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Prediction and Management of Severe Acute Pancreatitis pp 101–113Cite as

Fluid Resuscitation in Acute Pancreatitis

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Abstract

Acute pancreatitis is a common inflammatory disorder of the pancreas resulting in considerable morbidity and a mortality rate of approximately 5 %. Although there are no pharmacologic treatments known to improve important outcomes, aggressive intravenous fluid resuscitation is generally recommended in all patients. Recent human investigations have been performed in an attempt to answer several important questions that have not been answered, particularly in reference to the optimal resuscitative fluid, the role for colloid solutions, the ideal target clinical marker for fluid resuscitation, as well as the ideal time points for fluid administration. This review begins with a discussion related to the microcirculation of the pancreas and the pathophysiologic alterations caused by acute pancreatitis. Previous animal experiments will be described, as will the current status of recent and planned human studies specifically addressing fluid resuscitation. Finally, current recommendations and goals for further investigation will be highlighted. It is our hope that this review will stimulate interest in this previously overlooked subject and lead to further carefully designed prospective human clinical trials in the future.

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References

  1. National Center for Health Statistics. National hospital discharge summary: annual summary 1998; series report 13:203.

    Google Scholar 

  2. DeFrances CJ, Hall MJ, Podgornik MN. National Hospital Discharge Survey: advance data from vital and health statistics. Hyattsville, MD: National Center for Health Statistics; 2005. p. 359.

    Google Scholar 

  3. Mann DV, Hershman MJ, Hittinger R, Glazer G. Multicentre audit of death from acute pancreatitis. Br J Surg. 1984;81:890–3.

    Google Scholar 

  4. Neoptolemos JP, Raraty M, Finch M, Sutton R. Acute pancreatitis: the substantial human and financial costs. Gut. 1998;42:886–91.

    PubMed  CAS  PubMed Central  Google Scholar 

  5. Blum T, Lowenfels AB, Lankisch PG. Fatal outcome in acute pancreatitis: its occurrence and early prediction. Pancreatology. 2001;1:237–41.

    PubMed  CAS  Google Scholar 

  6. Appelros S, Lindgren S, Borgstrom A. Short and long term outcome of severe acute pancreatitis. Eur J Surg. 2001;167:281–6.

    PubMed  CAS  Google Scholar 

  7. Vege SS, Baron TH. Management of pancreatic necrosis in severe acute pancreatitis. Clin Gastroenterol Hepatol. 2005;3:192–6.

    PubMed  Google Scholar 

  8. Morimoto T, Noguchi Y, Sakai T, Shimbo T, Fukui T. Acute pancreatitis and the role of histamine-2 receptor antagonists: a meta-analysis of randomized controlled trials of cimetidine. Eur J Gastroenterol Hepatol. 2002;14:679–86.

    PubMed  CAS  Google Scholar 

  9. Cameron J, Mehigan D, Zuidema GD. Evaluation of atropine in acute pancreatitis. Surg Gynecol Obstet. 1979;148:206–8.

    PubMed  CAS  Google Scholar 

  10. Testoni PA, Bagnolo F, Andriulli A, Bernasconi G, Crotta S, Lella F, et al. Octreotide 24-h prophylaxis in patients at high risk for post-ERCP pancreatitis: results of a multicenter, randomized, controlled trial. Aliment Pharmacol Ther. 2001;15:965–72.

    PubMed  CAS  Google Scholar 

  11. Uhl W, Buchler MW, Malfertheiner P, Beger HG, Adler G, Gaus W. A randomised, double blind, multicentre trial of octreotide in moderate to severe acute pancreatitis. Gut. 1999;45:97–104.

    PubMed  CAS  PubMed Central  Google Scholar 

  12. Hirata K. Essential therapeutic strategies for acute pancreatitis—guidelines for initial treatment and their significance. Nippon Rinsho. 2004;62:2049–56.

    PubMed  Google Scholar 

  13. Andriulli A, Leandro G, Clemente R, Festa V, Caruso N, Annese V, et al. Meta-analysis of somatostatin, octreotide and gabexate mesilate in the therapy of acute pancreatitis. Aliment Pharmacol Ther. 1998;12:237–45.

