Dicrocoeliidae Family: Major Species Causing Veterinary Diseases

  • M. Yolanda Manga-GonzálezEmail author
  • M. Carmen Ferreras
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 766)


This chapter analyzes the taxonomic position of Dicrocoeliidae family and several of its genus and species. The biology of the major species causing veterinary diseases such as Dicrocoelium dendriticum, Dicrocoelium hospes, Dicrocoelium chinensis, Eurytrema pancreaticum and Platynosomum fastosum, has been reviewed. All these species have an indirect life cycle, involving two intermediate hosts (molluscs as first and ants, grasshoppers and lizards as second). Dicrocoelium dendriticum is a very widespread hepatic trematode in the ruminants of many countries in Europe, Asia, North Africa and North America, even affecting humans. Dicrocoelium hospes is widely distributed in the savanna areas of Africa south of the Sahara, while D. chinensis has mainly been found in ruminants in East Asia and some European countries (probably imported from Asia). Eurytrema pancreaticum is a common parasite whose adults live in ruminant bile ducts, gall bladder, pancreatic ducts and intestines in Europe, Madagascar, Asia and South America. Adult P. fastosum live in the liver, gall bladder and pancreas of birds and mammals in Europe, Africa, Asia, North, Central and South America. Information about the epidemiology, pathology, clinical aspect, diagnosis, treatment, control, prevention and economic impact mainly of Dicrocoeliosis produced by D. dendriticum, as well as of Eurytrematodosis and Platynosomiosis has been included.


Bile Duct Gall Bladder Intermediate Host Definitive Host Ventral Sucker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Pojmanska T (2008) Family Dicrocoeliidae Looss, 1899. In: Bray RA, Gibson DI, Jones A (eds) Keys to the Trematoda, vol 3. CAB, LondonGoogle Scholar
  2. 2.
    Yamaguti S (1958) Systema Helminthum, vol I, Digenetic trematodes of vertebrates. Interscience, New YorkGoogle Scholar
  3. 3.
    Dawes B (1968) The Trematoda. Cambridge University Press, CambridgeGoogle Scholar
  4. 4.
    Panin VY (1971) A new trematode Suborder, Dicrocoeliata n. suborder. Izvest Akad Nauk Kazak SSR 6:60–66, In: Helminth Abstr (1974), 44:270Google Scholar
  5. 5.
    Mehlhorn H, Walldorf V (1988) Life cycles. In: Mehlhorn H (ed) Parasitology in focus: facts and trends. Springer, BerlinGoogle Scholar
  6. 6.
    Fauna Europaea (2012) Fauna Europaea version 2.5 web service. Available on line at http:
  7. 7.
    Travassos L (1944) Revisao da Familia Dicrocoeliidae Odhner, 1910. Monografías do Instituto Oswaldo Cruz, 2: vii+357 ppGoogle Scholar
  8. 8.
    Panin VY (1981) [Principles of the taxonomy and the system of trematodes of the family Dicrocoeliidae Odhner, 1911]. Nauka 123–133Google Scholar
  9. 9.
    Agrawal SC, Sharma SK (1990) On a new trematode: Neodicrocoeliinae subf. n., Neodicrocoelium gayaparsadai gen. n. et sp. n. (Trematoda, Dicrocoeliidae) from the airbreathing fish, Channa marulius (Ham.) from Jhansi (India). Helminthologia 27:91–98Google Scholar
  10. 10.
    Mapes CR (1951) Studies on the biology of Dicrocoelium dendriticum (Rudolphi, 1819) Loos, 1899 (Trematoda, Dicrocoeliidae), including its relation to the intermediate host, Cionella lubrica (Müller). I. A study of Dicrocoelium dendriticum and Dicrocoelium infection. Cornell Vet 41:382–432PubMedGoogle Scholar
  11. 11.
    Soulsby EJL (1982) Helminths, Arthropods and Protozoa of domesticated animals, 7th edn. Baillère Tindal, LondonGoogle Scholar
  12. 12.
    Malek EA (1980) Snail-transmitted parasitic diseases, vol I & II. CRC, Boca RatonGoogle Scholar
  13. 13.
    Otranto D, Traversa D (2002) A review of dicrocoeliosis of ruminants including recent advances in the diagnosis and treatment. Vet Parasitol 107:317–335PubMedGoogle Scholar
  14. 14.
    Otranto D, Traversa D (2003) Dicrocoeliosis of ruminants: a little known fluke disease. Trends Parasitol 19:12–15PubMedGoogle Scholar
  15. 15.
    Manga-González MY, González-Lanza C (2005) Field and experimental studies on Dicrocoelium dendriticum and dicrocoeliosis in northern Spain. J Helminthol 79:291–302PubMedGoogle Scholar
  16. 16.
    Schuster R (1987) Ein geschichtlicher Überblick zur Namensgebung des Lanzettegels Dicrocoelium dendriticum. Angew Parasitol 28:205–206PubMedGoogle Scholar
  17. 17.
    Odhner T (1910) Dicrocoelium dendriticum (Rud.) der “richtige” Name des kleinen Leberegels. Zool Anz 35:317–318Google Scholar
  18. 18.
    Manga-González MY, González-Lanza C, Cabanas E et al (2001) Contributions to and review of dicrocoeliosis, with special reference to the intermediate hosts of Dicrocoelium dendriticum. Parasitology 123:S91–S114PubMedGoogle Scholar
  19. 19.
    Krull WH, Mapes CR (1952) Studies on the biology of Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 (Trematoda: Dicrocoeliidae), including its relation to the intermediate host, Cionella lubrica (Müller). VII. The second intermediate host of Dicrocoelium dendriticum. Cornell Vet 42:603–604PubMedGoogle Scholar
  20. 20.
    Krull WH, Mapes CR (1953) Studies on the biology of Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 (Trematoda: Dicrocoeliidae), including its relation to the intermediate host, Cionella lubrica (Müller). IX. Notes on the cyst, metacercaria, and infection in the ant, Formica fusca. Cornell Vet 43:389–410PubMedGoogle Scholar
  21. 21.
    Del-Rio J (1967) Epizootiología de la dicroceliosis en la provincia de León. An Fac Vet León 13:211–253Google Scholar
  22. 22.
    Moulinié JJ (1856) De la reproduction chez les trématodes endoparasites. Mém Inst Nat Gen 3:31–44Google Scholar
  23. 23.
    Von Willemoes-Suhm R (1871) Zur Entwicklungsgeschichte des kleinen Leberegels. Z Wiss Zool 21:175–179Google Scholar
  24. 24.
    Leuckart R (1886-1901) Die Parasiten des Menschen und die von ihnen herrührenden Krankheiten. Leipzig: C.F. Winter Bd. 1, Abt. 2:379–399Google Scholar
  25. 25.
