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Female Puberty pp 71–78Cite as

Central Precocious Puberty

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Abstract

Background: Central precocious puberty occurs in 0.2 % of young girls and is officially defined as the presence of pubertal signs or characteristics in girls under the age of 7 years. This condition occurs as a result of early activation of the hypothalamic pituitary axis. The most common type is idiopathic, although this is diagnosis of exclusion. Purpose: To alert providers about the warning signs and when to intervene as if left untreated, central precocious puberty will result in progressive sexual characteristic development, early menstrual onset and rapid skeletal maturation, resulting in early epiphyseal stimulation. Conclusions: Central precocious puberty is an important condition to recognize. It is important to screen when advanced pubertal characteristics are seen under age 7 years. Once idiopathic precocious puberty has been confirmed there are many options for treatment with good long-term outcomes, which allow for attainment of predicted genetic height.

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References

  1. Loomba-Albrecht LA, Styne DA. The physiology of puberty and its disorders. Pediatr Ann. 2012;41(4):e1–9.

    Article  PubMed  Google Scholar 

  2. Sorensen K, Mouritsen A, Aksglaede L, Hagen CP, Mogensen SS, Juul A. Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty. Horm Res Pediatr. 2012;77:137–45.

    Article  CAS  Google Scholar 

  3. Sperling M, editor. Pediatric endocrinology. 3rd ed. Philadelphia: Saunders; 2008. p. 530–609.

    Google Scholar 

  4. Ucar A, Saka N, Bas F, Bundak R, Gunoz H, Darendeliler F. Is premature thelarche in the first two years of life transient? J Clin Res Pediatr Endocrinol. 2012;4(3):140–5.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Lee PA. Central precocious puberty: an overview of diagnosis, treatment and outcome. Endocrinol Metab Clin North Am. 1999;28(4):901–18.

    Article  CAS  PubMed  Google Scholar 

  6. Martin DD, Meister K, Schwiezer R, Ranke MB, Thodberg HH, Binder G. Validation of automatic bone age rating in children with precocious and early puberty. J Pediatr Endocrinol Metab. 2011;24(11–12):1009–14.

    PubMed  Google Scholar 

  7. Houk CP, Kunselman AR, Lee PA. Adequacy of a single unstimulated luteinizing hormone level to diagnose central precocious puberty in girls. Pediatrics. 2009;123:e1059–63.

    Article  PubMed  Google Scholar 

  8. Kilic A, et al. Clinical and laboratory characteristics of children referred for early puberty: preponderance in 7-8 years of age. J Clin Res Pediatr Endocrinol. 2012;4(4):208–12.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Sathavisam A, Rosenberg HK, Shapiro S, Wang H, Rapaport R. Pelvic ultrasonography in the evaluation of central precocious puberty: comparison with leuprolide stimulation test. J Pediatr. 2011;159(3):490–5.

    Article  Google Scholar 

  10. Fritz M, Speroff L, editors. Clinical gynecologic endocrinology and infertility. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 391–434.

    Google Scholar 

  11. Emans SJ, Laufer MR, Goldstein DP, editors. Pediatric and adolescent gynecology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 156–80.

    Google Scholar 

  12. Sanfilippo JS, Muram D, Dewhurst J, Lee PA, editors. Pediatric and adolescent gynecology. 2nd ed. Philadelphia: W.B. Saunders; 2001. p. 59–71.

    Google Scholar 

  13. Chi CH, Durham E, Neely EK. Pharmacodynamics of aqueous leuprolide acetate stimulation testing in girls: correlation between clinical diagnosis and time of peak luteining hormone level. J Pediatr. 2012;161(4):757–9.

    Article  CAS  PubMed  Google Scholar 

  14. Prasad HK, Khadilkar VV, Jahagirdar R, Khadilkar AV, Lalwani SK. Evaluation of GnRH analogue testing in diagnosis and management of children with pubertal disorders. Indian J Endocrinol Metab. 2012;16(3):400–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Sathasivam A, Garibaldi L, Shapiro S, Godbold J, Rapaport R. Leuprolide stimulation testing for the evaluation of early sexual maturation. Clin Endocrinol. 2010;73:375–81.

    Article  CAS  Google Scholar 

  16. Allali S, Lemaire P, Couto-Silva AC, Prete G, Trivin C, Brauner R. Predicting the adult height of girls with central precocious puberty. Med Sci Monit. 2011;17(6):41–8.

    Article  Google Scholar 

  17. Ko JH, Lee HS, Kim SM, Hwang JS. Changes in bone mineral density and body composition in children with central precocious puberty and early puberty before and after one year of treatment with GnRH agonist. Horm Res Paediatr. 2011;75(3):174–9.

    Article  CAS  PubMed  Google Scholar 

  18. Eugster EA, et al. Efficacy of histrelin subdermal implant in children with central precocious puberty: a multicenter trial. J Clin Endocrinol Metab. 2007;92(5):1697–704.

    Article  CAS  PubMed  Google Scholar 

  19. Kim EY, Lee MI. Psychosocial aspects in girls with idiopathic precocious puberty. Psychiatry Investig. 2012;9(1):25–8.

    Article  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics, Gynecology, and Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, 6651 Main St, Suite F1050, Houston, TX, 77030, USA

    Jennifer E. Dietrich M.D., M.Sc.

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  1. Jennifer E. Dietrich M.D., M.Sc.
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Correspondence to Jennifer E. Dietrich M.D., M.Sc. .

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Editors and Affiliations

  1. Department of Obstetrics, Gynecology, and Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, USA

    Jennifer E. Dietrich

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Dietrich, J.E. (2014). Central Precocious Puberty. In: Dietrich, J. (eds) Female Puberty. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0912-4_6

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  • DOI: https://doi.org/10.1007/978-1-4939-0912-4_6

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-0911-7

  • Online ISBN: 978-1-4939-0912-4

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