    PubMed  CAS  Google Scholar 

  14. Heinrich S, Schafer M, Rousson V, Clavien PA. Evidence-based treatment of acute pancreatitis: a look at established paradigms. Ann Surg. 2006;243:154–68.

    PubMed  PubMed Central  Google Scholar 

  15. Imrie CW, McKay CJ. The possible role of platelet-activating factor antagonist therapy in the management of severe acute pancreatitis. Baillieres Best Pract Res Clin Gastroenterol. 1999;13:357–64.

    PubMed  CAS  Google Scholar 

  16. Elmunzer BJ, Scheiman JM, Lehman GA, Chak A, Mosler P, Higgins PD, et al. A randomized trial of rectal indomethacin to prevent post-ERCP Pancreatitis. N Engl J Med. 2012;366:1414–22.

    PubMed  CAS  PubMed Central  Google Scholar 

  17. Folsch UR, Nitsche R, Ludtke R, Hilgers RA, Creutzfeldt W. Early ERCP and papillotomy compared with conservative treatment for acute biliary pancreatitis. N Engl J Med. 1997;336:237–42.

    PubMed  CAS  Google Scholar 

  18. Tenner S. Initial management of acute pancreatitis: critical issues during the first 72 hours. Am J Gastroenterol. 2004;99:2489–94.

    PubMed  Google Scholar 

  19. Bockman D. An introduction to surgical anatomy and neuroanatomy. In: Beger HC et al., editors. The Pancreas, vol. 1. Oxford: Blackwell Science Ltd; 1998. p. 11–8.

    Google Scholar 

  20. Cuthbertson CM, Christophi C. Disturbances of the microcirculation in acute pancreatitis. Br J Surg. 2006;93:518–30.

    PubMed  CAS  Google Scholar 

  21. Mikami Y, Takeda K, Murakami T, et al. Vascular anatomy of the pancreas. In: Pour P, editor. Toxicology of the pancreas. Boca Raton, FL: Taylor & Francis; 2006. p. 75–89.

    Google Scholar 

  22. Sweiry JH, Mann GE. Pancreatic microvascular permeability in caerulein-induced acute pancreatitis. Am J Physiol. 1991;261:G685–92.

    PubMed  CAS  Google Scholar 

  23. Bonner-Weir S. The microvasculature of the pancreas, with emphasis on that of the iselt of Langerhans. In: Go VLW et al., editors. The pancreas: biology, pathobiology and disease. 2nd ed. New York: Raven; 1993. p. 759–68.

    Google Scholar 

  24. Plusczyk T, Rathgeb D, Westermann S, Feifel G. Effects of somatostatin (SMS) on pancreatic microcirculation. Dig Dis Sci. 1997;42:2254–63.

    PubMed  CAS  Google Scholar 

  25. Knoefel WT, Kollias N, Warshaw A, Waldner H, Nishioka NS, Rattner DW. Pancreatic microcirculatory changes in experimental pancreatitis of graded severity in rat. Surgery. 1994;116:904–13.

    PubMed  CAS  Google Scholar 

  26. Strate T, Mann O, Kleinhans H, Rusani S, Schneider C, Yekebas E, et al. Microcirculatory function and tissue damage is improved after therapeutic injection of bovine hemoglobin in severe acute rodent pancreatitis. Pancreas. 2005;30:254–9.

    PubMed  CAS  Google Scholar 

  27. Bassi D, Kollias N, Fernandez-del Castillo C, Foitzik T, Warshaw AL, Rattner DW. Impairment of pancreatic microcirculation correlates with the severity of acute experimental pancreatitis. J Am Coll Surg. 1994;179:257–63.

    PubMed  CAS  Google Scholar 

  28. Borodin YI, Vasilyeva MB, Larionov PM, Astashov VV, Yankaite EV. Hemolymphomicrocirculatory bed of the pancreas during acute experimental pancreatitis. Bull Exp Biol Med. 2006;141:491–2.