    Henkel H (1931) Untersuchungen zur Ermittlung des Zwischenwirtes von Dicrocoelium lanceatum. Z Parasitenkd 3:664–712Google Scholar
  26. 26.
    Piana P (1882) Le cercarie nei molluschi studiate in rapporto colla presenza del Distoma epatico e del Distoma lanceolato nel fegato del ruminanti domestici. Clin Vet 5:306–314Google Scholar
  27. 27.
    Von Linstow D (1887) Helminthologische Untersuchungen, Cercaria vitrina n.sp. Zool Jahrb Syst 3:105–106Google Scholar
  28. 28.
    Nöller W (1929) Befunde bei Schnecken von Thüringer Schafweiden in einem Lanzettegelgebiete. Tierärztliche Rundschau 35:485–489Google Scholar
  29. 29.
    Vogel H (1929) Beobachtungen über Cercaria vitrina und deren Beziehung zum Lanzettegelproblem. Arch Schiffs Tropen Hyg 33:474–489Google Scholar
  30. 30.
    Zarnik B (1910) Über den Entwicklungszyklus von Dicrocoelium lanceatum (Distomum lanceolatum). Sitzungsberichte der Physikalisch-medizini-schen Gesellschaft zu Würzburg 2:27–31Google Scholar
  31. 31.
    Neuhaus W (1936) Untersuchungen über bau und entwicklung der Lanzettegel-Cercarie (Cercaria vitrina) und Klarstellung des infektionsvorganges beim endwirt. Z Parasitenkd 8:431–473Google Scholar
  32. 32.
    Nöller W (1932) Über die Rolle der Wildkaninchen als Lanzettegelträger in einem Thüringer Lanzettegelbiete. Tierärztliche Rundschau 38:190–191Google Scholar
  33. 33.
    Mattes O (1936) Der Entwicklungsgang des Lanzettegels Dicrocoelium lanceolatum. Z Parasitenkd 8:371–430Google Scholar
  34. 34.
    Neuhaus W (1938) Die Invasiosnswege der Lanzettegelcercarie bei der Infektion des Endwirtes und ihre Entwicklung zum Dicrocoelium lanceatum. Z Parasitenkd 10:476–512Google Scholar
  35. 35.
    Krull WH, Mapes CR (1952) Studies on the biology of Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 (Trematoda: Dicrocoeliidae), including its relation to the intermediate host, Cionella lubrica Müller). III. Observations on the slimeballs of Dicrocoelium dendriticum. Cornell Vet 42:253–276PubMedGoogle Scholar
  36. 36.
    Krull WH, Mapes CR (1952) Studies on the biology of Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 (Trematoda: Dicrocoeliidae), including its relation to the intermediate host, Cionella lubrica (Müller). IV. Infection experiments involving definitive hosts. Cornell Vet 42:277–285PubMedGoogle Scholar
  37. 37.
    Vogel H, Falcao J (1954) Über den Lebenszyklus des Lanzettegels, Dicrocoelium dendriticum, in Deutschland. Z Tropenmed Parasit 5:275–296Google Scholar
  38. 38.
    Manga-González MY (1999) Trematodos. In: Cordero-del-Campillo M et al (eds) Parasitología veterinaria. McGraw-Hill Interamericana, MadridGoogle Scholar
  39. 39.
    Manga-González MY, Quiroz-Romero H (1999) Dicroceliosis. In: Cordero-del-Campillo M et al (eds) Parasitología veterinaria. McGraw-Hill. Interamericana, MadridGoogle Scholar
  40. 40.
    Campo R, Manga-González MY, González-Lanza C (2000) Relationship between egg output and parasitic burden in lambs experimentally infected with different doses of Dicrocoelium dendriticum (Digenea). Vet Parasitol 87:139–149PubMedGoogle Scholar
  41. 41.
    Sandoval H, Manga-González MY, Castro JM (2013) A tool for diagnosis of Dicrocoelium dendriticum infection: hatching eggs and molecular identification of the miracidium. Parasitol Res 112:1589–1595PubMedGoogle Scholar
  42. 42.
    Timon-David J (1965) Infestation expérimentale d’une hélicelle par huit espèces de trématodes digénétiques appartenant à quatre familles différentes. Ann Parasit Hum Comp 40:149–154Google Scholar
  43. 43.
    Ractliffe LH (1968) Hatching of Dicrocoelium lanceolatum Eggs. Exp Parasitol 23:67–78PubMedGoogle Scholar
  44. 44.
    Mitterer KE (1975) Untersuchungen zum Schlüpfen der Miracidien des Kleinen Leberegels Dicrocoelium dendriticum. Z Parasitenkd 48:35–45PubMedGoogle Scholar
  45. 45.
    Denev I, Savova S, Stoimenov K et al (1970) An investigation into the dicrocoeliosis in north-eastern Bulgaria. II. On the intermediary and additional hosts of Dicrocoelium lanceatum (Stiles et Hassal, 1896). VetMed Nauki 7:23–31Google Scholar
  46. 46.
    Alunda JM, Rojo-Vázquez FA (1984) Some new molluscan hosts of Dicrocoelium dendriticum in Spain. Ann Parasit Hum Comp 59:57–62Google Scholar
  47. 47.
    Schuster R (1992) Zur Beeinflussung von Helicella obvia durch Dicrocoelium Parthenitae. Angew Parasitol 33:61–64PubMedGoogle Scholar
  48. 48.
    Manga-González MY (1987) Some aspects of the biology and helminthofaune of Helicella (Helicella) itala (Linnaeus, 1758) (Mollusca). Natural infection by Dicrocoeliidae (Trematoda). Rev Ibér Parasitol Vol extr: 131–148.Google Scholar
  49. 49.
    Svadzhyan PK (1951) Contribution to the study of the snails serving as intermediate hosts of Dicrocoelium lanceatum. Izvest Akad Nauk Armyanskoi SSR 4:649–656Google Scholar
  50. 50.
    Tarry DW (1969) Dicrocoelium dendriticum: the life cycle in Britain. J Helminthol 43:403–416Google Scholar
  51. 51.
    González-Lanza C, Manga-González MY, Campo R et al (1997) Larval development of Dicrocoelium dendriticum in Cernuella (Xeromagna) cespitum arigonis under controlled laboratory conditions. J Helminthol 71:311–317PubMedGoogle Scholar
  52. 52.
    Alzieu JP, Ducos De Lahitte J (1991) La dicrocoeliose chez les bovins. Bull GTV 6:135–146Google Scholar
  53. 53.
    Schuster R (1991) Factors influencing the metacercarial intensity in ants and the size of Dicrocoelium dendriticum metacercarial cyst. J Helminthol 65:275–279PubMedGoogle Scholar
  54. 54.
