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Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease pp 177–194Cite as

Microbiome, HPA Axis and Production of Endocrine Hormones in the Gut

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Part of the book series: Advances in Experimental Medicine and Biology ((MICENDO,volume 817))

Abstract

Recent accumulating evidence indicates that the gut microbiome can affect the development and regulation of the hypothalamic-pituitary-adrenal axis and behavior, with central integrative systems being crucial in the successful physiological adaptation of the organism to external stressor. In contrast, host-derived hormones increase the bacterial proliferative capacity and pathogenicity. In the gut lumen, this type of cross-talk between microorganisms and the host is presumed to be performed continually through various kinds of luminal molecules, as numerous types of bacteria and host cells are in close proximity in the gastrointestinal tract of mammals.

We herein focus on bidirectional signaling between the gut microbiome and the host in terms of commensal microbiota affecting the hypothalamic-pituitary-adrenal HPA axis response and behaviors and further discuss the role of gut luminal catecholamines and γ-aminobutyric acid, both of which are presumed to be involved in this signaling.

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Abbreviations

ACTH:

Adrenocorticotropin hormone

CA:

Catecholamines

CRH:

Corticotrophin-releasing hormone

DA:

Dopamine

E:

Epinephrine

EHEC:

Enterohemorrhagic Escherichia coli

GABA:

γ-Aminobutyric acid

GAD:

Glutamic acid decarboxylase

GC:

Glucocorticoids

GUS:

β-Glucuronidase

HPA:

Hypothalamic-pituitary-adrenal

NE:

Norepinephrine

Tir:

Translocated intimin receptor

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Authors and Affiliations

  1. Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Nobuyuki Sudo

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  1. Nobuyuki Sudo
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Correspondence to Nobuyuki Sudo .

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Editors and Affiliations

  1. Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, Texas, USA

    Mark Lyte

  2. Department of Anatomy and Neuroscience, University College, Cork, Cork, Ireland

    John F. Cryan

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Sudo, N. (2014). Microbiome, HPA Axis and Production of Endocrine Hormones in the Gut. In: Lyte, M., Cryan, J. (eds) Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease. Advances in Experimental Medicine and Biology(), vol 817. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0897-4_8

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