    PubMed  Google Scholar 

  29. Pandol SJ, Saluja AK, Imrie CW, Banks PA. Acute pancreatitis: bench to the bedside. Gastroenterology. 2007;132:1127–51.

    PubMed  CAS  Google Scholar 

  30. Foitzik T, Hotz HG, Eibl G, Hotz B, Kirchengast M, Buhr HJ. Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of platelet-activating factor receptor blockade vs. endothelin receptor blockade. J Gastrointest Surg. 1999;3:244–51.

    PubMed  CAS  Google Scholar 

  31. Foitzik T, Eibl G, Buhr HJ. Therapy for microcirculatory disorders in severe acute pancreatitis: comparison of delayed therapy with ICAM-1 antibodies and a specific endothelin A receptor antagonist. J Gastrointest Surg. 2000;4:240–6.

    PubMed  CAS  Google Scholar 

  32. Freitag M, Standl TG, Kleinhans H, Gottschalk A, Mann O, Rempf C, et al. Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis. Pancreatology. 2006;6:232–9.

    PubMed  CAS  Google Scholar 

  33. Kerner T, Vollmar B, Menger MD, Waldner H, Messmer K. Determinants of pancreatic microcirculation in acute pancreatitis in rats. J Surg Res. 1996;62:165–71.

    PubMed  CAS  Google Scholar 

  34. Takada Y, Appert HE, Howard JM. Vascular permeability induced by pancreatic exudate formed during acute pancreatitis in dogs. Surg Gynecol Obstet. 1976;143:779–83.

    PubMed  CAS  Google Scholar 

  35. Bockman DE. Microvasculature of the pancreas: relation to pancreatitis. Int J Pancreatol. 1992;12:11–21.

    PubMed  CAS  Google Scholar 

  36. Vollmar B, Menger MD. Microcirculatory dysfunction in acute pancreatitis: a new concept of pathogenesis involving vasomotion-associated arteriolar constriction and dilation. Pancreatology. 2003;3:181–90.

    PubMed  Google Scholar 

  37. Sanfey H, Cameron JL. Increased capillary permeability: an early lesion in acute pancreatitis. Surgery. 1984;96:485–91.

    PubMed  CAS  Google Scholar 

  38. Klar E, Messmer K, Warshaw AL, Herfarth C. Pancreatic ischaemia in experimental acute pancreatitis: mechanism, significance and therapy. Br J Surg. 1990;77:1205–10.

    PubMed  CAS  Google Scholar 

  39. Zhou ZG, Chen YD. Influencing factors of pancreatic microcirculatory impairment in acute pancreatitis. World J Gastroenterol. 2002;8:2103–11.

    Google Scholar 

  40. Klar E, Schratt W, Foitzik T, Buhr H, Herfarth C, Messmer K. Impact of microcirculatory flow pattern changes on the development of acute edematous and necrotizing pancreatitis in rabbit pancreas. Dig Dis Sci. 1994;39:2639–44.

    PubMed  CAS  Google Scholar 

  41. Klar E, Endrich B, Messmer K. Microcirculation of the pancreas. A quantitative study of physiology and changes in pancreatitis. Int J Microcirc Clin Exp. 1990;9:85–101.

    PubMed  CAS  Google Scholar 

  42. Kusterer K, Poschmann T, Friedemann A, Enghofer M, Zendler S, Usadel KH. Arterial constriction, ischemia-reperfusion, and leukocyte adherence in acute pancreatitis. Am J Physiol. 1993;265:G165–71.

    PubMed  CAS  Google Scholar 

  43. Schroder T, Kivisaari L, Standertskjold-Nordenstam CG, Somer K, Lehtola A, Puolakkainen P, et al. Pancreatic blood flow and contrast enhancement in computed tomography during experimental pancreatitis. Eur Surg Res. 1985;17:286–91.

    PubMed  CAS  Google Scholar 

  44. Takeda K. Role of increase in permeability and circulatory failure in the development of organ dysfunction in severe acute pancreatitis. Nippon Rinsho. 2004;62:1999–2004.

    PubMed  Google Scholar 

  45. Ranson JH, Lackner H, Berman IR, Schinella R. The relationship of coagulation factors to clinical complications of acute pancreatitis. Surgery. 1977;81:502–11.