    Martínez-Ibeas AM, Martínez-Valladares M, González-Lanza C et al (2011) Detection of Dicrocoelium dendriticum larval stages in mollusc and ant intermediate hosts by PCR, using mitochondrial and ribosomal internal transcribed spacer (ITS-2) sequences. Parasitology 138:1916–1923PubMedGoogle Scholar
  55. 55.
    Hohorst W, Graefe G (1961) Ameisen-obligatorische Zwischenwirte des Lanzettegels (Dicrocoelium dendriticum), vol 48. Naturwissenschaften, Berlin, pp 229–230Google Scholar
  56. 56.
    Hohorst W (1962) Die rolle der Ameisen im Entwicklungsgang des Lanzettegels (Dicrocoelium dendriticum). Z Tropenmed Parasit 13:377–397Google Scholar
  57. 57.
    Roming T, Lucius R, Frank W (1980) Cerebral larvae in the second intermediate host of Dicrocoelium dendriticum (Rudolphi, 1819) and Dicrocoelium hospes Looss, 1907 (Trematodes, Dicrocoeliidae). Z Parasitenkd 63:277–286Google Scholar
  58. 58.
    Pegreffi G (1957) La distomatosi epatica da Dicrocoelium dendriticum. Vet Ital 8:123–135Google Scholar
  59. 59.
    Hohorst W, Lämmler G (1962) Experimentelle Dicrocoeliose-Studien. Z Tropenmed Parasit 3:377–397Google Scholar
  60. 60.
    Schneider J (1971) Die Wanderung der Metacercarien von Dicrocoelium dendriticum (Rud. 1819), Looss, 1899 (Digenea, Trematoda) im Ameisen Zwischen wirt und ihre Steuerung durch physiologisch-ökologische Faktoren. Inaügural Dissertation Naturwiss. Fakultat der Johaim Wolfgang for the Universita, Frankfurt/MGoogle Scholar
  61. 61.
    Schneider G, Hohorst W (1971) Wanderung der Metacercarien des Lanzett-Egels in Ameisen. Naturwissenschaften 58:327–328PubMedGoogle Scholar
  62. 62.
    Kalkan A (1976) Dicrocoelium dendriticum in Turkey. 2. Observations on second intermediate hosts (ants) in the South Marmara Region. Etlik Vet Bakt Enst Derg 4:11–37Google Scholar
  63. 63.
    Srivastava GC (1975) The intensity of infection in naturally infected Formica pratensis with the metacercariae of Dicrocoelium dendriticum in relation to their size. J Helminthol 49:57–64Google Scholar
  64. 64.
    Paraschivescu D (1981) Etho-ökologische Untersuchungen an einigen Formiciden-Arten als Zwischenwirte von Dicrocoelium dendriticum. Waldhygiene 14:65–72Google Scholar
  65. 65.
    Grigoryan GA (1896) Akopyan VD (1960) [Experimental data on the biology of Dicrocoelium lanceolatum Stiles & Hassall. Trudi Armyanskogo Nauchno-Issledovatelskogo Instituta Zhivotnovodstva i Veterinarii 4:247–254Google Scholar
  66. 66.
    Svadzhyan PK (1960) The development of metacercariae of Dicrocoelium dendriticum in the second intermediate host- the ant. Zool Zh 39:1568–1571Google Scholar
  67. 67.
    Groschaft J (1961) Mravenci doplnkoví mezihostitelé motolice (Dicrocoelium dendriticum Rudolphi 1819). Ceskos Parasitol 8:151–165Google Scholar
  68. 68.
    Timon-David J (1962) Fourmis et “Petite Douve”. Nouvelle découvertes et progrès de la question. L’Entomologiste 18:69–72Google Scholar
  69. 69.
    Krull WH (1958) The migratory route of the metacercaria of Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 in the definitive host: Dicrocoeliidae. Cornell Vet 48:17–24PubMedGoogle Scholar
  70. 70.
    Svadzhyan PK (1959) Puti migracii metacerkarii Dicrocoelium lanceatum Stiles et Hassall, 1896 v organizme okonchatel’nogo joziaina. Veterinariya 36:45–48Google Scholar
  71. 71.
    Srivastava GC, Kolev G, Georgiev M (1978) A surgical approach to trace the route of migration of Dicrocoelium dendriticum in the laboratory animals. Riv Parassit 39:131–137Google Scholar
  72. 72.
    Polozhentseva AA (1968) Observations of Dicrocoelium in the hepatic veins of sheep. Veterinariya (Moscow) 45:59–60Google Scholar
  73. 73.
    Chandra G (1973) First detection of Dicrocoelium eggs in the faeces of experimentally infected lambs, guinea pigs and pigs. HAU J Res 3:31–34Google Scholar
  74. 74.
    Macko JK, Pacenovsky J (1987) On the variability of Dicrocoelium dendriticum (Rudolphi, 1819) in domestic and free-living animals. II. On individual variability of the cattle (Bos taurus -race locale) dicrocoeliids in Algeria. Helminthologia 24:111–118Google Scholar
  75. 75.
    Bourgat R, Séguin D, Bayssade-Dufour C (1975) Données nouvelles sur Dicrocoelium hospes Looss, 1907: Anatomie de l’adulte et cycle évolutif. Ann Parasit Hum Comp 50:701–714Google Scholar
  76. 76.
    Kajubiri V, Hohorst W (1977) Increasing incidence of Dicrocoelium hospes (LOOSS, 1907) (Trematoda: Digenea) in Uganda. J Helminthol 51:212–214PubMedGoogle Scholar
  77. 77.
    Lucius R, Frank W (1978) Beitrag zur Biologie von Dicrocoelium hospes Looss, 1907 (Trematodes, Dicrocoeliidae). Acta Trop 35:161–181PubMedGoogle Scholar
  78. 78.
    Malek EA (1980) Ocurrence of Dicrocoelium hospes in Mali and Senegal, West Africa. J Helminthol 54:45–46PubMedGoogle Scholar
  79. 79.
    Lucius R (1981) Untersuchungen zur Biologie, Pathologie und Ökologie von Dicrocoelium hospes Looss, 1907 (Trematode, Dicrocoeliidae). Dissertation zur Erlangung des Grades eines Doktors der Naturwissenschaften vorgelegt der Fakultät II (Biologie) der Universität HohenheimGoogle Scholar
  80. 80.
    Fashuyi SA, Adeoye GO (1986) The possible snail intermediate hosts of Dicrocoelium hospes in Nigeria. Acta Vet Brno 55:85–88Google Scholar
  81. 81.
    Maurelli MP, Rinaldi L, Capuano F et al (2007) Characterization of the 28S and the second internal transcribed spacer of ribosomal DNA of Dicrocoelium dendriticum and Dicrocoelium hospes. Parasitol Res 101:1251–1255PubMedGoogle Scholar
  82. 82.
