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Multicentric Castleman Disease

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Cancers in People with HIV and AIDS

Abstract

Multicentric Castleman disease is a systemic disorder of lymph nodes characterized by inflammatory symptoms including fever, night sweats, cachexia, malaise, and lymphadenopathy together with laboratory abnormalities including anemia and hypoalbuminemia. These symptoms may be life-threatening. The diagnosis is based on specific pathological findings in affected lymph nodes. In individuals infected with HIV, multicentric Castleman disease is almost exclusively caused by infection with a cancer-causing herpesvirus, Kaposi sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8). This may be considered a separate entity from the non-KSHV related or idiopathic form of multicentric Castleman disease and from unicentric forms of Castleman disease. While these disorders have pathological and clinical similarities, the KSHV-related form is distinguished by its pathological characteristics and unique viral etiology.

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Acknowledgment

This work was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute.

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Authors and Affiliations

  1. HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Mark N. Polizzotto & Thomas S. Uldrick

  2. HIV and AIDS Malignancy Branch and office of HIV and AIDS Malignancy, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Robert Yarchoan

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  1. Mark N. Polizzotto
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Correspondence to Mark N. Polizzotto .

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  1. National Cancer Institute HIV/AIDS Malignancy Branch, National Institutes of Health, Bethesda, Maryland, USA

    Robert Yarchoan

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Polizzotto, M.N., Uldrick, T.S., Yarchoan, R. (2014). Multicentric Castleman Disease. In: Yarchoan, R. (eds) Cancers in People with HIV and AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0859-2_18

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