    PubMed  CAS  Google Scholar 

  46. Salomone T, Tosi P, Palareti G, Tomassetti P, Migliori M, Guariento A, et al. Coagulative disorders in human acute pancreatitis: role for the D-dimer. Pancreas. 2003;26:111–6.

    PubMed  CAS  Google Scholar 

  47. Toyama MT, Lewis MP, Kusske AM, Reber PU, Ashley SW, Reber HA. Ischaemia-reperfusion mechanisms in acute pancreatitis. Scand J Gastroenterol Suppl. 1996;219:20–3.

    PubMed  CAS  Google Scholar 

  48. Bhatnagar A, Wig JD, Majumdar S. Expression of activation, adhesion molecules and intracellular cytokines in acute pancreatitis. Immunol Lett. 2001;77:133–41.

    PubMed  CAS  Google Scholar 

  49. Rau B, Poch B, Gansauge F, Bauer A, Nüssler AK, Nevalainen T, et al. Pathophysiologic role of oxygen free radicals in acute pancreatitis: initiating event or mediator of tissue damage? Ann Surg. 2000;231:352–60.

    PubMed  CAS  PubMed Central  Google Scholar 

  50. Schoenberg MH, Buchler MW, Younes M, Kirchmayr R, Brückner UB, Beger HG. Effect of antioxidant treatment in rats with acute hemorrhagic pancreatitis. Dig Dis Sci. 1994;39:1034–40.

    PubMed  CAS  Google Scholar 

  51. Takeda K, Mikami Y, Fukuyama S, Egawa S, Sunamura M, Ishibashi T, et al. Pancreatic ischemia associated with vasospasm in the early phase of human acute necrotizing pancreatitis. Pancreas. 2005;30:40–9.

    PubMed  Google Scholar 

  52. Baron TH, Thaggard WG, Morgan DE, Stanley RJ. Endoscopic therapy for organized pancreatic necrosis. Gastroenterology. 1996;111:755–64.

    PubMed  CAS  Google Scholar 

  53. Dimagno MJ, Williams JA, Hao Y, Ernst SA, Owyang C. Endothelial nitric oxide synthase is protective in initiation of caerulein-induced acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2004;287:G80–7.

    PubMed  CAS  Google Scholar 

  54. Eibl G, Hotz HG, Faulhaber J, Kirchengast M, Buhr HJ, Foitzik T. Effect of endothelin and endothelin receptor bloackade on capillary permeability in experimental pancreatitis. Gut. 2000;46:390–4.

    PubMed  CAS  PubMed Central  Google Scholar 

  55. Hackert T, Werner J, Gebhard MM, Klar E. Effects of heparin in experimental models of acute pancreatitis and post-ERCP pancreatitis. Surgery. 2004; 135:131–8.

    PubMed  Google Scholar 

  56. Zyromski N, Murr MM. Evolving concepts in the pathophysiology of acute pancreatitis. Surgery. 2003;133:235–7.

    PubMed  Google Scholar 

  57. Pezzilli R, Fantini L, Morselli-Labate AM. New approaches for the treatment of acute pancreatitis. Pancreas. 2006;7:79–91.

    Google Scholar 

  58. Hughes CB, Grewal HP, Gaber LW, Kotb M, El-din AB, Mann L. Anti- TNF-a therapy improves survival and ameliorates the pathophysiology sequelae in acute pancreatitis in the rat. Am J Surg. 1996;171:274–80.

    PubMed  CAS  Google Scholar 

  59. Hughes CB, Gaber LW, Mohey el-Din AB, Grewal HP, Kotb M, Mann L, et al. Inhibition of TNF alpha improves survival in an experimental model of acute pancreatitis. Am Surg. 1996;62:8–13.

    PubMed  CAS  Google Scholar 

  60. Norman J, Franz M, Messina J, Riker A, Fabri PJ, Rosemurgy AS, et al. Interleukin-1 receptor antagonist decreases severity of experimental acute pancreatitis. Surgery. 1995;117:648–55.