    Sudarikov VE, Ryjikov KM (1951) On the helminth fauna of ungulates of the Baikal region. Trudy Gel’mintol Lab Akad Nauk SSSR 5:53–58Google Scholar
  83. 83.
    Tang C, Tang Z, Tang L et al (1983) Studies on the biology and epizooties of Dicrocoelium chinensis in the eastern Inner Mongol Autonomous region. Acta Zool Sin 29:340–349Google Scholar
  84. 84.
    Tang C, Tang L, Wang F et al (1985) Investigations on the biology of a few Dicrocoelium species of sheep on Qinghai Plateau. Acta Zool Sin 31:245–262Google Scholar
  85. 85.
    Taira K, Shirasaka S, Taira N et al (2006) Morphometry on lancet flukes found in Japanese sika deer (Cervus nippon centralis) captured in Iwate Prefecture, Japan. J Vet Med Sci 68:375–377PubMedGoogle Scholar
  86. 86.
    Hinaidy HK (1983) Dicrocoelium suppereri nomen novum (syn. D. orientalis Sudarikov et Ryjikov 1951), a new trematode for the parasite fauna of Austria. Zentralbl Veterinarmed B 30:576–589PubMedGoogle Scholar
  87. 87.
    Poglayen G, Roda R, Tona A et al (1996) Endoparasites of the muflon (Ovis ammon musimon) from the Belluno province, Italy. Ric Biol Selvaggina 24:73–77Google Scholar
  88. 88.
    Otranto D, Rehbein S, Weigl S et al (2007) Morphological and molecular differentiation between Dicrocoelium dendriticum (Rudolphi, 1819) and Dicrocoelium chinensis (Sudarikov and Ryjikov, 1951) Tang and Tang, 1978 (Platyhelminthes: Digenea). Acta Trop 104:91–98PubMedGoogle Scholar
  89. 89.
    Gu JT, Liu RK, Li QF et al (1990) Epidemiological survey on Eurytrema pancreaticum and Dicrocoelium chinensis in sheep in the southern area of Daxinganling Mountain of Inner Mongolia. Chin J Vet Sci Technol 3:15–16Google Scholar
  90. 90.
    Manga-González MY, Quiroz-Romero H, González-Lanza C et al (2010) Strategic control of Dicrocoelium dendriticum (Digenea) egg excretion by naturally infected sheep. Vet Med 55:19–29Google Scholar
  91. 91.
    Manga-González MY, González-Lanza C, Del-Pozo-Carnero P (1991) Dynamics of the elimination of Dicrocoelium dendriticum (Trematoda, Digenea) eggs in the faeces of lambs and ewes in the Porma Basin (León, NW Spain). Ann Parasit Hum Comp 66:57–61Google Scholar
  92. 92.
    Manga-González MY, González-Lanza C, Cabanas E (2007) Dicrocoelium dendriticum primoinfection and kinetic egg elimination in marked lambs and ewes from León mountains (Spain). Rev Iber Parasitol 67:15–25Google Scholar
  93. 93.
    Sadykhov IA, Melikov YF (1980) (Features of the distribution of Fasciola and Dicrocoelium in farming complexes in the Sheki-Zakataly area of the Azerbaidzhan SSR). Izvest Akad Nauk Azerbaidzhan SSR, Biol Nauki 3:75–79, In: Helm Abstr (1981), 50:5810Google Scholar
  94. 94.
    Pavlov P, Popov A, Bankov D et al (1965) Untersuchungen über die Wirksamkeit von Hetolin® bei der Infektion der Schafe mit Dicrocoelium lanceolatum. Tierarztl Umsch 20:574–575Google Scholar
  95. 95.
    Tang C, Tang Z, Qi P et al (1981) [Studies on the biology of Dicrocoelium lanceatum in Xin Jiang Autonomous region]. Acta Zool Sin 27:265–273, In: Helm Abstr (1982), 51:4603Google Scholar
  96. 96.
    Calamel M (1976) La dicrocoeliose ovine et caprine dans le Sud-Est de la France. Rev Med Vet 127:1529–1536Google Scholar
  97. 97.
    Liakos DV (1985) Epidemiological survey of parasitoses of sheep and goats. Etlen Kteniat Hellen Vet Med 28:271–278Google Scholar
  98. 98.
    Ambrosi M, Principato M (1981) Dicroceliosi ovina: variazioni stagionali della positività coproscopica in animali spontaneamente parassitati. Ob Doc Vet 2:55–56Google Scholar
  99. 99.
    Quesada A, Russillo A, Rosa P et al (1991) Diffusione di F. hepatica e D. dendriticum in greggi ovini allevati in un distretto alto-collinare delle Basilicata. Acta Med Vet 37:295–304Google Scholar
  100. 100.
    Angelovski T, Iliev A, Madzirov Z (1970) Nasi noviji rezultati istrazivanja epizootiologije dikrocelioze u ovaca. Vet Glasnik 24:995–999, En: Helm Abstr 42:1126Google Scholar
  101. 101.
    Vershinin II (1957) Epizootiology of Dicrocoelium infections of sheep and its biology in the Kaluga region. Tr Moskov Vet Akad 19:3–15Google Scholar
  102. 102.
    Uriarte J, Cabaret J, Tanco JA (1985) The distribution and abundance of parasitic infections in sheep grazing on irrigated or non-irrigated pastures in north-eastern Spain”. Ann Rech Vét 16:321–325PubMedGoogle Scholar
  103. 103.
    Kalkan A (1971) Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 in Turkey. l. Field studies of intermediate and final hosts in the South Marmara region, 1968. Br Vet J 127:67–75PubMedGoogle Scholar
  104. 104.
    Al-Khalidi NW, Al-Bayati MMA (1989) The epidemiology of dicrocoeliasis in sheep in Mosul (Iraq). J Vet Parasitol 3:21–23Google Scholar
  105. 105.
    González-Lanza C, Manga-González MY, Del-Pozo P (1993) Coprological study of the Dicrocoelium dendriticum (Digenea) egg elimination by cattle in highland areas in León Province, Northwest Spain. Parasitol Res 79:488–491PubMedGoogle Scholar
  106. 106.
    Denev I, Stoimenov K, Donev A et al (1970) Dicrocoeliasis in north-eastern Bulgaria. I. Geographical and seasonal incidence. Vet Med Nauki Sofia 7:21–29Google Scholar
  107. 107.
    Batelli G, Poglayen G, Martini M (1987) Indagine sulla diffusione della fascioliasi bovina in provincia di Firenze. Summa 4:45–49Google Scholar
  108. 108.
