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Lymphohistiocytic and Granulomatous Dermatitis

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Cutaneous Hematopathology

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Abstract

Reactive histiocytic infiltrates presenting in the skin are often admixed with variable collection of lymphocytes, just as certain cutaneous lymphomas may contain histiocytic clusters or frank granulomas. In addition, some lymphohistiocytic dermatitides may be associated with lymphadenopathy and systemic symptoms, frequently raising a concern for lymphoma. Familiarity with the clinical and histologic features delineating reactive from malignant lymphohistiocytic disorders is therefore important to prevent misdiagnosis and subsequent wrong management. In this chapter, the cutaneous lesions of Kikuchi-Fujimoto disease, Rosai-Dorfman disease, sarcoidosis, and granuloma annulare are presented with emphasis on salient clinical presentations, histologic features, immunophenotypes, and differential diagnoses. While the clinical appearance of these lesions may overlap, characteristic microscopic findings allow histopathologic distinction. In addition, their possible etiologic factors, genetic predisposition, clinical associations, and natural courses are also discussed.

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Authors and Affiliations

  1. Departments of Pathology and Dermatology, University of Michigan Health System, 1301 Catherine Street, Medical Science I, M3261, Ann Arbor, MI, 48109, USA

    May P. Chan MD

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  1. May P. Chan MD
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Editors and Affiliations

  1. Department of Hematopathology, IHCFLOW Diagnostic Laboratory, Lutz, Florida, USA

    Hernani D. Cualing

  2. Department of Dermatology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island, USA

    Marshall E. Kadin

  3. Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    Mai P. Hoang

  4. Pensacola and Atlanta Dermpath Diagnostics, University of South Florida College of Medicine, Tampa, Florida, USA

    Michael B. Morgan

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Chan, M.P. (2014). Lymphohistiocytic and Granulomatous Dermatitis. In: Cualing, H., Kadin, M., Hoang, M., Morgan, M. (eds) Cutaneous Hematopathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0950-6_13

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