    PubMed  CAS  Google Scholar 

  61. Li W, Yan X, Wang H, Zhang Z, Yu W, Ji D, et al. Effects of continuous high-volume hemofiltration on experimental severe acute pancreatitis in pigs. Pancreas. 2007;34:112–9.

    PubMed  Google Scholar 

  62. Wang HLW, Zhou W, Li N, Li JS. Clinical effects of continuous high volume hemofiltration on severe acute pancreatitis complicated with multiple organ dysfunction syndrome. World J Gastroenterol. 2003;9:2096–9.

    PubMed  Google Scholar 

  63. Banks PA, Freeman ML. Practice guidelines in acute pancreatitis. Am J Gastroenterol. 2006;101:2379–400.

    PubMed  Google Scholar 

  64. Baron TH, Morgan DE. Acute necrotizing pancreatitis. N Engl J Med. 1999;340:1412–7.

    PubMed  CAS  Google Scholar 

  65. Clancy TE, Ashley SW. Current management of necrotizing pancreatitis. Adv Surg. 2002;36: 103–21.

    PubMed  Google Scholar 

  66. Purcaru F, Ghelase F, Gugila I, Curcă T, Nemeş R, Georgescu I, et al. Resuscitation principles in severe acute pancreatitis complicated by multiple organ dysfunctions. Chirurgia. 1997;92:309–23.

    PubMed  CAS  Google Scholar 

  67. Horton JW, Burnweit CA. Hemodynamic function in acute pancreatitis. Surgery. 1988;103:538–46.

    PubMed  CAS  Google Scholar 

  68. Juvonen PO, Tenhunen JJ, Heino AA, Merasto M, Paajanen HE, Alhava EM, et al. Splanchnic tissue perfusion in acute experimental pancreatitis. Scand J Gastroenterol. 1999;34:308–14.

    PubMed  CAS  Google Scholar 

  69. Niederau C, Crass RA, Silver G, Ferrell LD, Grendell JH. Therapeutic regimens in acute experimental hemorrhagic pancreatitis. Effects of hydration, oxygenation, peritoneal lavage, and a potent protease inhibitor. Gastroenterology. 1988;95:1648–57.

    PubMed  CAS  Google Scholar 

  70. Knol JA, Inman MG, Strodel WE, Eckhauser FE. Pancreatic response to crystalloid resuscitation in experimental pancreatitis. J Surg Res. 1987;43:387–92.

    PubMed  CAS  Google Scholar 

  71. Martin DT, Steinberg SM, Kopolovic R, Carey LC, Cloutier CT. Crystalloid versus colloid resuscitation in experimental hemorrhagic pancreatitis. Surg Gynecol Obstet. 1984;159:445–9.

    PubMed  CAS  Google Scholar 

  72. Shields CJ, Winter DC, Sookhai S, Ryan L, Kirwan WO, Redmond HP. Hypertonic saline attenuates end-organ damage in an experimental model of acute pancreatitis. Br J Surg. 2000;87: 1336–40.

    PubMed  CAS  Google Scholar 

  73. Shields CJ, Sookhai S, Winter DC, Dowdall JF, Kingston G, Parfrey N, et al. Attenuation of pancreatitis-induced pulmonary injury by aerosolized hypertonic saline. Surg Infect. 2001;2:215–23.

    CAS  Google Scholar 

  74. Schmidt J, Fernandez-del Castillo C, Rattner DW, Lewandrowski KB, Messmer K, Warshaw AL. Hyperoncotic ultrahigh molecular weight dextran solutions reduce trypsinogen activation, prevent acinar necrosis, and lower mortality in acute pancreatitis. Am J Surg. 1993;165:40–4.

    PubMed  CAS  Google Scholar 

  75. Schmidt J, Huch K, Mithofer K, Hotz HG, Sinn HP, Buhr HJ, et al. Benefits of various dextrans after delayed therapy in necrotizing pancreatitis of the rat. Intensive Care Med. 1996;22:1207–13.

    PubMed  CAS  Google Scholar 

  76. Donaldson LA, Schenk WJ. Experimental acute pancreatitis: the changes in pancreatic oxygen consumption and the effect of Dextran 40. Ann Surg. 1979;190:728–31.