    Afzal M, Shafique M, Hussain A et al (1981) A study of helminths of cattle and buffaloes in Lahore. Pak J Sci 33:14–20Google Scholar
  109. 109.
    Ben Amer KF, Ahmed Z (1980) Studies on the prevalence of liver flukes with special reference to Dicrocoelium dendriticum (Rudolphi, 1891) Looss 1899 in sheep and cattle from Tripoli region Libya. Riv Parassitol 41:15–18Google Scholar
  110. 110.
    Mañas I, Gómez V, Lozano J et al (1978) Estudio de la frecuencia de la dicroceliosis en el ganado de la provincia de Granada. Rev Iber Parasitol 38:751–773Google Scholar
  111. 111.
    Bailenger J, Tribouley J, Amyot B et al (1965) Importance des Léporides comme réservoirs sauvages dans l’épidemiologie des distomatoses a Fasciola hepatica et Dicrocoelium dendriticum. Ann Parasitol Hum Comp 40:51PubMedGoogle Scholar
  112. 112.
    Blasco S, Feliu C, Torres J et al (1993) Oryctolagus cuniculus (Linnaeus, 1758) hospedador de Dicrocoelium dendriticum (Rudolphi, 1819) en Cataluña. Acta Parasit Port 1(2):171Google Scholar
  113. 113.
    Gutiérrez JF, Castellá J, Muñoz E et al (1993) Parásitos de rumiantes salvajes en Cataluña (NE de España). Acta Parasit Port 1(2):196Google Scholar
  114. 114.
    Bolukbas CS, Gurler AT, Beyhan YE et al (1912) Helminths of roe deer (Capreolus capreolus) in the Middle Black Sea Region of Turkey. Parasit Int 61:729–730Google Scholar
  115. 115.
    Kopp H (1975) Untersuchungen über die Eiausscheidung von Fasciola hepatica und Dicrocoelium dendriticum bei Schaf und Rind im Verlauf eines Jahres. Inaugural-Dissertation zur Erlangung der tiermedizinischen Doktorwürde des Fachbereichs Tiermedizin der Ludwig- Maximillians-Universität, MünchenGoogle Scholar
  116. 116.
    Ershov VS (1964) Textbook of veterinary helminthology. Izdatelstvo Kolos, MoscowGoogle Scholar
  117. 117.
    Boray JC (1985) Flukes of domestic animals. In: Gaafar SM, Howard WE, Marsh RE (eds) Parasites, pests and predators, World animal science. B Disciplinary approach. Elsevier, AmsterdamGoogle Scholar
  118. 118.
    Alunda JM, Rojo-Vázquez FA (1983) Survival and infectivity of Dicrocoelium dendriticum eggs under field conditions in NW Spain. Vet Parasitol 13:245–249PubMedGoogle Scholar
  119. 119.
    Rozman S, Gradjanin M, Cankovic M (1974) The transitory hosts of Dicrocoelium dendriticum in the mountain area of Bosnia and Herzegovina. In: Proceedings of the third international congress of parasitology, August 1974, MunichGoogle Scholar
  120. 120.
    Alunda JM, Manga-González MY (1982) Susceptibility of some species of the genus Helicella Férussac, 1821 (Gastropoda, Helicidae) to the infection by Dicrocoelium dendriticum (Trematoda). Malacologia 22:51–54Google Scholar
  121. 121.
    Boray JC (1982) Molluscan hosts and trematodes. In: Symons LEA, Donald AD, Dineen JK (eds) Biology and Control of Endoparasites. Academic, SydneyGoogle Scholar
  122. 122.
    Manga-González MY (1983) Los Helicidae (Gastropoda, Pulmonata) de la Provincia de León. Institución “Fray Bernardino de Sahagún”, Excma. Diputación Provincial de León, Consejo Superior de Investigaciones Científicas (CECEL), León (España)Google Scholar
  123. 123.
    Bocharova MM (1984) [Zonal distribution of foci of Dicrocoelium infection on the northern slopes of the Central Caucasus and the eastern pre-Caucasus region (USSR)]. Materialy Nauchnoi Konferentsii Vsesoyuznogo Obshchestva Gel’mintologov. Biologiya y taksnomiya gel’mintov zhivotnykh y cheloveka 34:97–105Google Scholar
  124. 124.
    Badie A, Hourdin P, Rondelaud D (1992) L’infestation de Cochlicopa lubrica Müller par Dicrocoelium lanceolatum Rudolphi. A propos de quelques observations histophatologiques. Bull Soc Fr Parasitol 10:51–57Google Scholar
  125. 125.
    Schuster R (1993) Infection patterns in the first intermediate host of Dicrocoelium dendriticum. Vet Parasitol 47:235–243PubMedGoogle Scholar
  126. 126.
    Alunda JM, Rojo-Vázquez FA (1982) Susceptibility of some populations of Cernuella (Xeromagna) cespitum arigonis (Schmidt, 1875) (Gastropoda, Helicidae) from the Douro basin (Iberian Peninsula) to the infection by Dicrocoelium dendriticum (Trematoda). Malacologia 22:39–43Google Scholar
  127. 127.
    Manga-González MY, González-Lanza C, Del-Pozo-Carnero P et al (1995) Studies on experimental infection by Dicrocoelium dendriticum (Trematoda) of Cernuella (Xeromagna) cespitum arigonis (Mollusca) specimens in natural environment. In: Abstracts of 12th Internacional Malacological Congress, Vigo, SpainGoogle Scholar
  128. 128.
    Álvarez-Nogal R, Manga-González MY, González-Lanza C et al (1992) Preliminary study on Dicrocoelium dendriticum (Trematoda) first larval stages in experimentally infected Cernuella (Xeromagna) cespitum arigonis (Mollusca). Abstracts of the VIth European Multicolloquium of Parasitology, The HagueGoogle Scholar
  129. 129.
    Gómez BJ, Manga-González MY, Angulo E et al (1996) Alteraciones histológicas producidas por Dicrocoelium dendriticum (Trematoda) en dos especies de Cernuella (Mollusca) sacrificadas a los tres meses post-infestación. Iberus 14:189–195Google Scholar
  130. 130.
    Alunda JM, Rojo-Vázquez FA (1983) Effect of infection rate and host age on the intramolluscan development of Dicrocoelium dendriticum. Helminthologia 20:251–258Google Scholar
  131. 131.
    Badie A (1978) La dicroceliose ovine: incidence des facteurs climatiques et contribution à la mise au point d’une méthode de prévision. Ann Parasitol Hum Comp 53:373–385PubMedGoogle Scholar
  132. 132.
    Jonlija R, Milka R, Cankovic M (1973) Ispitivanje infestiranosti puzeva y mrava razvojnim oblicima Dicrocoelium lanceatum u Bosni y Hercegovini. l. Veterinaria 22:449–470Google Scholar
  133. 133.
