes can contribute to the regulation of sleep, with a focus on the roles of astrocytic in adenosine homeostasis and metabolism. Also, we discuss evidence indicating that several treatments known to affect sleep-wake cycle have an impact on connexin-mediated astroglial networking. We further hypothesize that sleep homeostasis will be affected by pharmacological or genetic modifications of connexin channel functions in astrocytes. Taken together, accumulating knowledge on astrocyte functions in sleep-wake cycle implicates the glial cells as promising new therapeutic targets for sleep disorders treatment.

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Acknowledgements

Works presented in this have been supported by the ANR grant AstroSleep NANR-12-BSV4-0013-01. The authors wish to thank Pr. P. Magistretti, Dr. J-M Petit, Pr. J. Mantz and Dr. S. Kandelam for helpful discussions related to Cx roles in the regulation of sleep-wake cycle .

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  1. Center of Interdisciplinary Research in Biology, Collège de France, 11 place Marcelin Berthelot, 75005, Paris, France

    Xinhe Liu & Dr. Christian Giaume

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  1. Xinhe Liu
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  2. Dr. Christian Giaume
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Correspondence to Christian Giaume .

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  1. Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

    Vladimir Parpura

  2. Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

    Alexei Verkhratsky

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Liu, X., Giaume, C. (2014). Astroglial Connexins as Elements of Sleep-Wake Cycle Regulation and Dysfunction. In: Parpura, V., Verkhratsky, A. (eds) Pathological Potential of Neuroglia. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0974-2_18

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