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Human T-Cell Leukemia Virus Type 1: Epidemiology and Clinical Features of Related Cancer

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Viruses and Human Cancer

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Abstract

The first key event in the establishment of human retrovirus, known as human T-cell leukemia virus type 1 (HTLV-1) was the discovery of adult T-cell leukemia/lymphoma (ATLL) by Takatsuki and his colleagues in 1977. The leukemia cells in patients were characterized by unusual morphology with ovulated nuclei, which were named “flower-like cells.” These abnormal cells were soon identified as T cells expressing interleukin 2-receptor (IL-2R/CD 25) at abnormally high levels. While infection with HTLV-1 is a direct cause of ATLL, it can indirectly cause many other diseases via the induction of immunodeficiency and/or immune reaction, such as chronic lung disease, opportunistic lung infections, chronic renal failure, nonspecific dermatomycosis, nonspecific arthritis, HTLV-1-associated lymphadenitis, HTLV-1 uveitis, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

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  1. Department of Pathology, School of Medicine, Kurume University, Asahimati 67, Kurume, Fukuoka, 830-0011, Japan

    Koichi Ohshima M.D., Ph.D.

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  1. Pathology and Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

    S. David Hudnall

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Ohshima, K. (2014). Human T-Cell Leukemia Virus Type 1: Epidemiology and Clinical Features of Related Cancer. In: Hudnall, S. (eds) Viruses and Human Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0870-7_11

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