    Paraschivescu D, Hurghisiu L, Popescu S (1976) Bioecologic and biochemical research upon Formicidae complementary hosts of the Dicrocoelium lanceatum fluke (Stiles and Hassall, 1896). Arch Vet 11/12:159–178Google Scholar
  134. 134.
    Loos-Frank B (1978) Zum Verhalten von Ameisen der Gattung Formica (Hymenoptera: Formicidae) gegenüber Schleimballen des Kleinen Leberegels Dicrocoelium dendriticum (Digenea: Dicrocoeliidae) und über infektionsbedingte Veränderungen ihrer Hämolymphe. Entomol Germ 4:12–23Google Scholar
  135. 135.
    Paraschivescu D (1978) Dynamics of formicids (Hym., Formicidae) in tetany of some meadows with dicrocelioza in Romania. Trav Mus Hist Nat “Grigore Antipa” 19:321–323Google Scholar
  136. 136.
    Spindler EM, Zhaler M, Loos-Frank B (1986) Behavioural aspects of ants as second intermediate hosts of Dicrocoelium dendriticum. Z Paransitenkd 72:689–692Google Scholar
  137. 137.
    Jonlija R, Cankovic M, Rozman M (1972) Examination of ants the second intermediary hosts of Dicrocoelium lanceatum in Bosnia and Hercegovina, I. Veterinaria 21:317–322Google Scholar
  138. 138.
    Paraschivescu D (1983) Untersuchungen zur Temperaturabhangigkeit der Tetaniephase von Formica pratensis bei einer Infektion mit Stadien des Kleinen Leberegels Dicrocoelium dendriticum. Waldhygiene 15:21–24Google Scholar
  139. 139.
    Dementev IS, Karabaev DK (1968) (Infection of terrestrial molluscs and ants by Dicrocoelium dendriticum larvae in southeastern Kazakhstan). Velt Sel’-Kho. Nauki 12:51–55Google Scholar
  140. 140.
    Ekstam B, Johansson B, Dinnétz P et al (2011) Predicting rik habitats for the transmission of the small liver fluke, Dicrocoelium dendriticum to grazing ruminants. Geospat Health 6:125–131PubMedGoogle Scholar
  141. 141.
    Rojo-Vázquez FA, Meana A, Valcárcel F et al (2012) Update on trematode infections in sheep. Vet Parasitol 189:15–38PubMedGoogle Scholar
  142. 142.
    Skálová L, Forstová-Křížová V, Civilink V et al (2007) Mouflon (Ovis musimon) dicrocoeliosis: Effects of parasitosis on the activities of biotransformation enzymes and albendazole metabolism in liver. Vet Parasitol 146:254–262PubMedGoogle Scholar
  143. 143.
    Bártíková A, Vokřál I, Forstová-Křížová V et al (2011) The transport of albendazole and albendazole sulphoxide in the lancet fluke (Dicrocoelium dendriticum). Vet Parasitol 176:27–33PubMedGoogle Scholar
  144. 144.
    Wolff K, Hauser B, Wild P (1984) Dicrocoeliose des Schafes: Untersuchungen zur Pathogenese und zur Regeneration des Leber nach Therapie. Berl Münch Tierärztl Wochenschr 97:378–387PubMedGoogle Scholar
  145. 145.
    Rojo-Vázquez FA, Cordero-del-Campillo M, Díez-Baños P et al (1981) Relation existant entre le nombre d’oeufs dans les fèces et la charge parasitaire lors des infestations naturelles a Dicrocoelium dendriticum chez les ovins. Rev Med Vet 132:601–607Google Scholar
  146. 146.
    Sánchez-Andrade R, Paz-Silva A, Suárez JL et al (2003) Serum antibodies to Dicrocoelium dendriticum in sheep from Sardinia (Italy). Prev Vet Med 57:1–5PubMedGoogle Scholar
  147. 147.
    Manga-González MY, Ferreras MC, Campo R et al (2004) Hepatic marker enzymes, biochemical parameters and pathological effects in lambs experimentally infected with Dicrocoelium dendriticum. Parasitol Res 93:344–355PubMedGoogle Scholar
  148. 148.
    Salimova M (1972) (Experimental dicrocoeliasis of Karakul lambs). Trudy VII Vsesoyuznoi Konferentsii po Prirodnoi Ochagovosti Boleznei i Obshchim Voprosam Parazitologii Zhivotnykn, 14-18 Oktyabrya 1969, Samarkand, 6. Tashkent, USSR: Izdatel’stvo “FAN” Uzbekskoi SSR:155-157Google Scholar
  149. 149.
    Sargison ND, Baird GJ, Sotiraki S et al (2012) Hepatogenous photosensitisation in Scottish sheep caused by Dicrocoelium dendriticum. Vet Parasitol 189:233–237PubMedGoogle Scholar
  150. 150.
    Ranucci S, Mughetti L, Ambrosi M et al (1981) Rilievi ematochimici, anatomo-istopatologici e parassitologici in ovini infetti da dicroceliosi. Riv Zoot Vet 9:173–175Google Scholar
  151. 151.
    Sánchez-Campos S, Tuñón MJ, González P et al (1996) Effects of experimental dicrocoeliosis on oxidative drug metabolism in hamster liver. Comp Biochem Physiol 115C:55–60Google Scholar
  152. 152.
    Sánchez-Campos S, Tuñón MJ, González P et al (1999) Oxidative stress and changes in liver antioxidant enzymes induced by experimental dicrocoeliosis in hamsters. Parasitol Res 85:468–474PubMedGoogle Scholar
  153. 153.
    Sánchez-Campos S, González P, Ferreras C et al (2000) Morphologic and biochemical changes caused by experimentally induced dicrocoeliosis in hamsters (Mesocricetus auratus). Comp Med 50:147–152PubMedGoogle Scholar
  154. 154.
    Sánchez-Campos S, Tuñón MJ, González P et al (1998) Enhanced bile formation induced by experimental dicrocoeliosis in the hamster. Life Sci 63:1963–1974PubMedGoogle Scholar
  155. 155.
    Jithendran KP, Bhat TK (1996) Prevalence of dicrocoeliosis in sheep and goats in Himachal Pradesh, India. Vet Parasitol 61:265–271PubMedGoogle Scholar
  156. 156.
    Rahko T (1972) Studies on the pathology of dicrocoeliasis and fascioliasis in the goat. I. The histopathology of the liver and bile ducts. Acta Vet Scand 13:554–562PubMedGoogle Scholar
  157. 157.
    Camara L, Pfister J, Aeschlimann A (1996) Analyse histopathologique de foie de bovin infesté par Dicrocoelium dendriticum. Vet Res 27:87–92PubMedGoogle Scholar
  158. 158.
