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Applications of Molecular Small-Animal Imaging in Cardiology

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Molecular Imaging of Small Animals

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Abstract

Cardiovascular disease (CVD) is a leading cause of death in both industrialized and developing countries, claiming more than 800,000 lives in the US and millions more in the rest of the world in recent years. Despite recent reduction in age-specific CVD mortality rate, increasing longevity, urbanization and industrialization has led to a rapid increase in the prevalence of CVD in both developed and developing nations. With surging health care costs the focus is shifting from treatment to prevention of disease as well as developing cost effective diagnostic and prognostic strategies. Conventional imaging modalities such as coronary angiography, echocardiography, myocardial perfusion imaging, computed tomography (CT) and magnetic resonance imaging (MRI), have been historically used to define structure and function as well as to monitor response to therapy, relying on the contrast provided by heterogeneity of anatomy, physiology and metabolism. As such, they provide valuable anatomical and physiological information about vasculature (e.g., extent of the disease, location, presence of calcification) and the myocardium (e.g., ejection fraction, wall thickening, dilatation, viability and cardiac output). However, traditional imaging modalities have limited use in detecting molecular and cellular events that determine the course of disease and its response to therapeutic interventions. Emerging molecular imaging modalities utilizing probes targeted at relevant molecular and cellular events can advance research on pathophysiology, allow early detection of disease, assist in the design of novel therapies, facilitate monitoring disease activity and response to therapy, and provide prognostic information.

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Acknowledgments

This work was supported by National Institutes of Health R01 HL85093, and a Department of Veterans Affairs Merit Award to MMS.

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  1. Cardiovascular Molecular Imaging Laboratory, Yale University School of Medicine, New Haven, CT, 06520-8017, USA

    Ravi Marfatia, Sina Tavakoli & Mehran M. Sadeghi

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  1. Ravi Marfatia
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  2. Sina Tavakoli
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  3. Mehran M. Sadeghi
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Correspondence to Mehran M. Sadeghi .

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  1. Department of Radiology & Medical Informatics, Geneva University Hospital, Geneva, Switzerland

    Habib Zaidi

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Marfatia, R., Tavakoli, S., Sadeghi, M.M. (2014). Applications of Molecular Small-Animal Imaging in Cardiology. In: Zaidi, H. (eds) Molecular Imaging of Small Animals. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0894-3_20

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