    PubMed  CAS  PubMed Central  Google Scholar 

  77. Klar E, Foitzik T, Buhr H, Messmer K, Herfarth C. Isovolemic hemodilution with dextran 60 as treatment of pancreatic ischemia in acute pancreatitis. Clinical practicability of an experimental concept. Ann Surg. 1993;217:369–74.

    PubMed  CAS  PubMed Central  Google Scholar 

  78. Klar E, Herfarth C, Messmer K. Therapeutic effect of isovolemic hemodilution with dextran 60 on impairment of pancreatic microcirculation in acute biliary pancreatitis. Ann Surg. 1990;211: 346–53.

    PubMed  CAS  PubMed Central  Google Scholar 

  79. Knol JA, Edgcomb LP, Inman MG, Eckhauser FE. Low molecular weight dextran in experimental pancreatitis: effects on pancreatic microcirculation. J Surg Res. 1983;35:73–82.

    PubMed  CAS  Google Scholar 

  80. Horton JW, Dunn CW, Burnweit CA, Walker PB. Hypertonic saline-dextran resuscitation of acute canine bile-induced pancreatitis. Am J Surg. 1989;158:48–56.

    PubMed  CAS  Google Scholar 

  81. Strate T, Mann O, Kleinhans H, Schneider C, Knoefel WT, Yekebas E, et al. Systemic intravenous infusion of bovine hemoglobin significantly reduces microcirculatory dysfunction in experimentally induced pancreatitis in the rat. Ann Surg. 2003;238:765–71.

    PubMed  PubMed Central  Google Scholar 

  82. Leese T, West KP, Mortin DB. Fresh forzen plasma in acute pancreatitis: an experimental study. Int J Pancreatol. 1988;3:437–47.

    PubMed  CAS  Google Scholar 

  83. Baillargeon JD, Orav J, Ramagopal V, Tenner SM, Banks PA. Hemoconcentration as an early risk factor for necrotizing pancreatitis. Am J Gastroenterol. 1998;93:2130–4.

    PubMed  CAS  Google Scholar 

  84. Gardner TB, Olenec CA, Chertoff JD, Mackenzie TA, Robertson DJ. Hemoconcentration and pancreatic necrosis: further defining the relationship. Pancreas. 2006;33:169–73.

    PubMed  Google Scholar 

  85. Lankisch PG, Mahlke R, Blum T, Bruns A, Bruns D, Maisonneuve P, et al. Hemoconcentration: an early marker of severe and/or necrotizing pancreatitis? A critical appraisal. Am J Gastroenterol. 2001;96:2081–5.

    PubMed  CAS  Google Scholar 

  86. Gan SI, Romagnuolo J. Admission hematocrit: a simple, useful and early predictor of severe pancreatitis. Dig Dis Sci. 2004;49:1946–52.

    PubMed  Google Scholar 

  87. Brown A, Orav J, Banks PA. Hemoconcentration is an early marker for organ failure and necrotizing pancreatitis. Pancreas. 2000;20:367–72.

    PubMed  CAS  Google Scholar 

  88. Brown A, Baillargeon JD, Hughes MD, Banks PA. Can fluid resuscitation prevent pancreatic necrosis in severe acute pancreatitis? Pancreatology. 2002;2:104–7.

    PubMed  CAS  Google Scholar 

  89. Bardarian A, Shah T, Li JJ, et al. Initial intravenous hydration in acute pancreatitis contributing to unchanged morality 1994 and 2004. Am J Gastroenterol. 2005;100:S714.

    Google Scholar 

  90. Eckerwall G, Olin H, Andersson B, Andersson R. Fluid resuscitation and nutritional support during severe acute pancreatitis in the past: what have we learned and how can we do better? Clin Nutr. 2006;25:497–504.

    PubMed  Google Scholar 

  91. Mao EQ, Tang YQ, Li L, Qin S, Wu J, Liu W, et al. Strategy of controlling fluid resuscitation for severe acute pancreatitis in acute phase. Zhonghua Wai Ke Za Zhi. 2007;45:1331–4.