    Rahko T (1972) Studies on the pathology of dicrocoeliasis and fascioliasis in the goat. II. The histochemistry of bile-duct mucosubstances. Acta Vet Scand 13:563–574PubMedGoogle Scholar
  159. 159.
    Rahko T (1972) Studies on the pathology of dicrocoeliasis and fascioliasis in the goat. III. The histochemistry of mast cells and globule leucocytes. Acta Vet Scand 13:575–584PubMedGoogle Scholar
  160. 160.
    Robinson N, Piedrafita D, Snibson K et al (2010) Immune cell kinetics in the ovine abomasal mucosa following hyperimmunization and challenge with Haemonchus contortus. Vet Res 41:37PubMedCentralPubMedGoogle Scholar
  161. 161.
    Stalker MJ, Hayes MA (2007) Liver and biliary system. In: Maxie GM (ed) Jubb, Kennedy, and Palmer’s pathology of domestic animals, 5th edn. Saunders Elsevier, EdinburghGoogle Scholar
  162. 162.
    Katayama F (1996) Alterations of the mucin components in bile duct epithelium associated with proliferating cholangitis. An experimental study. Hokkaido Igaku Zasshi 71:585–598PubMedGoogle Scholar
  163. 163.
    Mederacke I (2013) Liver fibrosis-Mouse models and relevance in human liver. Z Gastroenterol 51:55–62PubMedGoogle Scholar
  164. 164.
    Prunescu C, Prunescu P, Fromunda V et al (1979) Histopathological changes of the liver in hamsters with experimental dicroceliasis. Arch Vet 14:83–90Google Scholar
  165. 165.
    Katsoulos PD, Christodoulopoulos G, Karatzia M et al (2011) Liver flukes promote cholelithiasis in sheep. Vet Parasitol 179:262–265PubMedGoogle Scholar
  166. 166.
    Dhar DN, Shing KS (1963) Histochemical studies on liver in dicrocoeliasis. Indian J Vet Sci 33:142–151Google Scholar
  167. 167.
    Ferreras MC, Campo R, González-Lanza C et al (2007) Immunohistochemical study of the local immune response in lambs experimentally infected with Dicrocoelium dendriticum (Digenea). Parasitol Res 101:547–555Google Scholar
  168. 168.
    González-Lanza C, Manga-González MY, Campo R et al (2000) IgG antibody response to ES or somatic antigens of Dicrocoelium dendriticum (Trematoda) in experimentally infected sheep. Parasitol Res 86:472–479PubMedGoogle Scholar
  169. 169.
    Braun U, Wolfensberger R, Hertzbrg H (1995) Diagnosis of liver flukes in cows—a comparison of the findings in the liver, in the faeces, and in the bile. Schweiz Arch Tierheilkd 137:438–444PubMedGoogle Scholar
  170. 170.
    Scala A, Coda S, Ximenes LA et al (1991) Dicroceliasi ovina in Sardegna: Tassi di prevalenza, lesioni anatomo-istopatologiche e tests ematochimici. Atti Fe Me S P Rum 1:209–214Google Scholar
  171. 171.
    Rehbein S, Kokott S, Lindner T (1999) Evaluation of thecniques for the enumeration of Dicrocoelium eggs in sheep faeces. Zentralbl Veterinermed A 46:133–139Google Scholar
  172. 172.
    Bode L, Geyer E (1981) Experimental dicrocoeliasis: the humoral immune response of gladden hamsters and rabbits to primary infection with Dicrocoelium dendriticum. Z Parasitenkd 66:167–178PubMedGoogle Scholar
  173. 173.
    Baldelli B, Piergili-Fioretti D, Ambrosi M et al (1981) Dicroceliosi ovina: studio degli anticorpi verso Dicrocoelium dendriticum in agnelli nati da pecore spontaneamente infertte. Riv Parassit 1:23–30Google Scholar
  174. 174.
    Wedrychowicz H, Ducommun D, Bambara OD et al (1997) Local and systematic antibody response against surface, somatic and ES antigens of Dicrocoelium dendriticum in sheep naturally infected with the trematode. Acta Parasitol 42:248–253Google Scholar
  175. 175.
    Şimşek S, Köroğlu E, Ütük AE (2006) Application of Western blotting and enzyme linked immunosorbent assay (ELISA) for the diagnosis of Dicrocoelium dendriticum in sheep using excretory secretory (E/S) antigens. Turk J Vet Anim Sci 30:113–119Google Scholar
  176. 176.
    Fagbemi BO, Obarisiagbon IO (1991) Common antigens of Fasciola gigantica, Dicrocoelium hospes and Schistosoma bovis and their relevante to serology. Vet Quarterly 13:81–87Google Scholar
  177. 177.
    Wedrychowicz H, Ducommun D, Gorski P et al (1995) Somatic antigens of adult Dicrocoelium dendriticum recognized by bile antibodies of naturally infected cattle. Vet Parasitol 56:47–56PubMedGoogle Scholar
  178. 178.
    Colwell DD, Goater CP (2010) Dicrocoelium dendriticum in cattle from Cypress Hills, Canada: humoral response and preliminary evaluation of an ELISA. Vet Parasitol 174:162–165PubMedGoogle Scholar
  179. 179.
    Revilla-Nuín B, Manga-González MY, Miñambres B et al (2005) Partial characterization and isolation of 130 kDa antigenic protein of Dicrocoelium dendriticum adults. Vet Parasitol 134:229–240PubMedGoogle Scholar
  180. 180.
    González-Lanza C, Manga-González MY, Revilla-Nuín B (2006) Preliminary protective capacity study of a Dicrocoelium dendriticum antigenic protein in hamsters. Parasitol Res 99:749–752PubMedGoogle Scholar
  181. 181.
    Campo R, Manga-González MY, González-Lanza C et al (1998) Characterization of adult Dicrocoelium dendriticum by isoelectric focusing. J Helminthol 72:109–116Google Scholar
  182. 182.
    Sandoval H, Manga-González MY, Campo R et al (1999) Preliminary study on genetic variability of Dicrocoelium dendriticum determined by random amplified polymorphic DNA. Parasitol Int 48:21–26PubMedGoogle Scholar
  183. 183.
    Morozova EV, Ryskov AP, Semyenova SK (2002) RAPD variation in two Trematode species (Fasciola hepatica and Dicrocoelium dendriticum) from a single cattle population. Russian J Genetics 38:977–983Google Scholar
  184. 184.
    Bazsalovicsová E, Králová-Hromadová I, Spakulová M et al (2010) Determination of ribosomal internal transcribed spacer 2 (ITS2) interspecific markers in Fasciola hepatica, Fascioloides magna, Dicrocoelium dendriticum and Paramphistomum cervi (Trematoda), parasites of wild and domestic ruminants. Helminthologia 47:76–82Google Scholar
  185. 185.
