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Quantification of Small-Animal Imaging Data

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Molecular Imaging of Small Animals

Abstract

The field of molecular imaging finds its roots in nuclear medicine, which since its inception had a major focus on task-based optimization of image quality, and on in vivo quantitative assessment of metabolic and physiological parameters [1]. This standpoint reflects the limited spatial resolution and high noise characteristics of SPECT and PET compared to high resolution structural imaging modalities (CT and MRI), which provide exquisite anatomical details. The disparities between performance characteristics of currently available scanners and their potential degradation with time can be delicate and tricky to put into evidence through qualitative visual interpretation. This has motivated the development of objective and reproducible metrics to observe and adjust changes in system performance, for intercomparison studies as well as for quality assurance and quality control tasks. The use of molecular imaging in the assessment of metabolic and physiological parameters linked to specific diseases further motivated quantitative molecular imaging.

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Acknowledgments

This work was supported by the Swiss National Science Foundation under grant SNSF 31003A-125246. The author would like to thank Rameshwar Prasad (PhD student) for supplying some of the material used in this chapter.

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    Habib Zaidi

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    Habib Zaidi

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Zaidi, H. (2014). Quantification of Small-Animal Imaging Data. In: Zaidi, H. (eds) Molecular Imaging of Small Animals. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0894-3_17

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