    PubMed  Google Scholar 

  92. de Madaria E, Soler-Sala G, Sánchez-Payá J, Lopez-Font I, Martínez J, Gómez-Escolar L, et al. Influence of fluid therapy on the prognosis of acute pancreatitis: a prospective cohort study. Am J Gastroenterol. 2011;106(10):1843–50.

    Google Scholar 

  93. Wang ZF, Liu C, Lu Y, Dong R, Xu J, Yu L, et al. Dexamethasone and dextran 40 treatment of 32 patients with severe acute pancreatitis. World J Gastroenterol. 2004;10(9):1333–6.

    PubMed  CAS  Google Scholar 

  94. Wu BU, Hwang JQ, Gardner TB, Repas K, Delee R, Yu S, et al. Lactated Ringer’s solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol. 2011;9(8):710–7.

    PubMed  Google Scholar 

  95. Warndorf MG, Kurtzman JT, Bartel MJ, Cox M, Mackenzie T, Robinson S, et al. Early fluid resuscitation reduces morbidity among patients with acute pancreatitis. Clin Gastroenterol Hepatol. 2011; 9(8):705–9.

    PubMed  PubMed Central  Google Scholar 

  96. Mao EQ, Fei J, Peng YB, Huang J, Tang YQ, Zhang SD. Rapid hemodilution is associated with increased sepsis and mortality among patients with severe acute pancreatitis. Chin Med J. 2010;123(13): 1639–44.

    PubMed  CAS  Google Scholar 

  97. de-Madaria E, Banks PA, Moya-Hoyo N, Wu BU, Rey-Riveiro M, Acevedo-Piedra NG, et al. Early factors associated with fluid sequestration and outcomes of patients with acute pancreatitis. Clin Gastroenterol Hepatol 2013 Oct 29 [epub ahead of print]

    Google Scholar 

  98. Tenner S, Baillie J, DeWitt J, Vege SS, American College of Gastroenterology. American college of gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2013;108:1400–15.

    PubMed  CAS  Google Scholar 

  99. Talukdar R, Vege S. Early management of severe acute pancreatitis. Curr Gastroenterol Rep. 2011; 13(2):123–30.

    PubMed  Google Scholar 

  100. Forsmark CE, Baillie J. AGA institute technical review on acute pancreatitis. Gastroenterology. 1997;132:2022–44.

    Google Scholar 

  101. Whitcomb DC. Clinical practice: acute pancreatitis. N Engl J Med. 2006;354:2142–50.

    PubMed  Google Scholar 

  102. Vege SS, Chari ST, Clain JE. Severe acute pancreatitis. JAMA. 2004;291:2865–8.

    Google Scholar 

  103. Wall I, Badalov N, Baradarian R, Iswara K, Li JJ, Tenner S. Decreased mortality in acute pancreatitis related to early aggressive hydration. Pancreas. 2011;30:547–50.

    Google Scholar 

  104. Gardner TB, Vege SS, Chari ST, Petersen BT, Topazian MD, Clain JE, et al. Faster rate of initial fluid resuscitation in severe acute pancreatitis diminishes in-hospital mortality. Pancreatology. 2009;9:770–6.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, 03766, USA

    Kartik Sampath M.D.

  2. Geisel School of Medicine at Dartmouth, Hanover, NH, USA

    Timothy B. Gardner M.D., M.S.

  3. Section of Gastroenterology, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, 03766, USA

    Timothy B. Gardner M.D., M.S.

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  1. Kartik Sampath M.D.
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Correspondence to Timothy B. Gardner M.D., M.S. .

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Editors and Affiliations

  1. Division of Gastroenterology Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA

    Chris E. Forsmark

  2. Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth Pancreatic Autoislet Cell Program, Lebanon, New Hampshire, USA

    Timothy B. Gardner

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Sampath, K., Gardner, T.B. (2015). Fluid Resuscitation in Acute Pancreatitis. In: Forsmark, C., Gardner, T. (eds) Prediction and Management of Severe Acute Pancreatitis. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0971-1_8

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