    Stratan NM (1986) Efficacy of Acemidophen against Dicrocoelium dendriticum in sheep. Byulleten’ Vsesoyuznogo Instituta Gel’mintologii im. K.I. Skryabina 42:64–66Google Scholar
  186. 186.
    Cordero-del-Campillo M, Rojo-Vázquez FA, Díez-Baños P et al (1982) Efficacité de l’albendazole contre une infestation naturelle a Dicrocoelium dendriticum chez le mouton. Rev Méd Vét 133:41–49Google Scholar
  187. 187.
    Himonas CA, Liakos V (1980) Efficacy of albendazole against Dicrocoelium dendriticum in sheep. Vet Rec 197:288–289Google Scholar
  188. 188.
    Corba J, Krupicer I (1992) Efficacy of intraruminal albendazole boluses against Dicrocoelium dendriticum in sheep. Parasit Res 78:640–642Google Scholar
  189. 189.
    Schuster R, Hiepe T (1993) Bekämpfung der Dicrocoeliose beim Schaf. Vet-Med 48:657–661Google Scholar
  190. 190.
    Ambrosi M (1989) Efficacia del tiofanato a dose normale contro Dicrocoelium dendriticum. Il Nuovo Progresso Veterinario 15–16:1–7Google Scholar
  191. 191.
    Ambrosi M, Morettini B, Ranucci S et al (1986) Efficacia della somministrazione orale di tiofanato (1-bis(3-etossicarbonil-2-tioureido)benzene) per la terapia dell’infestione da Dicrocoelium dendriticum negli ovini. Ri Zoot Vet 14:25–31Google Scholar
  192. 192.
    Brugêre-Picoux J, Tafani JP, Chirol C et al (1986) Efficacité du thiophanate sur Dicrocoelium lanceolatum chez le mouton. Rec Méd Vét 162:973–978Google Scholar
  193. 193.
    Corba J, Hovorka J, Spaldonova R et al (1987) Efficacy of luxabendazole (Hoe 216 V) sup. 5 % in sheep naturally infected with the most important helminths. Helminthologia 24:227–235Google Scholar
  194. 194.
    Kassai T, Takats C, Fok E et al (1988) Activity of luxabendazole against liver flukes gastrointestinal roundworm and lungworm in naturally infected sheep. Parasitol Res 75:14–18PubMedGoogle Scholar
  195. 195.
    Sanz F, Tarazona JM, Jurado R et al (1987) An evaluation of the efficacy of netobimin against Dicrocoelium dendriticum in sheep. Vet Rec 17:57–58Google Scholar
  196. 196.
    Corba JA, Krupicer L, Petko B et al (1993) Efficacy of netobimin against liver flukes, gastrointestinal and lungworms in naturally infected sheep. Helminthologia 30:57–61Google Scholar
  197. 197.
    Rojo-Vázquez FA, Meana A, Tarazona JM et al (1989) The efficacy of netobimin, 15 mg/kg, against Dicrocoelium dendriticum in sheep. Vet Rec 124:512–513PubMedGoogle Scholar
  198. 198.
    Ambrosi M, Grenolli V (1991) Prove di campo sull’uso del mebendazole nel poliparassitismo ovino. Ob Doc Vet 12:89–91Google Scholar
  199. 199.
    Lukin AK (1980) The prevalence and economic loss due to dicrocoeliasis in ruminants. Trudy Saratovskoi Nauchno-Issledovatel’skoi veterinamoi Stantsii 14:76–79Google Scholar
  200. 200.
    Karanfilovski G (1983) Economic losses caused by fascioliasis and dicrocoeliasis to livestock production in Pljevlja and surrounding area. Vet Yugoslav 32:253–260Google Scholar
  201. 201.
    Cavani C, Losi G, Manfredini M et al (1982) Ricerche sull’influenza della dicroceliasi sulle caratteristiche quantitative e qualitative della produzione di latte in pecore. Ob Doc Vet 3:59–63Google Scholar
  202. 202.
    Graydon RJ, Carmichael IH, Sánchez MD et al (1992) Mortalities and wasting in Indonesian sheep associated with the trematode Eurytrema pancreaticum. Vet Rec 131:443PubMedGoogle Scholar
  203. 203.
    Ilha MRS, Loretti AP, Reis ACF (2005) Wasting and mortality in beef cattle parasitized by Eurytrema coelomaticum in the State of Paraná, southern Brazil. Vet Parasitol 133:49–60PubMedGoogle Scholar
  204. 204.
    Charles JA (2007) Pancreas. In: Maxie GM (ed) Jubb, Kennedy and Palmer’s pathology of domestic animals, 5th edn. Saunders Elsevier, EdinburghGoogle Scholar
  205. 205.
    Bassani CA, Sangioni LA, Saut JPE et al (2006) Epidemiology of eurytrematosis (Eurytrema spp. Trematoda: Dicrocoeliidae) in slaughtered beef cattle from the central-west region of the State of Paraná, Brazil. Vet Parasitol 141:356–361PubMedGoogle Scholar
  206. 206.
    Ferreira AMR, Almeida ECP, Labarthe NV (1999) Liver fluke infection (Platynosomum concinnum) in Brazilian cats: prevalence and pathology. Feline Pract 27:19–22Google Scholar
  207. 207.
    Andrade RIFS, Dantas AFM, Pimentel LA et al (2012) Platynosomum fastosum-induced cholangiocarcinomas in cats. Vet Parasitol 190:277–280PubMedGoogle Scholar
  208. 208.
    Headley SA, Gillen MA, Sanches AWD et al (2012) Platynosomum fastosum-induced chronic intrahepatic cholangitis and Spirometra spp infections in feral cats from Grand Cayman. J Helminthol 86:209–214Google Scholar
  209. 209.
    Warren KS, Swan RA, Hobbs RP et al (1998) Platynosomum fastosum in ex-captive orangutans from Indonesia. J Wildl Dis 34:644–646PubMedGoogle Scholar
  210. 210.
    Kazacos KR, Dhillon AS, Winterfield RW et al (1980) Fatal hepatic trematodiasis in cockatoos due to Platynosomum proxillicens. Avian Dis 24:788–793PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • M. Yolanda Manga-González
    • 1
    Email author
  • M. Carmen Ferreras
    • 2
  1. 1.Departamento de Sanidad AnimalInstituto de Ganadería de Montaña, Consejo Superior de Investigaciones Científicas (CSIC)—ULELeónSpain
  2. 2.Facultad de Veterinaria, Departamento de Sanidad AnimalUniversidad de León (ULE)LeónSpain

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