Sterile and Infected Pancreatic Necrosis

  • Elham Afghani
  • Vikesh K. SinghEmail author


Acute necrotizing pancreatitis is a complication of acute pancreatitis that carries high morbidity and mortality. The majority of patients have sterile necrosis, which can be managed conservatively. However, in contrast, patients with infected necrosis often require drainage or debridement. Two decades ago, open surgical necrosectomy was the drainage modality of choice but this has largely been replaced by minimally invasive techniques. There have been, controverssies over the use of prophylactic antibiotics to prevent infected necrosis and percutaneous aspiration of necrosis to diagnose infection. This chapter provides an overview of the diagnosis and management of necrotizing pancreatitis. The changes in terminology based on the revised Atlanta classification, current guidelines, as well as the evaluation and management of sterile and infected pancreatic necrosis are discussed in detail.


Acute Pancreatitis Severe Acute Pancreatitis Percutaneous Drainage Pancreatic Necrosis Necrotizing Pancreatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of GastroenterologyJohns Hopkins HospitalBaltimoreUSA
  2. 2.Division of GastroenterologyPancreatic islet autotransplantation programBaltimoreUSA

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